Analysis of T-cell responses in cattle immunized against heartwater by vaccination with killed elementary bodies of Cowdria ruminantium
| cg.identifier.url | http://iai.asm.org/content/65/1/236.long | en |
| cg.issn | 0019-9567 | en |
| cg.issue | 1 | en |
| cg.journal | Infection and Immunity | en |
| cg.subject.ilri | ANIMAL DISEASES | en |
| cg.subject.ilri | DISEASE CONTROL | en |
| cg.subject.ilri | LIVESTOCK | en |
| cg.subject.ilri | VACCINES | en |
| cg.volume | 65 | en |
| dc.contributor.author | Totte, P. | en |
| dc.contributor.author | McKeever, Declan J. | en |
| dc.contributor.author | Martínez, D. | en |
| dc.contributor.author | Bensaid, A. | en |
| dc.date.accessioned | 2013-05-06T07:01:22Z | en |
| dc.date.available | 2013-05-06T07:01:22Z | en |
| dc.identifier.uri | https://hdl.handle.net/10568/28765 | |
| dc.title | Analysis of T-cell responses in cattle immunized against heartwater by vaccination with killed elementary bodies of Cowdria ruminantium | en |
| dcterms.abstract | Cattle were successfully immunized against heartwater with a lysate of Cowdria ruminantium formulated in Freund's adjuvant. Vaccinated animals proved fully resistant to virulent challenge 3 and 10 months after vaccination. For the first time a helper T lymphocyte response to Cowdria antigens was observed and characterized. Cowdria-specific T-cell lines generated from vaccinated animals by in vitro restimulation with Cowdria lysates are 95 to 100 percent CD4+, are MHC class II restricted, and produce gamma interferon. They proliferate in response to autologous monocytes infected with live Cowdria but not in response to uninfected monocytes. These T-cell lines will facilitate the search for Cowdria antigens that are immunogenic for T cells and will therefore be of relevance in the development of a subunit vaccine against the disease. | en |
| dcterms.accessRights | Limited Access | |
| dcterms.bibliographicCitation | Infection and Immunity;65(1): 236-241 | en |
| dcterms.extent | p. 236-241 | en |
| dcterms.issued | 1997 | |
| dcterms.language | en | |
| dcterms.subject | cowdria ruminantium | en |
| dcterms.subject | cattle | en |
| dcterms.subject | immunization | en |
| dcterms.subject | vaccination | en |
| dcterms.subject | cowdriosis | en |
| dcterms.type | Journal Article |