The potential for use of haematological and anti-IgE humoral responses as phenotypic markers for tick resistance in cattle

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationKenyatta Universityen_US
cg.contributor.affiliationEgerton Universityen_US
cg.contributor.affiliationUniversity of Edinburghen_US
cg.contributor.affiliationRothamsted Researchen_US
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen_US
cg.contributor.donorNational Research Fund, Kenyaen_US
cg.contributor.donorCGIAR Trust Funden_US
cg.coverage.countryKenyaen_US
cg.coverage.iso3166-alpha2KEen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifiercollins ngetich: 0000-0001-7269-613Xen_US
cg.creator.identifierAppolinaire Djikeng: 0000-0001-9271-3419en_US
cg.creator.identifierNaftaly Githaka: 0000-0003-4530-7164en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1016/j.crpvbd.2023.100159en_US
cg.isijournalISI Journalen_US
cg.issn2667-114Xen_US
cg.journalCurrent Research in Parasitology & Vector-Borne Diseasesen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.actionAreaResilient Agrifood Systemsen_US
cg.subject.ilriCATTLEen_US
cg.subject.ilriDISEASE CONTROLen_US
cg.subject.impactAreaNutrition, health and food securityen_US
cg.subject.impactPlatformNutrition, Health and Food Securityen_US
cg.subject.sdgSDG 2 - Zero hungeren_US
cg.volume5en_US
dc.contributor.authorNgetich, Collinsen_US
dc.contributor.authorKamau, L.en_US
dc.contributor.authorSimbauni, J.en_US
dc.contributor.authorMwendia, C.en_US
dc.contributor.authorOwido, Miltonen_US
dc.contributor.authorKioo, I.en_US
dc.contributor.authorMatika, O.en_US
dc.contributor.authorFoster, S.en_US
dc.contributor.authorBirkett, M.en_US
dc.contributor.authorDjikeng, Appolinaireen_US
dc.contributor.authorWatson, K.A.en_US
dc.contributor.authorGithaka, Naftaly W.en_US
dc.date.accessioned2023-12-05T13:11:33Zen_US
dc.date.available2023-12-05T13:11:33Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/135031en_US
dc.titleThe potential for use of haematological and anti-IgE humoral responses as phenotypic markers for tick resistance in cattleen_US
dcterms.abstractApproximately 80% of the global cattle population is at risk of infestation and infection by ticks and tick-borne diseases (TTBDs). The economic losses from animal mortality, reduced production, vector control costs and animal treatment are very substantial, hence there is an urgent need to develop and deploy alternative vector control strategies. Breeding for host tick resistance has the potential for sustainable large-scale TTBD control especially in cattle. The gold standard method for phenotyping tick resistance in cattle is by counting ticks on the body but is very laborious and subjective. Better methods for phenotyping tick resistance more objectively, faster and at scale, are essential for selecting host genetic resistance to ticks. This study investigated the correlation between haematological cellular profiles and immunological responses (immunoglobulin E, IgE) and full body tick counts in herds of <i>Bos indicus</i> and <i>Bos taurus</i> following artificial tick challenge with <i>Rhipicephalus decoloratus</i> larvae. Fifty-four Friesian and Ayrshire (<i>Bos taurus</i>) and 52 East African Zebu (<i>Bos indicus</i>) calves were each infested with ∼2500 larvae. Near-replete adult female ticks (≥4.5 mm) were counted daily from day 20–25. Blood and serum samples were obtained from each animal on days 0 and 23 for cellular blood and IgE titre analysis, respectively. The indicine cattle were refractory to <i>R. decoloratus</i> infestation in comparison with the taurine breed (<i>P </i>< 0.0001). Repeated measurements of blood components pre-infestation revealed a significant (<i>P </i>< 0.05) association with tick count in IgE and red blood cells, heamatocrit, and haemoglobin post-infestation. There was also a strong positive correlation between the tick counts and red blood cell numbers, haemoglobin, haematocrit, and IgE concentration (<i>P</i> < 0.0001) following tick challenge. The application of this approach to phenotype host resistance needs to be assessed using higher cattle numbers and with different tick species or genera.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceAcademicsen_US
dcterms.audienceScientistsen_US
dcterms.available2023-12-15en_US
dcterms.bibliographicCitationNgetich, C., Kamau, L., Simbauni, J., Mwendia, C., Owido, M., Kioo, I., Matika, O., Foster, S., Birkett, M., Djikeng, A., Watson, K.A. and Githaka, N. 2024. The potential for use of haematological and anti-IgE humoral responses as phenotypic markers for tick resistance in cattle. Current <i>Research in Parasitology & Vector-Borne Diseases</i> 5: 100159.en_US
dcterms.extent100159en_US
dcterms.issued2024-01en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-NC-ND-4.0en_US
dcterms.publisherElsevieren_US
dcterms.subjecttick-borne diseasesen_US
dcterms.subjectcattleen_US
dcterms.subjectdisease controlen_US
dcterms.typeJournal Articleen_US

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