Seroprevalence and risk factors of peste des petits ruminants in different production systems in Uganda

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationFreie Universität Berlinen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationMinistry of Agriculture, Animal Industry and Fisheries, Ugandaen_US
cg.contributor.affiliationMakerere Universityen_US
cg.contributor.affiliationFederal Center for Animal Health, Russiaen_US
cg.contributor.affiliationInstitute of Virology and Immunology, Switzerlanden_US
cg.contributor.affiliationUniversity of Bernen_US
cg.contributor.affiliationUniversity of Minnesotaen_US
cg.contributor.donorFederal Ministry for Economic Cooperation and Development, Germanyen_US
cg.coverage.countryUgandaen_US
cg.coverage.iso3166-alpha2UGen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierJoseph Nkamwesiga: 0000-0001-6524-1241en_US
cg.creator.identifierKristina Roesel: 0000-0002-2553-1129en_US
cg.creator.identifierHenry Kiara: 0000-0001-9578-1636en_US
cg.creator.identifierBarbara Wieland: 0000-0003-4020-9186en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1016/j.prevetmed.2023.106051en_US
cg.isijournalISI Journalen_US
cg.issn0167-5877en_US
cg.journalPreventive Veterinary Medicineen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.actionAreaResilient Agrifood Systemsen_US
cg.subject.ilriANIMAL DISEASESen_US
cg.subject.ilriGOATSen_US
cg.subject.ilriPPRen_US
cg.subject.ilriSHEEPen_US
cg.subject.ilriSMALL RUMINANTSen_US
cg.subject.impactAreaNutrition, health and food securityen_US
cg.subject.impactPlatformNutrition, Health and Food Securityen_US
cg.subject.sdgSDG 2 - Zero hungeren_US
cg.volume221en_US
dc.contributor.authorNkamwesiga, Josephen_US
dc.contributor.authorLumu, P.en_US
dc.contributor.authorNalumenya, D.P.en_US
dc.contributor.authorKorennoy, F.en_US
dc.contributor.authorRoesel, Kristinaen_US
dc.contributor.authorWieland, Barbaraen_US
dc.contributor.authorPérez, A.en_US
dc.contributor.authorKiara, Henry K.en_US
dc.contributor.authorMuhanguzi, D.en_US
dc.date.accessioned2023-10-20T13:54:45Zen_US
dc.date.available2023-10-20T13:54:45Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/132350en_US
dc.titleSeroprevalence and risk factors of peste des petits ruminants in different production systems in Ugandaen_US
dcterms.abstractPeste des petits ruminants (PPR) is a highly contagious and fatal disease of mostly domestic goats and sheep. First reported in Uganda in 2007, the extent of peste des petits ruminants virus (PPRV) exposure, geographical distribution and risk factors of its transmission and spread are not clearly understood. In this study, we used cluster random sampling methodology to select study villages from three districts representing three different production systems along Uganda’s “cattle corridor”. Between October and December 2022, 2,520 goat and sheep serum samples were collected from 252 households with no history of PPR vaccination in the past one year. The household heads were interviewed to assess possible risk factors of PPRV transmission using a structured questionnaire. The serum samples were screened with a commercial competitive enzyme-linked immunosorbent assay (cELISA) for PPRV antibodies. The determined overall true seroprevalence of PPRV was 27.3% [95% CI: 25.4–29.1]. The seroprevalence of PPRV antibodies in different production systems was 44.1% [95% CI: 40.6–47.7], 31.7% [95% CI: 28.4–35.0] and 6.1% [95% CI: 4.4–7.9] for pastoral, agropastoral and mixed crop-livestock production systems respectively. A mixed-effects multivariable logistic regression model revealed strong statistical evidence of association between female animals and PPRV antibody seropositivity compared to males [OR=2.45, 95% CI: 1.7–3.5, p < 0.001]. The likelihood of being PPRV antibody seropositive significantly increased with increasing small ruminant age. Animals older than 3 years were more than three times as likely to be PPRV seropositive compared to animals aged under 1 year [OR= 3.41, 95% CI: 2.39–4.85, p < 0.001]. There was no statistical evidence of association between small ruminant species and PPRV antibody seropositivity (p = 0.423). Village flocks that interacted with neighboring flocks daily during grazing (IRR = 1.59, 95% CI: 1.19–2.13) and watering around swamps (IRR = 1.59, 95% CI: 1.19–2.13) were highly correlated with increased number of PPRV seropositive animals as compared to flocks that were more restricted in grazing and watered around other water sources other than swamps. Flocks from pastoral and agropastoral production systems were more than 10 times more likely to have seropositive animals than mixed crop-livestock flocks. Targeting PPR control interventions (vaccination and livestock movement control) to pastoral and agro-pastoral small ruminant production systems that are very prone to PPR incursions is recommended to prevent PPRV spread to low-risk smallholder mixed crop-livestock production systems.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceAcademicsen_US
dcterms.audienceScientistsen_US
dcterms.available2023-10-18en_US
dcterms.bibliographicCitationNkamwesiga, J., Lumu, P., Nalumenya, D.P., Korennoy, F., Roesel, K., Wieland, B., Perez, A., Kiara, H. and Muhanguzi, D. 2023. Seroprevalence and risk factors of peste des petits ruminants in different production systems in Uganda. Preventive Veterinary Medicine 221: 106051.en_US
dcterms.extent106051en_US
dcterms.issued2023-12en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherElsevieren_US
dcterms.subjectanimal diseasesen_US
dcterms.subjectpest of small ruminantsen_US
dcterms.subjectsmall ruminantsen_US
dcterms.subjectsheepen_US
dcterms.subjectgoatsen_US
dcterms.typeJournal Articleen_US

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