The genome of Caenorhabditis bovis

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationUniversity of Edinburghen
cg.contributor.affiliationUniversity of Liverpoolen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationKenya Medical Research Instituteen
cg.contributor.affiliationBusia County Government, Kenyaen
cg.contributor.affiliationBungoma County Government, Kenyaen
cg.contributor.crpAgriculture for Nutrition and Healthen
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen
cg.contributor.donorEconomic and Social Research Council, United Kingdomen
cg.contributor.donorMedical Research Council, United Kingdomen
cg.contributor.donorNatural Environment Research Council, United Kingdomen
cg.contributor.donorDefence Science and Technology Laboratory, United Kingdomen
cg.coverage.countryKenyaen
cg.coverage.iso3166-alpha2KEen
cg.coverage.regionAfricaen
cg.coverage.regionEastern Africaen
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986en
cg.creator.identifierMaurice Murungi: 0000-0001-6467-4352en
cg.creator.identifierLaura Cristina Falzon: 0000-0002-4043-1644en
cg.creator.identifierEunice Machuka: 0000-0002-1142-3442en
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1016/j.cub.2020.01.074en
cg.isijournalISI Journalen
cg.issn0960-9822en
cg.issue6en
cg.journalCurrent Biologyen
cg.reviewStatusPeer Reviewen
cg.subject.ilriANIMAL DISEASESen
cg.subject.ilriCATTLEen
cg.subject.ilriGENETICSen
cg.subject.ilriLIVESTOCKen
cg.subject.ilriZOONOTIC DISEASESen
cg.volume30en
dc.contributor.authorStevens, L.en
dc.contributor.authorRooke, S.en
dc.contributor.authorFalzon, Laura C.en
dc.contributor.authorMachuka, Eunice M.en
dc.contributor.authorMomanyi, Kelvin N.en
dc.contributor.authorMurungi, Maurice K.en
dc.contributor.authorNjoroge, Samuel M.en
dc.contributor.authorOdinga, Christian O.en
dc.contributor.authorOgendo, A.en
dc.contributor.authorOgola, J.en
dc.contributor.authorFèvre, Eric M.en
dc.contributor.authorBlaxter, M.en
dc.date.accessioned2020-03-04T08:16:41Zen
dc.date.available2020-03-04T08:16:41Zen
dc.identifier.urihttps://hdl.handle.net/10568/107367
dc.titleThe genome of Caenorhabditis bovisen
dcterms.abstractThe free-living nematode Caenorhabditis elegans is a key laboratory model for metazoan biology. C. elegans has also become a model for parasitic nematodes despite being only distantly related to most parasitic species. All of the ∼65 Caenorhabditis species currently in culture are free-living, with most having been isolated from decaying plant or fungal matter. Caenorhabditis bovis is a particularly unusual species that has been isolated several times from the inflamed ears of Zebu cattle in Eastern Africa, where it is associated with the disease bovine parasitic otitis. C. bovis is therefore of particular interest to researchers interested in the evolution of nematode parasitism. However, as C. bovis is not in laboratory culture, it remains little studied. Here, by sampling livestock markets and slaughterhouses in Western Kenya, we successfully reisolated C. bovis from the ear of adult female Zebu. We sequenced the genome of C. bovis using the Oxford Nanopore MinION platform in a nearby field laboratory and used the data to generate a chromosome-scale draft genome sequence. We exploited this draft genome sequence to reconstruct the phylogenetic relationships of C. bovis to other Caenorhabditis species and reveal the changes in genome size and content that have occurred during its evolution. We also identified expansions in several gene families that have been implicated in parasitism in other nematode species. The high-quality draft genome and our analyses thereof represent a significant advancement in our understanding of this unusual Caenorhabditis species.en
dcterms.accessRightsOpen Accessen
dcterms.audienceScientistsen
dcterms.bibliographicCitationStevens, L., Rooke, S., Falzon, L.C., Machuka, E.M., Momanyi, K., Murungi, M.K., Njoroge, S.M., Odinga, C.O., Ogendo, A., Ogola, J., Fèvre, E.M. and Blaxter, M. 2020. The genome of Caenorhabditis bovis. Current Biology 30(6): 1023–1031.en
dcterms.extentp. 1023-1031.e4en
dcterms.issued2020-03en
dcterms.languageenen
dcterms.licenseCC-BY-4.0en
dcterms.publisherElsevieren
dcterms.subjectgenomicsen
dcterms.subjectnematodesen
dcterms.subjectlivestocken
dcterms.subjectcattleen
dcterms.subjectzoonosesen
dcterms.subjectanimal diseasesen
dcterms.typeJournal Articleen

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