The sero-epidemiology of Coxiella burnetii in humans and cattle, western Kenya: Evidence from a cross-sectional study

Simple item page
cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationUniversity of Southamptonen_US
cg.contributor.affiliationUniversity of Edinburghen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationUniversity of Glasgowen_US
cg.contributor.affiliationLancaster Universityen_US
cg.contributor.affiliationQueen's University Belfasten_US
cg.contributor.affiliationKenya Medical Research Instituteen_US
cg.contributor.affiliationMount Kenya Universityen_US
cg.contributor.affiliationUniversity of Liverpoolen_US
cg.contributor.crpAgriculture for Nutrition and Healthen_US
cg.contributor.donorWellcome Trusten_US
cg.contributor.donorMedical Research Council, United Kingdomen_US
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen_US
cg.contributor.donorDepartment for International Development, United Kingdomen_US
cg.contributor.donorEconomic and Social Research Council, United Kingdomen_US
cg.contributor.donorNatural Environment Research Council, United Kingdomen_US
cg.contributor.donorDefence Science and Technology Laboratory, United Kingdomen_US
cg.coverage.countryKenyaen_US
cg.coverage.iso3166-alpha2KEen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierLian Thomas: 0000-0001-8447-1210en_US
cg.creator.identifierElizabeth Cook: 0000-0001-6081-8363en_US
cg.creator.identifierWilliam de Glanville: 0000-0003-2474-0356en_US
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1371/journal.pntd.0005032en_US
cg.isijournalISI Journalen_US
cg.issn1935-2735en_US
cg.issue10en_US
cg.journalPLOS Neglected Tropical Diseasesen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.ilriANIMAL DISEASESen_US
cg.subject.ilriCATTLEen_US
cg.subject.ilriEPIDEMIOLOGYen_US
cg.subject.ilriHEALTHen_US
cg.subject.ilriLIVESTOCKen_US
cg.subject.ilriZOONOTIC DISEASESen_US
cg.volume10en_US
dc.contributor.authorWardrop, N.A.en_US
dc.contributor.authorThomas, Lian F.en_US
dc.contributor.authorCook, Elizabeth A.J.en_US
dc.contributor.authorGlanville, William A. deen_US
dc.contributor.authorAtkinson, P.M.en_US
dc.contributor.authorWamae, C.N.en_US
dc.contributor.authorFèvre, Eric M.en_US
dc.date.accessioned2016-10-13T07:05:56Zen_US
dc.date.available2016-10-13T07:05:56Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/77258en_US
dc.titleThe sero-epidemiology of Coxiella burnetii in humans and cattle, western Kenya: Evidence from a cross-sectional studyen_US
dcterms.abstractEvidence suggests that the intracellular bacterial pathogen Coxiella burnetii (which causes Q fever) is widespread, with a near global distribution. While there has been increasing attention to Q fever epidemiology in high-income settings, a recent systematic review highlighted significant gaps in our understanding of the prevalence, spatial distribution and risk factors for Q fever infection across Africa. This research aimed to provide a One Health assessment of Q fever epidemiology in parts of Western and Nyanza Provinces, Western Kenya, in cattle and humans. A cross-sectional survey was conducted: serum samples from 2049 humans and 955 cattle in 416 homesteads were analysed for C. burnetii antibodies. Questionnaires covering demographic, socio-economic and husbandry information were also administered. These data were linked to environmental datasets based on geographical locations (e.g., land cover). Correlation and spatial-cross correlation analyses were applied to assess the potential link between cattle and human seroprevalence. Multilevel regression analysis was used to assess the relationships between a range of socio-economic, demographic and environmental factors and sero-positivity in both humans and animals. The overall sero-prevalence of C. burnetii was 2.5% in humans and 10.5% in cattle, but we found no evidence of correlation between cattle and human seroprevalence either within households, or when incorporating spatial proximity to other households in the survey. Multilevel modelling indicated the importance of several factors for exposure to the organism. Cattle obtained from market (as opposed to those bred in their homestead) and those residing in areas with lower precipitation levels had the highest sero-prevalence. For humans, the youngest age group had the highest odds of seropositivity, variations were observed between ethnic groups, and frequent livestock contact (specifically grazing and dealing with abortion material) was also a risk factor. These results illustrate endemicity of C. burnetii in western Kenya, although prevalence is relatively low. The analysis indicates that while environmental factors may play a role in cattle exposure patterns, human exposure patterns are likely to be driven more strongly by livestock contacts. The implication of livestock markets in cattle exposure risks suggests these may be a suitable target for interventions.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceScientistsen_US
dcterms.available2016-10-07en_US
dcterms.bibliographicCitationWardrop, N.A., Thomas, L.F., Cook, E.A.J., Glanville, W.A. de, Atkinson, P.M., Wamae, C.N. and Fèvre, E.M. 2016. The sero-epidemiology of Coxiella burnetii in humans and cattle, western Kenya: Evidence from a cross-sectional study. PLOS Neglected Tropical Diseases 10(10): e0005032.en_US
dcterms.issued2016-10-07en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherPublic Library of Scienceen_US
dcterms.subjectanimal diseasesen_US
dcterms.subjectzoonosesen_US
dcterms.subjecthealthen_US
dcterms.typeJournal Articleen_US

Files

License bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.89 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ILRI articles in journals
CRP A4NH outputs
ILRI animal bioscience program outputs
People, animals and their zoonoses
Zoonoses in Livestock in Kenya (ZooLinK)