Serological and spatial analysis of alphavirus and flavivirus prevalence and risk factors in a rural community in western Kenya

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationStanford Universityen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationUniversity of Edinburghen
cg.contributor.affiliationMount Kenya Universityen
cg.contributor.affiliationKenya Medical Research Instituteen
cg.contributor.affiliationUniversity of Liverpoolen
cg.contributor.crpAgriculture for Nutrition and Health
cg.contributor.donorWellcome Trusten
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen
cg.contributor.donorEconomic and Social Research Council, United Kingdomen
cg.contributor.donorMedical Research Council, United Kingdomen
cg.contributor.donorNatural Environment Research Council, United Kingdomen
cg.contributor.donorDefence Science and Technology Laboratory, United Kingdomen
cg.contributor.donorNational Institutes of Health, United Statesen
cg.coverage.countryKenya
cg.coverage.iso3166-alpha2KE
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierElizabeth Cook: 0000-0001-6081-8363en
cg.creator.identifierWilliam de Glanville: 0000-0003-2474-0356en
cg.creator.identifierLian Thomas: 0000-0001-8447-1210en
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986en
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1371/journal.pntd.0005998en
cg.isijournalISI Journalen
cg.issn1935-2735en
cg.issue10en
cg.journalPLOS Neglected Tropical Diseasesen
cg.reviewStatusPeer Reviewen
cg.subject.ilriENVIRONMENTen
cg.subject.ilriHEALTHen
cg.volume11en
dc.contributor.authorGrossi-Soyster, E.N.en
dc.contributor.authorCook, Elizabeth A.J.en
dc.contributor.authorGlanville, William A. deen
dc.contributor.authorThomas, Lian F.en
dc.contributor.authorKrystosik, A.R.en
dc.contributor.authorLee, J.en
dc.contributor.authorWamae, C.N.en
dc.contributor.authorKariuki, S.en
dc.contributor.authorFèvre, Eric M.en
dc.contributor.authorLaBeaud, A.D.en
dc.date.accessioned2017-11-01T12:18:37Zen
dc.date.available2017-11-01T12:18:37Zen
dc.identifier.urihttps://hdl.handle.net/10568/89176
dc.titleSerological and spatial analysis of alphavirus and flavivirus prevalence and risk factors in a rural community in western Kenyaen
dcterms.abstractAlphaviruses, such as chikungunya virus, and flaviviruses, such as dengue virus, are (re)-emerging arboviruses that are endemic in tropical environments. In Africa, arbovirus infections are often undiagnosed and unreported, with febrile illnesses often assumed to be malaria. This cross-sectional study aimed to characterize the seroprevalence of alphaviruses and flaviviruses among children (ages 5–14, n = 250) and adults (ages 15 ≥ 75, n = 250) in western Kenya. Risk factors for seropositivity were explored using Lasso regression. Overall, 67% of participants showed alphavirus seropositivity (CI95 63%–70%), and 1.6% of participants showed flavivirus seropositivity (CI95 0.7%–3%). Children aged 10–14 were more likely to be seropositive to an alphavirus than adults (p < 0.001), suggesting a recent transmission period. Alphavirus and flavivirus seropositivity was detected in the youngest participants (age 5–9), providing evidence of inter-epidemic transmission. Demographic variables that were significantly different amongst those with previous infection versus those without infection included age, education level, and occupation. Behavioral and environmental variables significantly different amongst those in with previous infection to those without infection included taking animals for grazing, fishing, and recent village flooding. Experience of recent fever was also found to be a significant indicator of infection (p = 0.027). These results confirm alphavirus and flavivirus exposure in western Kenya, while illustrating significantly higher alphavirus transmission compared to previous studies.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.available2017-10-17en
dcterms.bibliographicCitationGrossi-Soyster, E.N., Cook, E.A.J., Glanville, W.A. de, Thomas, L.F., Krystosik, A.R., Lee, J., Wamae, C.N., Kariuki, S., Fèvre, E.M. and LaBeaud, A.D. 2017. Serological and spatial analysis of alphavirus and flavivirus prevalence and risk factors in a rural community in western Kenya. PLOS Neglected Tropical Diseases 11(10): e0005998.en
dcterms.issued2017-10-17en
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherPublic Library of Scienceen
dcterms.subjectenvironmenten
dcterms.subjecthealthen
dcterms.typeJournal Article

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