Inherited tolerance in cattle to the apicomplexan protozoan Theileria parva is associated with decreased proliferation of parasite-infected lymphocytes

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationUniversity of Edinburghen
cg.contributor.affiliationOl Pejeta Conservancy, Kenyaen
cg.contributor.crpLivestock
cg.contributor.donorBill & Melinda Gates Foundationen
cg.contributor.donorForeign, Commonwealth and Development Office, United Kingdomen
cg.creator.identifierElizabeth Cook: 0000-0001-6081-8363en
cg.creator.identifierElizabeth Jane Poole: 0000-0002-8570-794Xen
cg.creator.identifierPhilip Toye: 0000-0002-7100-2789en
cg.creator.identifierAntoinette Aluoch: 0000-0001-7197-7837en
cg.creator.identifierMaurine Chepkwony Makau: 0000-0002-7684-6171en
cg.creator.identifierTatjana Sitt: 0000-0001-7104-2345en
cg.creator.identifierJames Prendergast: 0000-0001-8916-018Xen
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.3389/fcimb.2021.751671en
cg.isijournalISI Journalen
cg.issn2235-2988en
cg.journalFrontiers in Cellular and Infection Microbiologyen
cg.placeNairobi, Kenyaen
cg.reviewStatusPeer Reviewen
cg.subject.ilriANIMAL DISEASESen
cg.subject.ilriCATTLEen
cg.subject.ilriDISEASE CONTROLen
cg.subject.ilriECFen
cg.subject.ilriLIVESTOCKen
cg.volume11en
dc.contributor.authorLatré de Laté, Perleen
dc.contributor.authorCook, Elizabeth A.J.en
dc.contributor.authorWragg, Daviden
dc.contributor.authorPoole, Elizabeth J.en
dc.contributor.authorNdambuki, Gideon M.en
dc.contributor.authorMiyunga, Antoinetteen
dc.contributor.authorChepkwony, Maurine C.en
dc.contributor.authorMwaura, Stephenen
dc.contributor.authorNdiwa, Nicholas N.en
dc.contributor.authorPrettejohn, Gilesen
dc.contributor.authorSitt, Tatjanaen
dc.contributor.authorAardt, Richard vanen
dc.contributor.authorMorrison, W. Ivanen
dc.contributor.authorPrendergast, James G.D.en
dc.contributor.authorToye, Philip G.en
dc.date.accessioned2021-11-17T17:02:30Zen
dc.date.available2021-11-17T17:02:30Zen
dc.identifier.urihttps://hdl.handle.net/10568/116125
dc.titleInherited tolerance in cattle to the apicomplexan protozoan Theileria parva is associated with decreased proliferation of parasite-infected lymphocytesen
dcterms.abstractTheileria parva is the causative agent of East Coast fever and Corridor disease, which are fatal, economically important diseases of cattle in eastern, central and southern Africa. Improved methods of control of the diseases are urgently required. The parasite transforms host lymphocytes, resulting in a rapid, clonal expansion of infected cells. Resistance to the disease has long been reported in cattle from T. parva-endemic areas. We reveal here that first- and second-generation descendants of a single Bos indicus bull survived severe challenge with T. parva, (overall survival rate 57.3% compared to 8.7% for unrelated animals) in a series of five field studies. Tolerant cattle displayed a delayed and less severe parasitosis and febrile response than unrelated animals. The in vitro proliferation of cells from surviving cattle was much reduced compared to those from animals that succumbed to infection. Additionally, some pro-inflammatory cytokines such as IL1β, IL6, TNFα or TGFβ which are usually strongly expressed in susceptible animals and are known to regulate cell growth or motility, remain low in tolerant animals. This correlates with the reduced proliferation and less severe clinical reactions observed in tolerant cattle. The results show for the first time that the inherited tolerance to T. parva is associated with decreased proliferation of infected lymphocytes. The results are discussed in terms of whether the reduced proliferation is the result of a perturbation of the transformation mechanism induced in infected cells or is due to an innate immune response present in the tolerant cattle.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.available2021-11-05en
dcterms.bibliographicCitationLatre de Late, P., Cook, E.A.J., Wragg, D., Poole, E.J., Ndambuki, G., Miyunga, A.A., Chepkwony, M.C., Mwaura, S., Ndiwa, N., Prettejohn, G., Sitt, T., Van Aardt, R., Morrison, W.I., Prendergast, J. and Toye, P. 2021. Inherited tolerance in cattle to the apicomplexan protozoan Theileria parva is associated with decreased proliferation of parasite-infected lymphocytes. Frontiers in Cellular and Infection Microbiology 11:751671.en
dcterms.issued2021-11-05en
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherFrontiers Mediaen
dcterms.subjectanimal diseasesen
dcterms.subjectdisease controlen
dcterms.subjecteast coast feveren
dcterms.subjecttheileria parvaen
dcterms.subjectcattleen
dcterms.typeJournal Article

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