A locus conferring tolerance to Theileria infection in African cattle

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cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationCentre for Tropical Livestock Genetics and Healthen
cg.contributor.affiliationUniversity of Edinburghen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationUniversity of Glasgowen
cg.contributor.crpLivestock
cg.contributor.donorForeign, Commonwealth and Development Office, United Kingdomen
cg.contributor.donorBill & Melinda Gates Foundationen
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierElizabeth Cook: 0000-0001-6081-8363en
cg.creator.identifierPerle LATRE DE LATE: 0000-0003-3871-6277en
cg.creator.identifierTatjana Sitt: 0000-0001-7104-2345en
cg.creator.identifierJohanneke Dinie Hemmink: 0000-0001-8764-4156en
cg.creator.identifierMaurine Chepkwony Makau: 0000-0002-7684-6171en
cg.creator.identifierRegina Njeru: 0000-0001-9828-2621en
cg.creator.identifierElizabeth Jane Poole: 0000-0002-8570-794Xen
cg.creator.identifierAntoinette Aluoch: 0000-0001-7197-7837en
cg.creator.identifierPhilip Toye: 0000-0002-7100-2789en
cg.creator.identifierKaren Marshall: 0000-0003-4197-1455en
cg.creator.identifierMark Bronsvoort: 0000-0002-3271-8485en
cg.creator.identifierJames Prendergast: 0000-0001-8916-018Xen
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1371/journal.pgen.1010099en
cg.isijournalISI Journalen
cg.issn1553-7404en
cg.issue4en
cg.journalPLOS Geneticsen
cg.reviewStatusPeer Reviewen
cg.subject.ilriANIMAL DISEASESen
cg.subject.ilriCATTLEen
cg.subject.ilriDISEASE CONTROLen
cg.subject.ilriECFen
cg.volume18en
dc.contributor.authorWragg, D.en
dc.contributor.authorCook, Elizabeth A.J.en
dc.contributor.authorLatré de Laté, Perleen
dc.contributor.authorSitt, Tatjanaen
dc.contributor.authorHemmink, Johanneke D.en
dc.contributor.authorChepkwony, Maurine C.en
dc.contributor.authorNjeru, Reginaen
dc.contributor.authorPoole, Elizabeth J.en
dc.contributor.authorPowell, J.en
dc.contributor.authorPaxton, E.A.en
dc.contributor.authorCallaby, R.en
dc.contributor.authorTalenti, A.en
dc.contributor.authorMiyunga, Antoinetteen
dc.contributor.authorNdambuki, Gideon M.en
dc.contributor.authorMwaura, Stephenen
dc.contributor.authorAuty, H.en
dc.contributor.authorMatika, O.en
dc.contributor.authorHassan, M.en
dc.contributor.authorMarshall, Karenen
dc.contributor.authorConnelley, T.en
dc.contributor.authorMorrison, L.J.en
dc.contributor.authorBronsvoort, B.M. de C.en
dc.contributor.authorMorrison, W.I.en
dc.contributor.authorToye, Philip G.en
dc.contributor.authorPrendergast, J.G.D.en
dc.date.accessioned2022-04-28T12:59:49Zen
dc.date.available2022-04-28T12:59:49Zen
dc.identifier.urihttps://hdl.handle.net/10568/119413
dc.titleA locus conferring tolerance to Theileria infection in African cattleen
dcterms.abstractEast Coast fever, a tick-borne cattle disease caused by the Theileria parva parasite, is among the biggest natural killers of cattle in East Africa, leading to over 1 million deaths annually. Here we report on the genetic analysis of a cohort of Bos indicus (Boran) cattle demonstrating heritable tolerance to infection with T. parva (h2 = 0.65, s.e. 0.57). Through a linkage analysis we identify a 6 Mb genomic region on bovine chromosome 15 that is significantly associated with survival outcome following T. parva exposure. Testing this locus in an independent cohort of animals replicates this association with survival following T. parva infection. A stop gained variant in a paralogue of the FAF1 gene in this region was found to be highly associated with survival across both related and unrelated animals, with only one of the 20 homozygote carriers (T/T) of this change succumbing to the disease in contrast to 44 out of 97 animals homozygote for the reference allele (C/C). Consequently, we present a genetic locus linked to tolerance of one of Africa’s most important cattle diseases, raising the promise of marker-assisted selection for cattle that are less susceptible to infection by T. parva.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.available2022-04-21en
dcterms.bibliographicCitationWragg, D., Cook, E.A.J., Latre de Late, P., SittI, T., Hemmink, J.D., Chepkwony, M.C., Njeru, R., Poole, E.J., Powell, J., Paxton, E.A., Callaby, R., Talenti, A., Miyunga, A.A., Ndambuki, G., Mwaura, S., Auty, H., Matika, O., Hassan, M., Marshall, K., Connelley, T., Morrison, L.J., Bronsvoort, B.M. de C., Morrison, W.I., Toye, P.G. and Prendergast, J.G.D. 2022. A locus conferring tolerance to Theileria infection in African cattle. PLOS Genetics 18(4):e1010099.en
dcterms.issued2022-04-21en
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherPublic Library of Scienceen
dcterms.subjecteast coast feveren
dcterms.subjectanimal diseasesen
dcterms.subjectdisease controlen
dcterms.subjecttheileria parvaen
dcterms.subjectcattleen
dcterms.typeJournal Article

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