Gene-expression profiling discriminates between cerebral malaria (CM) - susceptible mice and CM-resistant mice

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cg.identifier.doihttps://doi.org/10.1086/498579en
cg.issn0022-1910en
cg.issue2en
cg.journalJournal of Infectious Diseasesen
cg.subject.ilriVACCINESen
cg.subject.ilriGENETICSen
cg.subject.ilriDISEASE CONTROLen
cg.volume193en
dc.contributor.authorDelhaye, N.F.en
dc.contributor.authorColtel, N.en
dc.contributor.authorPuthier, D.en
dc.contributor.authorFlori, L.en
dc.contributor.authorHoulgatte, R.en
dc.contributor.authorIraqi, F.A.en
dc.contributor.authorNguyen, C.en
dc.contributor.authorGrau, G.E.en
dc.contributor.authorRihet, P.en
dc.date.accessioned2013-06-11T09:24:20Zen
dc.date.available2013-06-11T09:24:20Zen
dc.identifier.urihttps://hdl.handle.net/10568/29649
dc.titleGene-expression profiling discriminates between cerebral malaria (CM) - susceptible mice and CM-resistant miceen
dcterms.abstractThe development of cerebral malaria (CM) in mice with Plasmodium berghei ANKA infection is under genetic control. Brain gene-expression patterns were investigated in well-defined genetically CM-resistant (CM-R; BALB/c and DBA/2) and CM-susceptible (CM-S; C57BL/6 and CBA/J) mice by use of cDNA microarrays. By combining transcriptional profiling with rigorous statistical methods and cluster analysis, we identified a set of 69 genes that perfectly discriminated between mouse strains and between CM-R and CM-S mice. The analysis of gene ontological terms revealed that the genes that clustered and were related to susceptibility to CM preferentially belonged to some biological process classes, such as those pertaining to immune responses. Using a false discovery rate of 5% and the Welch t test, we identified 31 genes with consistent differential expression between CM-R and CM-S mice. These data indicate that microarray analysis may be useful for identification of candidate genes that are potentially responsible for resistance or susceptibility to mouse CM and suggest that candidate genes identified in mice could be specifically tested in humans for an association with disease severity.en
dcterms.accessRightsLimited Accessen
dcterms.bibliographicCitationThe Journal of Infectious Diseases;193(2): 312-321en
dcterms.extentp. 312-321en
dcterms.issued2006-01-15en
dcterms.languageenen
dcterms.publisherOxford University Pressen
dcterms.subjectmalariaen
dcterms.subjectgene expressionen
dcterms.subjectbrainen
dcterms.subjectmiceen
dcterms.subjectdisease resistanceen
dcterms.subjectimmunityen
dcterms.subjectplasmodium bergheien
dcterms.subjectgenetic controlen
dcterms.subjectdnaen
dcterms.typeJournal Articleen

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