Molecular prevalence and risk factors associated with tick-borne pathogens in cattle in western Kenya

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationInternational Centre of Insect Physiology and Ecologyen_US
cg.contributor.affiliationUniversity of Pretoriaen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationUniversity of Liverpoolen_US
cg.contributor.crpAgriculture for Nutrition and Healthen_US
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen_US
cg.contributor.donorGovernment of the United Kingdomen_US
cg.contributor.donorEconomic and Social Research Council, United Kingdomen_US
cg.contributor.donorMedical Research Council, United Kingdomen_US
cg.contributor.donorNatural Environment Research Council, United Kingdomen_US
cg.contributor.donorDefence Science and Technology Laboratory, United Kingdomen_US
cg.contributor.donorEuropean Unionen_US
cg.contributor.donorSwedish International Development Cooperation Agencyen_US
cg.contributor.donorSwiss Agency for Development and Cooperationen_US
cg.contributor.donorGovernment of Ethiopiaen_US
cg.contributor.donorGovernment of Kenyaen_US
cg.contributor.donorDeutscher Akademischer Austauschdiensten_US
cg.coverage.countryKenyaen_US
cg.coverage.iso3166-alpha2KEen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986en_US
cg.creator.identifierLaura Cristina Falzon: 0000-0002-4043-1644en_US
cg.creator.identifierDaniel Masiga: 0000-0001-7513-0887en_US
cg.creator.identifierMaurice Murungi: 0000-0001-6467-4352en_US
cg.creator.identifierLillian Wambua: 0000-0003-3632-7411en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1186/s12917-021-03074-7en_US
cg.isijournalISI Journalen_US
cg.issn1746-6148en_US
cg.issue1en_US
cg.journalBMC Veterinary Researchen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.ilriANIMAL DISEASESen_US
cg.subject.ilriCATTLEen_US
cg.subject.ilriLIVESTOCKen_US
cg.subject.impactAreaNutrition, health and food securityen_US
cg.subject.sdgSDG 2 - Zero hungeren_US
cg.volume17en_US
dc.contributor.authorChiuya, T.en_US
dc.contributor.authorVillinger, J.en_US
dc.contributor.authorMasiga, D.K.en_US
dc.contributor.authorOndifu, D.O.en_US
dc.contributor.authorMurungi, Maurice K.en_US
dc.contributor.authorWambua, Lillianen_US
dc.contributor.authorBastos, A.D.S.en_US
dc.contributor.authorFèvre, Eric M.en_US
dc.contributor.authorFalzon, Laura C.en_US
dc.date.accessioned2021-11-30T07:09:34Zen_US
dc.date.available2021-11-30T07:09:34Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/116387en_US
dc.titleMolecular prevalence and risk factors associated with tick-borne pathogens in cattle in western Kenyaen_US
dcterms.abstractBackground Tick-borne pathogens (TBPs) are of global importance, especially in sub-Saharan Africa where they represent a major constraint to livestock production. Their association with human disease is also increasingly recognized, signalling their zoonotic importance. It is therefore crucial to investigate TBPs prevalence in livestock populations and the factors associated with their presence. We set out to identify TBPs present in cattle and to determine associated risk factors in western Kenya, where smallholder livestock production is important for subsistence and market-driven income. Results Tick-borne pathogen infections in blood samples collected from cattle at livestock markets and slaughterhouses between May 2017 and January 2019 were identified by high-resolution melting analysis and sequencing of PCR products of genus-specific primers. Of the 422 cattle sampled, 30.1% (127/422) were infected with at least one TBP, while 8.8% (37/422) had dual infections. Anaplasma spp. (19.7%) were the most prevalent, followed by Theileria (12.3%), Ehrlichia (6.6%), and Babesia (0.2%) spp. Sequence analysis of the TBPs revealed them to be Anaplasma platys-like organisms (13.5%), Theileria velifera (7.4%), Anaplasma marginale (4.9%), Theileria mutans (3.1%), Theileria parva (1.6%), and Babesia bigemina (0.2%). Ehrlichia ruminantium, Rickettsia spp., and arboviruses were not detected. Exotic breeds of cattle were more likely to be infected with A. marginale compared to local breeds (OR: 7.99, 95% CI: 3.04–22.02, p < 0.001). Presence of ticks was a significant predictor for Anaplasma spp. (OR: 2.18, 95% CI: 1.32–3.69, p = 0.003) and Ehrlichia spp. (OR: 2.79, 95% CI: 1.22–7.23, p = 0.022) infection. Cattle sampled at slaughterhouses were more likely to be positive for Anaplasma spp. (OR: 1.64, 95% CI: 1.01–2.70, p = 0.048) and A. marginale (OR: 3.84, 95% CI: 1.43–12.21, p = 0.012), compared to those sampled at livestock markets. Conclusion This study reports TBP prevalence and associated risk factors in western Kenya, factors which are key to informing surveillance and control measures.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceAcademicsen_US
dcterms.audienceScientistsen_US
dcterms.available2021-11-27en_US
dcterms.bibliographicCitationChiuya, T., Villinger, J., Masiga, D.K., Ondifu, D.O., Murungi, M.K., Wambua, L., Bastos, A.D.S., Fèvre, E.M. and Falzon, L.C. 2021. Molecular prevalence and risk factors associated with tick-borne pathogens in cattle in western Kenya. BMC Veterinary Research 17: 363.en_US
dcterms.extent363en_US
dcterms.issued2021-12en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherSpringeren_US
dcterms.subjectcattleen_US
dcterms.subjectpathogensen_US
dcterms.subjectanimal diseasesen_US
dcterms.typeJournal Articleen_US

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