Cytokine mRNA profiles in bovine macrophages stimulated with Trypanosoma congolense

Simple item page
cg.creator.identifierJan Naessens: 0000-0002-7075-9915
cg.identifier.urlhttp://www.jstage.jst.go.jp/article/jvms/69/4/421/_pdfen
cg.issn0916-7250en
cg.journalJournal of Veterinary Medical Scienceen
cg.subject.ilriDISEASE CONTROLen
cg.subject.ilriANIMAL DISEASESen
cg.subject.ilriLIVESTOCKen
dc.contributor.authorKazuhiro, Y.en
dc.contributor.authorAgaba, Morrisen
dc.contributor.authorIraqi, F.A.en
dc.contributor.authorNaessens, Janen
dc.date.accessioned2010-05-18T20:14:33Zen
dc.date.available2010-05-18T20:14:33Zen
dc.identifier.urihttps://hdl.handle.net/10568/1543
dc.titleCytokine mRNA profiles in bovine macrophages stimulated with Trypanosoma congolenseen
dcterms.abstractIt is known that different breeds of cattle display differential susceptibilities to Trypanosome congolense infections, and that N'Dama cattle remain more productive after infection than Boran cattle which are more susceptible to T. congolense. Macrophages from both breeds were cultured in vitro and the expressions of a number of cytokines and iNOS mRNA were analyzed using real time RT-PCR after stimulation with antibody-opsonized trypanosomes. No significant difference was seen between the responses of the two breeds. However, RNA levels of TNF-α in the IFN-γ-primed macrophages were about 100-fold higher than those in the non-primed macrophages. A significant ten-fold decrease was seen for the anti-inflammatory cytokine IL-10. These results indicate that priming of the cells with IFN-y cause a serious shift toward an inflammatory response.en
dcterms.accessRightsOpen Access
dcterms.bibliographicCitationYoshihara, K.; Agaba, M.; Iraqi, F.; Naessens, J. 2007. Cytokine mRNA profiles in bovine macrophages stimulated with Trypanosoma congolense. Journal of the Veterinary Medical Science (Japan) 69:421-423.en
dcterms.extentp. 421-423en
dcterms.issued2007
dcterms.languageen
dcterms.subjecttrypanosomiasisen
dcterms.subjectcattleen
dcterms.typeJournal Article

Files

License bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.73 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ILRI articles in journals
ILRI animal bioscience program outputs
ILRI livestock genetics program outputs