Anthropogenic events and responses to environmental stress are shaping the genomes of Ethiopian indigenous goats

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationTigray Agricultural Research Institute, Ethiopiaen_US
cg.contributor.affiliationAddis Ababa Universityen_US
cg.contributor.affiliationScotland's Rural Collegeen_US
cg.contributor.affiliationMisurata Universityen_US
cg.contributor.affiliationJackson Laboratoryen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationChinese Academy of Agricultural Sciencesen_US
cg.contributor.affiliationUniversity of Liverpoolen_US
cg.contributor.affiliationWashington Universityen_US
cg.contributor.affiliationUniversity of Sydneyen_US
cg.contributor.affiliationUniversity of Oxforden_US
cg.contributor.affiliationUniversity of Nottinghamen_US
cg.contributor.affiliationInternational Centre for Agricultural Research in the Dry Areasen_US
cg.contributor.donorUK Research and Innovationen_US
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen_US
cg.contributor.initiativeSustainable Animal Productivityen_US
cg.coverage.countryEthiopiaen_US
cg.coverage.iso3166-alpha2ETen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierTadelle Dessie: 0000-0002-1630-0417en_US
cg.creator.identifierOlivier Hanotte: 0000-0002-2877-4767en_US
cg.creator.identifierSiobhan Mor: 0000-0003-0121-2016en_US
cg.creator.identifierJoram Mwacharo: 0000-0001-6981-8140en_US
cg.creator.identifierGetinet Mekuriaw Tarekegn: 0000-0001-7221-2473en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1038/s41598-024-65303-xen_US
cg.isijournalISI Journalen_US
cg.issn2045-2322en_US
cg.issue1en_US
cg.journalScientific Reportsen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.actionAreaResilient Agrifood Systemsen_US
cg.subject.ilriANIMAL BREEDINGen_US
cg.subject.ilriGENETICSen_US
cg.subject.ilriGOATSen_US
cg.subject.ilriINDIGENOUS BREEDSen_US
cg.subject.impactAreaClimate adaptation and mitigationen_US
cg.subject.impactAreaEnvironmental health and biodiversityen_US
cg.subject.sdgSDG 1 - No povertyen_US
cg.subject.sdgSDG 13 - Climate actionen_US
cg.volume14en_US
dc.contributor.authorBelay, Shumuyeen_US
dc.contributor.authorBelay, Gurjaen_US
dc.contributor.authorNigussie, Helenen_US
dc.contributor.authorAhbara, Abulgasimen_US
dc.contributor.authorTijjani, Abdulfataien_US
dc.contributor.authorDessie, Tadelleen_US
dc.contributor.authorMekuriaw, Getineten_US
dc.contributor.authorHan, Jian-Linen_US
dc.contributor.authorMor, Siobhan M.en_US
dc.contributor.authorWoldekiros, H.S.en_US
dc.contributor.authorDobney, Kiethen_US
dc.contributor.authorLebrasseur, Ophelieen_US
dc.contributor.authorHanotte, Olivier H.en_US
dc.contributor.authorMwacharo, Joram M.en_US
dc.date.accessioned2024-07-14T16:03:55Zen_US
dc.date.available2024-07-14T16:03:55Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/149069en_US
dc.titleAnthropogenic events and responses to environmental stress are shaping the genomes of Ethiopian indigenous goatsen_US
dcterms.abstractAnthropological and biophysical processes have shaped livestock genomes over Millenia and can explain their current geographic distribution and genetic divergence. We analyzed 57 Ethiopian indigenous domestic goat genomes alongside 67 equivalents of east, west, and north-west African, European, South Asian, Middle East, and wild Bezoar goats. Cluster, ADMIXTURE (K = 4) and phylogenetic analysis revealed four genetic groups comprising African, European, South Asian, and wild Bezoar goats. The Middle Eastern goats had an admixed genome of these four genetic groups. At K = 5, the West African Dwarf and Moroccan goats were separated from East African goats demonstrating a likely historical legacy of goat arrival and dispersal into Africa via the coastal Mediterranean Sea and the Horn of Africa. FST, XP-EHH, and Hp analysis revealed signatures of selection in Ethiopian goats overlaying genes for thermo-sensitivity, oxidative stress response, high-altitude hypoxic adaptation, reproductive fitness, pathogen defence, immunity, pigmentation, DNA repair, modulation of renal function and integrated fluid and electrolyte homeostasis. Notable examples include TRPV1 (a nociception gene); PTPMT1 (a critical hypoxia survival gene); RETREG (a regulator of reticulophagy during starvation), and WNK4 (a molecular switch for osmoregulation). These results suggest that human-mediated translocations and adaptation to contrasting environments are shaping indigenous African goat genomes.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceScientistsen_US
dcterms.available2024-06-28en_US
dcterms.bibliographicCitationBelay, S., Belay, G., Nigussie, H., Ahbara, A.M., Tijjani, A., Dessie, T., Mekuriaw, G., Han Jian‑Lin, Mor, S., Woldekiros, H.S., Dobney, K., Lebrasseur, O., Hanotte, O. and Mwacharo, J.M. 2024. Anthropogenic events and responses to environmental stress are shaping the genomes of Ethiopian indigenous goats. Scientific Reports 14:14908.en_US
dcterms.issued2024-06-28en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherNature Portfolioen_US
dcterms.replaceshttps://hdl.handle.net/10568/169108en_US
dcterms.subjectanimal breedingen_US
dcterms.subjectgeneticsen_US
dcterms.subjectlandracesen_US
dcterms.subjectgoatsen_US
dcterms.subjectgenomesen_US
dcterms.typeJournal Articleen_US

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