Theileria parasites subvert E2F signaling to stimulate leukocyte proliferation

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cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationUniversity of Marylanden_US
cg.contributor.affiliationUniversité de Paris Descartesen_US
cg.contributor.affiliationCochin Instituteen_US
cg.contributor.affiliationWashington State Universityen_US
cg.contributor.affiliationKing Abdullah University of Science and Technologyen_US
cg.contributor.affiliationUnited States Department of Agricultureen_US
cg.contributor.affiliationWeizmann Institute of Scienceen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationBar-Ilan Universityen_US
cg.contributor.affiliationSwiss Tropical and Public Health Instituteen_US
cg.contributor.affiliationUniversity of Baselen_US
cg.contributor.crpLivestocken_US
cg.contributor.donorUnited States Department of Agricultureen_US
cg.contributor.donorNorman Borlaug Commemorative Research Initiativeen_US
cg.contributor.donorUnited States Agency for International Developmenten_US
cg.contributor.donorDepartment for International Development, United Kingdomen_US
cg.contributor.donorBill & Melinda Gates Foundationen_US
cg.creator.identifierVishvanath Nene: 0000-0001-7066-4169en_US
cg.creator.identifierRichard Bishop: 0000-0002-3720-9970en_US
cg.creator.identifierClaudia Daubenberger: 0000-0001-7136-0642en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1038/s41598-020-60939-xen_US
cg.isijournalISI Journalen_US
cg.issn2045-2322en_US
cg.issue1en_US
cg.journalScientific Reportsen_US
cg.reviewStatusPeer Reviewen_US
cg.speciesTheileria parvaen_US
cg.subject.ilriANIMAL DISEASESen_US
cg.subject.ilriCATTLEen_US
cg.subject.ilriDISEASE CONTROLen_US
cg.subject.ilriECFen_US
cg.subject.ilriLIVESTOCKen_US
cg.subject.ilriVACCINESen_US
cg.volume10en_US
dc.contributor.authorTretina, Kyleen_US
dc.contributor.authorHaidar, M.en_US
dc.contributor.authorMadsen-Bouterse, S.A.en_US
dc.contributor.authorSakura, T.en_US
dc.contributor.authorMfarrej, S.en_US
dc.contributor.authorFry, L.M.en_US
dc.contributor.authorChaussepied, M.en_US
dc.contributor.authorPain, A.en_US
dc.contributor.authorKnowles, Donald P.en_US
dc.contributor.authorNene, Vishvanath M.en_US
dc.contributor.authorGinsberg, D.en_US
dc.contributor.authorDaubenberger, C.A.en_US
dc.contributor.authorBishop, Richard P.en_US
dc.contributor.authorLangsley, G.en_US
dc.contributor.authorSilva, Joana C.en_US
dc.date.accessioned2020-04-29T13:47:57Zen_US
dc.date.available2020-04-29T13:47:57Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/108093en_US
dc.titleTheileria parasites subvert E2F signaling to stimulate leukocyte proliferationen_US
dcterms.abstractIntracellular pathogens have evolved intricate mechanisms to subvert host cell signaling pathways and ensure their own propagation. A lineage of the protozoan parasite genus Theileria infects bovine leukocytes and induces their uncontrolled proliferation causing a leukemia-like disease. Given the importance of E2F transcription factors in mammalian cell cycle regulation, we investigated the role of E2F signaling in Theileria-induced host cell proliferation. Using comparative genomics and surface plasmon resonance, we identified parasite-derived peptides that have the sequence-specific ability to increase E2F signaling by binding E2F negative regulator Retinoblastoma-1 (RB). Using these peptides as a tool to probe host E2F signaling, we show that the disruption of RB complexes ex vivo leads to activation of E2F-driven transcription and increased leukocyte proliferation in an infection-dependent manner. This result is consistent with existing models and, together, they support a critical role of E2F signaling for Theileria-induced host cell proliferation, and its potential direct manipulation by one or more parasite proteins.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceScientistsen_US
dcterms.available2020-03-04en_US
dcterms.bibliographicCitationTretina, K., Haidar, M., Madsen-Bouterse, S.A., Sakura, T., Mfarrej, S., Fry, L., Chaussepied, M., Pain, A., Knowles, D.P., Nene, V.M., Ginsberg, D., Daubenberger, C.A., Bishop, R.P., Langsley, G. and Silva, J.C. 2020. Theileria parasites subvert E2F signaling to stimulate leukocyte proliferation. Scientific Reports 10: 3982.en_US
dcterms.issued2020-03-04en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherSpringeren_US
dcterms.subjecttheileriaen_US
dcterms.subjectcattleen_US
dcterms.subjectanimal diseasesen_US
dcterms.subjectvaccinesen_US
dcterms.subjectdisease controlen_US
dcterms.subjecteast coast feveren_US
dcterms.typeJournal Articleen_US

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