Molecular prevalence and risk factors associated with tick-borne pathogens in cattle in western Kenya

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationInternational Centre of Insect Physiology and Ecologyen
cg.contributor.affiliationUniversity of Pretoriaen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationUniversity of Liverpoolen
cg.contributor.crpAgriculture for Nutrition and Health
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen
cg.contributor.donorGovernment of the United Kingdomen
cg.contributor.donorEconomic and Social Research Council, United Kingdomen
cg.contributor.donorMedical Research Council, United Kingdomen
cg.contributor.donorNatural Environment Research Council, United Kingdomen
cg.contributor.donorDefence Science and Technology Laboratory, United Kingdomen
cg.contributor.donorEuropean Unionen
cg.contributor.donorSwedish International Development Cooperation Agencyen
cg.contributor.donorSwiss Agency for Development and Cooperationen
cg.contributor.donorGovernment of Ethiopiaen
cg.contributor.donorGovernment of Kenyaen
cg.contributor.donorDeutscher Akademischer Austauschdiensten
cg.coverage.countryKenya
cg.coverage.iso3166-alpha2KE
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986en
cg.creator.identifierLaura Cristina Falzon: 0000-0002-4043-1644en
cg.creator.identifierDaniel Masiga: 0000-0001-7513-0887en
cg.creator.identifierMaurice Murungi: 0000-0001-6467-4352en
cg.creator.identifierLillian Wambua: 0000-0003-3632-7411en
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1186/s12917-021-03074-7en
cg.isijournalISI Journalen
cg.issn1746-6148en
cg.issue1en
cg.journalBMC Veterinary Researchen
cg.reviewStatusPeer Reviewen
cg.subject.ilriANIMAL DISEASESen
cg.subject.ilriCATTLEen
cg.subject.ilriLIVESTOCKen
cg.subject.impactAreaNutrition, health and food security
cg.subject.sdgSDG 2 - Zero hungeren
cg.volume17en
dc.contributor.authorChiuya, T.en
dc.contributor.authorVillinger, J.en
dc.contributor.authorMasiga, D.K.en
dc.contributor.authorOndifu, D.O.en
dc.contributor.authorMurungi, Maurice K.en
dc.contributor.authorWambua, Lillianen
dc.contributor.authorBastos, A.D.S.en
dc.contributor.authorFèvre, Eric M.en
dc.contributor.authorFalzon, Laura C.en
dc.date.accessioned2021-11-30T07:09:34Zen
dc.date.available2021-11-30T07:09:34Zen
dc.identifier.urihttps://hdl.handle.net/10568/116387
dc.titleMolecular prevalence and risk factors associated with tick-borne pathogens in cattle in western Kenyaen
dcterms.abstractBackground Tick-borne pathogens (TBPs) are of global importance, especially in sub-Saharan Africa where they represent a major constraint to livestock production. Their association with human disease is also increasingly recognized, signalling their zoonotic importance. It is therefore crucial to investigate TBPs prevalence in livestock populations and the factors associated with their presence. We set out to identify TBPs present in cattle and to determine associated risk factors in western Kenya, where smallholder livestock production is important for subsistence and market-driven income. Results Tick-borne pathogen infections in blood samples collected from cattle at livestock markets and slaughterhouses between May 2017 and January 2019 were identified by high-resolution melting analysis and sequencing of PCR products of genus-specific primers. Of the 422 cattle sampled, 30.1% (127/422) were infected with at least one TBP, while 8.8% (37/422) had dual infections. Anaplasma spp. (19.7%) were the most prevalent, followed by Theileria (12.3%), Ehrlichia (6.6%), and Babesia (0.2%) spp. Sequence analysis of the TBPs revealed them to be Anaplasma platys-like organisms (13.5%), Theileria velifera (7.4%), Anaplasma marginale (4.9%), Theileria mutans (3.1%), Theileria parva (1.6%), and Babesia bigemina (0.2%). Ehrlichia ruminantium, Rickettsia spp., and arboviruses were not detected. Exotic breeds of cattle were more likely to be infected with A. marginale compared to local breeds (OR: 7.99, 95% CI: 3.04–22.02, p < 0.001). Presence of ticks was a significant predictor for Anaplasma spp. (OR: 2.18, 95% CI: 1.32–3.69, p = 0.003) and Ehrlichia spp. (OR: 2.79, 95% CI: 1.22–7.23, p = 0.022) infection. Cattle sampled at slaughterhouses were more likely to be positive for Anaplasma spp. (OR: 1.64, 95% CI: 1.01–2.70, p = 0.048) and A. marginale (OR: 3.84, 95% CI: 1.43–12.21, p = 0.012), compared to those sampled at livestock markets. Conclusion This study reports TBP prevalence and associated risk factors in western Kenya, factors which are key to informing surveillance and control measures.en
dcterms.accessRightsOpen Access
dcterms.audienceAcademicsen
dcterms.audienceScientistsen
dcterms.available2021-11-27en
dcterms.bibliographicCitationChiuya, T., Villinger, J., Masiga, D.K., Ondifu, D.O., Murungi, M.K., Wambua, L., Bastos, A.D.S., Fèvre, E.M. and Falzon, L.C. 2021. Molecular prevalence and risk factors associated with tick-borne pathogens in cattle in western Kenya. BMC Veterinary Research 17: 363.en
dcterms.extent363en
dcterms.issued2021-12en
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherSpringeren
dcterms.subjectcattleen
dcterms.subjectpathogensen
dcterms.subjectanimal diseasesen
dcterms.typeJournal Article

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