The sero-epidemiology of Rift Valley fever in people in the Lake Victoria Basin of western Kenya

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationUniversity of Edinburghen
cg.contributor.affiliationStanford Universityen
cg.contributor.affiliationKenya Medical Research Instituteen
cg.contributor.affiliationMount Kenya Universityen
cg.contributor.affiliationUniversity of Liverpoolen
cg.contributor.crpAgriculture for Nutrition and Health
cg.contributor.donorMedical Research Council, United Kingdomen
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen
cg.contributor.donorPacific Northwest Regional Centre of Excellenceen
cg.contributor.donorWellcome Trusten
cg.contributor.donorEconomic and Social Research Council, United Kingdomen
cg.contributor.donorNatural Environment Research Council, United Kingdomen
cg.contributor.donorDefence Science and Technology Laboratory, United Kingdomen
cg.coverage.countryKenya
cg.coverage.iso3166-alpha2KE
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierElizabeth Cook: 0000-0001-6081-8363en
cg.creator.identifierWilliam de Glanville: 0000-0003-2474-0356en
cg.creator.identifierLian Thomas: 0000-0001-8447-1210en
cg.creator.identifierMark Bronsvoort: 0000-0002-3271-8485en
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986en
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1371/journal.pntd.0005731en
cg.isijournalISI Journalen
cg.issn1935-2735en
cg.issue7en
cg.journalPLOS Neglected Tropical Diseasesen
cg.reviewStatusPeer Reviewen
cg.subject.ilriCATTLEen
cg.subject.ilriEPIDEMIOLOGYen
cg.subject.ilriGOATSen
cg.subject.ilriHEALTHen
cg.subject.ilriLIVESTOCKen
cg.subject.ilriRVFen
cg.subject.ilriSMALL RUMINANTSen
cg.subject.ilriZOONOTIC DISEASESen
cg.volume11en
dc.contributor.authorCook, Elizabeth A.J.en
dc.contributor.authorGrossi-Soyster, E.N.en
dc.contributor.authorGlanville, William A. deen
dc.contributor.authorThomas, Lian F.en
dc.contributor.authorKariuki, S.en
dc.contributor.authorBronsvoort, B.M. de C.en
dc.contributor.authorWamae, C.N.en
dc.contributor.authorLaBeaud, A.D.en
dc.contributor.authorFèvre, Eric M.en
dc.date.accessioned2017-07-11T08:44:33Zen
dc.date.available2017-07-11T08:44:33Zen
dc.identifier.urihttps://hdl.handle.net/10568/82713
dc.titleThe sero-epidemiology of Rift Valley fever in people in the Lake Victoria Basin of western Kenyaen
dcterms.abstractRift Valley fever virus (RVFV) is a zoonotic arbovirus affecting livestock and people. This study was conducted in western Kenya where RVFV outbreaks have not previously been reported. The aims were to document the seroprevalence and risk factors for RVFV antibodies in a community-based sample from western Kenya and compare this with slaughterhouse workers in the same region who are considered a high-risk group for RVFV exposure. The study was conducted in western Kenya between July 2010 and November 2012. Individuals were recruited from randomly selected homesteads and a census of slaughterhouses. Structured questionnaire tools were used to collect information on demographic data, health, and risk factors for zoonotic disease exposure. Indirect ELISA on serum samples determined seropositivity to RVFV. Risk factor analysis for RVFV seropositivity was conducted using multi-level logistic regression. A total of 1861 individuals were sampled in 384 homesteads. The seroprevalence of RVFV in the community was 0.8% (95% CI 0.5–1.3). The variables significantly associated with RVFV seropositivity in the community were increasing age (OR 1.2; 95% CI 1.1–1.4, p<0.001), and slaughtering cattle at the homestead (OR 3.3; 95% CI 1.0–10.5, p = 0.047). A total of 553 slaughterhouse workers were sampled in 84 ruminant slaughterhouses. The seroprevalence of RVFV in slaughterhouse workers was 2.5% (95% CI 1.5–4.2). Being the slaughterman, the person who cuts the animal’s throat (OR 3.5; 95% CI 1.0–12.1, p = 0.047), was significantly associated with RVFV seropositivity. This study investigated and compared the epidemiology of RVFV between community members and slaughterhouse workers in western Kenya. The data demonstrate that slaughtering animals is a risk factor for RVFV seropositivity and that slaughterhouse workers are a high-risk group for RVFV seropositivity in this environment. These risk factors have been previously reported in other studies providing further evidence for RVFV circulation in western Kenya.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.available2017-07-07en
dcterms.bibliographicCitationCook, E.A.J., Grossi-Soyster, E.N., Glanville, W.A. de, Thomas, L.F., Kariuki, S., Bronsvoort, B.M. de C., Wamae, C.N., LaBeaud, A.D. and Fèvre, E.M. 2017. The sero-epidemiology of Rift Valley fever in people in the Lake Victoria Basin of western Kenya. PLOS Neglected Tropical Diseases 11(7): e0005731.en
dcterms.issued2017-07-07en
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherPublic Library of Scienceen
dcterms.subjectcattleen
dcterms.subjectepidemiologyen
dcterms.subjectgoatsen
dcterms.subjectsmall ruminantsen
dcterms.subjectlivestocken
dcterms.subjecthealthen
dcterms.subjectzoonosesen
dcterms.typeJournal Article

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