The potential for use of haematological and anti-IgE humoral responses as phenotypic markers for tick resistance in cattle

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationKenyatta Universityen
cg.contributor.affiliationEgerton Universityen
cg.contributor.affiliationUniversity of Edinburghen
cg.contributor.affiliationRothamsted Researchen
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen
cg.contributor.donorNational Research Fund, Kenyaen
cg.contributor.donorCGIAR Trust Funden
cg.coverage.countryKenya
cg.coverage.iso3166-alpha2KE
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifiercollins ngetich: 0000-0001-7269-613X
cg.creator.identifierAppolinaire Djikeng: 0000-0001-9271-3419
cg.creator.identifierNaftaly Githaka: 0000-0003-4530-7164
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1016/j.crpvbd.2023.100159en
cg.isijournalISI Journalen
cg.issn2667-114Xen
cg.journalCurrent Research in Parasitology & Vector-Borne Diseasesen
cg.reviewStatusPeer Reviewen
cg.subject.actionAreaResilient Agrifood Systems
cg.subject.ilriCATTLEen
cg.subject.ilriDISEASE CONTROLen
cg.subject.impactAreaNutrition, health and food security
cg.subject.impactPlatformNutrition, Health and Food Security
cg.subject.sdgSDG 2 - Zero hungeren
cg.volume5en
dc.contributor.authorNgetich, Collinsen
dc.contributor.authorKamau, L.en
dc.contributor.authorSimbauni, J.en
dc.contributor.authorMwendia, C.en
dc.contributor.authorOwido, Miltonen
dc.contributor.authorKioo, I.en
dc.contributor.authorMatika, O.en
dc.contributor.authorFoster, S.en
dc.contributor.authorBirkett, M.en
dc.contributor.authorDjikeng, Appolinaireen
dc.contributor.authorWatson, K.A.en
dc.contributor.authorGithaka, Naftaly W.en
dc.date.accessioned2023-12-05T13:11:33Zen
dc.date.available2023-12-05T13:11:33Zen
dc.identifier.urihttps://hdl.handle.net/10568/135031
dc.titleThe potential for use of haematological and anti-IgE humoral responses as phenotypic markers for tick resistance in cattleen
dcterms.abstractApproximately 80% of the global cattle population is at risk of infestation and infection by ticks and tick-borne diseases (TTBDs). The economic losses from animal mortality, reduced production, vector control costs and animal treatment are very substantial, hence there is an urgent need to develop and deploy alternative vector control strategies. Breeding for host tick resistance has the potential for sustainable large-scale TTBD control especially in cattle. The gold standard method for phenotyping tick resistance in cattle is by counting ticks on the body but is very laborious and subjective. Better methods for phenotyping tick resistance more objectively, faster and at scale, are essential for selecting host genetic resistance to ticks. This study investigated the correlation between haematological cellular profiles and immunological responses (immunoglobulin E, IgE) and full body tick counts in herds of <i>Bos indicus</i> and <i>Bos taurus</i> following artificial tick challenge with <i>Rhipicephalus decoloratus</i> larvae. Fifty-four Friesian and Ayrshire (<i>Bos taurus</i>) and 52 East African Zebu (<i>Bos indicus</i>) calves were each infested with ∼2500 larvae. Near-replete adult female ticks (≥4.5 mm) were counted daily from day 20–25. Blood and serum samples were obtained from each animal on days 0 and 23 for cellular blood and IgE titre analysis, respectively. The indicine cattle were refractory to <i>R. decoloratus</i> infestation in comparison with the taurine breed (<i>P </i>< 0.0001). Repeated measurements of blood components pre-infestation revealed a significant (<i>P </i>< 0.05) association with tick count in IgE and red blood cells, heamatocrit, and haemoglobin post-infestation. There was also a strong positive correlation between the tick counts and red blood cell numbers, haemoglobin, haematocrit, and IgE concentration (<i>P</i> < 0.0001) following tick challenge. The application of this approach to phenotype host resistance needs to be assessed using higher cattle numbers and with different tick species or genera.en
dcterms.accessRightsOpen Access
dcterms.audienceAcademicsen
dcterms.audienceScientistsen
dcterms.available2023-12-15
dcterms.bibliographicCitationNgetich, C., Kamau, L., Simbauni, J., Mwendia, C., Owido, M., Kioo, I., Matika, O., Foster, S., Birkett, M., Djikeng, A., Watson, K.A. and Githaka, N. 2024. The potential for use of haematological and anti-IgE humoral responses as phenotypic markers for tick resistance in cattle. Current <i>Research in Parasitology & Vector-Borne Diseases</i> 5: 100159.en
dcterms.extent100159en
dcterms.issued2024-01
dcterms.languageen
dcterms.licenseCC-BY-NC-ND-4.0
dcterms.publisherElsevieren
dcterms.subjecttick-borne diseasesen
dcterms.subjectcattleen
dcterms.subjectdisease controlen
dcterms.typeJournal Article

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