The sero-epidemiology of Rift Valley fever in people in the Lake Victoria Basin of western Kenya

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationUniversity of Edinburghen_US
cg.contributor.affiliationStanford Universityen_US
cg.contributor.affiliationKenya Medical Research Instituteen_US
cg.contributor.affiliationMount Kenya Universityen_US
cg.contributor.affiliationUniversity of Liverpoolen_US
cg.contributor.crpAgriculture for Nutrition and Healthen_US
cg.contributor.donorMedical Research Council, United Kingdomen_US
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen_US
cg.contributor.donorPacific Northwest Regional Centre of Excellenceen_US
cg.contributor.donorWellcome Trusten_US
cg.contributor.donorEconomic and Social Research Council, United Kingdomen_US
cg.contributor.donorNatural Environment Research Council, United Kingdomen_US
cg.contributor.donorDefence Science and Technology Laboratory, United Kingdomen_US
cg.coverage.countryKenyaen_US
cg.coverage.iso3166-alpha2KEen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierElizabeth Cook: 0000-0001-6081-8363en_US
cg.creator.identifierWilliam de Glanville: 0000-0003-2474-0356en_US
cg.creator.identifierLian Thomas: 0000-0001-8447-1210en_US
cg.creator.identifierMark Bronsvoort: 0000-0002-3271-8485en_US
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1371/journal.pntd.0005731en_US
cg.isijournalISI Journalen_US
cg.issn1935-2735en_US
cg.issue7en_US
cg.journalPLOS Neglected Tropical Diseasesen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.ilriCATTLEen_US
cg.subject.ilriEPIDEMIOLOGYen_US
cg.subject.ilriGOATSen_US
cg.subject.ilriHEALTHen_US
cg.subject.ilriLIVESTOCKen_US
cg.subject.ilriRVFen_US
cg.subject.ilriSMALL RUMINANTSen_US
cg.subject.ilriZOONOTIC DISEASESen_US
cg.volume11en_US
dc.contributor.authorCook, Elizabeth A.J.en_US
dc.contributor.authorGrossi-Soyster, E.N.en_US
dc.contributor.authorGlanville, William A. deen_US
dc.contributor.authorThomas, Lian F.en_US
dc.contributor.authorKariuki, S.en_US
dc.contributor.authorBronsvoort, B.M. de C.en_US
dc.contributor.authorWamae, C.N.en_US
dc.contributor.authorLaBeaud, A.D.en_US
dc.contributor.authorFèvre, Eric M.en_US
dc.date.accessioned2017-07-11T08:44:33Zen_US
dc.date.available2017-07-11T08:44:33Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/82713en_US
dc.titleThe sero-epidemiology of Rift Valley fever in people in the Lake Victoria Basin of western Kenyaen_US
dcterms.abstractRift Valley fever virus (RVFV) is a zoonotic arbovirus affecting livestock and people. This study was conducted in western Kenya where RVFV outbreaks have not previously been reported. The aims were to document the seroprevalence and risk factors for RVFV antibodies in a community-based sample from western Kenya and compare this with slaughterhouse workers in the same region who are considered a high-risk group for RVFV exposure. The study was conducted in western Kenya between July 2010 and November 2012. Individuals were recruited from randomly selected homesteads and a census of slaughterhouses. Structured questionnaire tools were used to collect information on demographic data, health, and risk factors for zoonotic disease exposure. Indirect ELISA on serum samples determined seropositivity to RVFV. Risk factor analysis for RVFV seropositivity was conducted using multi-level logistic regression. A total of 1861 individuals were sampled in 384 homesteads. The seroprevalence of RVFV in the community was 0.8% (95% CI 0.5–1.3). The variables significantly associated with RVFV seropositivity in the community were increasing age (OR 1.2; 95% CI 1.1–1.4, p<0.001), and slaughtering cattle at the homestead (OR 3.3; 95% CI 1.0–10.5, p = 0.047). A total of 553 slaughterhouse workers were sampled in 84 ruminant slaughterhouses. The seroprevalence of RVFV in slaughterhouse workers was 2.5% (95% CI 1.5–4.2). Being the slaughterman, the person who cuts the animal’s throat (OR 3.5; 95% CI 1.0–12.1, p = 0.047), was significantly associated with RVFV seropositivity. This study investigated and compared the epidemiology of RVFV between community members and slaughterhouse workers in western Kenya. The data demonstrate that slaughtering animals is a risk factor for RVFV seropositivity and that slaughterhouse workers are a high-risk group for RVFV seropositivity in this environment. These risk factors have been previously reported in other studies providing further evidence for RVFV circulation in western Kenya.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceScientistsen_US
dcterms.available2017-07-07en_US
dcterms.bibliographicCitationCook, E.A.J., Grossi-Soyster, E.N., Glanville, W.A. de, Thomas, L.F., Kariuki, S., Bronsvoort, B.M. de C., Wamae, C.N., LaBeaud, A.D. and Fèvre, E.M. 2017. The sero-epidemiology of Rift Valley fever in people in the Lake Victoria Basin of western Kenya. PLOS Neglected Tropical Diseases 11(7): e0005731.en_US
dcterms.issued2017-07-07en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherPublic Library of Scienceen_US
dcterms.subjectcattleen_US
dcterms.subjectepidemiologyen_US
dcterms.subjectgoatsen_US
dcterms.subjectsmall ruminantsen_US
dcterms.subjectlivestocken_US
dcterms.subjecthealthen_US
dcterms.subjectzoonosesen_US
dcterms.typeJournal Articleen_US

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