Serological and spatial analysis of alphavirus and flavivirus prevalence and risk factors in a rural community in western Kenya

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationStanford Universityen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationUniversity of Edinburghen_US
cg.contributor.affiliationMount Kenya Universityen_US
cg.contributor.affiliationKenya Medical Research Instituteen_US
cg.contributor.affiliationUniversity of Liverpoolen_US
cg.contributor.crpAgriculture for Nutrition and Healthen_US
cg.contributor.donorWellcome Trusten_US
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen_US
cg.contributor.donorEconomic and Social Research Council, United Kingdomen_US
cg.contributor.donorMedical Research Council, United Kingdomen_US
cg.contributor.donorNatural Environment Research Council, United Kingdomen_US
cg.contributor.donorDefence Science and Technology Laboratory, United Kingdomen_US
cg.contributor.donorNational Institutes of Health, United Statesen_US
cg.coverage.countryKenyaen_US
cg.coverage.iso3166-alpha2KEen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierElizabeth Cook: 0000-0001-6081-8363en_US
cg.creator.identifierWilliam de Glanville: 0000-0003-2474-0356en_US
cg.creator.identifierLian Thomas: 0000-0001-8447-1210en_US
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1371/journal.pntd.0005998en_US
cg.isijournalISI Journalen_US
cg.issn1935-2735en_US
cg.issue10en_US
cg.journalPLOS Neglected Tropical Diseasesen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.ilriENVIRONMENTen_US
cg.subject.ilriHEALTHen_US
cg.volume11en_US
dc.contributor.authorGrossi-Soyster, E.N.en_US
dc.contributor.authorCook, Elizabeth A.J.en_US
dc.contributor.authorGlanville, William A. deen_US
dc.contributor.authorThomas, Lian F.en_US
dc.contributor.authorKrystosik, A.R.en_US
dc.contributor.authorLee, J.en_US
dc.contributor.authorWamae, C.N.en_US
dc.contributor.authorKariuki, S.en_US
dc.contributor.authorFèvre, Eric M.en_US
dc.contributor.authorLaBeaud, A.D.en_US
dc.date.accessioned2017-11-01T12:18:37Zen_US
dc.date.available2017-11-01T12:18:37Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/89176en_US
dc.titleSerological and spatial analysis of alphavirus and flavivirus prevalence and risk factors in a rural community in western Kenyaen_US
dcterms.abstractAlphaviruses, such as chikungunya virus, and flaviviruses, such as dengue virus, are (re)-emerging arboviruses that are endemic in tropical environments. In Africa, arbovirus infections are often undiagnosed and unreported, with febrile illnesses often assumed to be malaria. This cross-sectional study aimed to characterize the seroprevalence of alphaviruses and flaviviruses among children (ages 5–14, n = 250) and adults (ages 15 ≥ 75, n = 250) in western Kenya. Risk factors for seropositivity were explored using Lasso regression. Overall, 67% of participants showed alphavirus seropositivity (CI95 63%–70%), and 1.6% of participants showed flavivirus seropositivity (CI95 0.7%–3%). Children aged 10–14 were more likely to be seropositive to an alphavirus than adults (p < 0.001), suggesting a recent transmission period. Alphavirus and flavivirus seropositivity was detected in the youngest participants (age 5–9), providing evidence of inter-epidemic transmission. Demographic variables that were significantly different amongst those with previous infection versus those without infection included age, education level, and occupation. Behavioral and environmental variables significantly different amongst those in with previous infection to those without infection included taking animals for grazing, fishing, and recent village flooding. Experience of recent fever was also found to be a significant indicator of infection (p = 0.027). These results confirm alphavirus and flavivirus exposure in western Kenya, while illustrating significantly higher alphavirus transmission compared to previous studies.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceScientistsen_US
dcterms.available2017-10-17en_US
dcterms.bibliographicCitationGrossi-Soyster, E.N., Cook, E.A.J., Glanville, W.A. de, Thomas, L.F., Krystosik, A.R., Lee, J., Wamae, C.N., Kariuki, S., Fèvre, E.M. and LaBeaud, A.D. 2017. Serological and spatial analysis of alphavirus and flavivirus prevalence and risk factors in a rural community in western Kenya. PLOS Neglected Tropical Diseases 11(10): e0005998.en_US
dcterms.issued2017-10-17en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherPublic Library of Scienceen_US
dcterms.subjectenvironmenten_US
dcterms.subjecthealthen_US
dcterms.typeJournal Articleen_US

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