Efficacy of bentonite and fumonisin esterase in mitigating the effects of aflatoxins and fumonisins in two Kenyan cattle breeds

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationGhent Universityen_US
cg.contributor.affiliationUniversity of Nairobien_US
cg.contributor.affiliationUniversity of Liègeen_US
cg.contributor.affiliationDSM-BIOMIN Research Center, Austriaen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationSwedish University of Agricultural Sciencesen_US
cg.contributor.affiliationUppsala Universityen_US
cg.contributor.donorMinistry of Education, Science and Technology, Kenyaen_US
cg.contributor.donorBelgian National Fund for Scientific Researchen_US
cg.contributor.donorBelgian Science Policy Officeen_US
cg.contributor.donorResearch Council of Norwayen_US
cg.contributor.donorNational Research Foundation, South Africaen_US
cg.coverage.countryKenyaen_US
cg.coverage.iso3166-alpha2KEen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierJohanna Lindahl: 0000-0002-1175-0398en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1021/acs.jafc.2c08217en_US
cg.isijournalISI Journalen_US
cg.issn1520-5118en_US
cg.issue4en_US
cg.journalJournal of Agricultural and Food Chemistryen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.ilriCATTLEen_US
cg.subject.ilriAFLATOXINSen_US
cg.volume71en_US
dc.contributor.authorKemboi, D.en_US
dc.contributor.authorAntonissen, G.en_US
dc.contributor.authorOchieng, P.en_US
dc.contributor.authorCroubels, S.en_US
dc.contributor.authorBaere, S. deen_US
dc.contributor.authorScippo, M.-L.en_US
dc.contributor.authorOkoth, Sheila A.en_US
dc.contributor.authorKang'ethe, Erastus K.en_US
dc.contributor.authorFaas, J.en_US
dc.contributor.authorDoupovec, B.en_US
dc.contributor.authorLindahl, Johanna F.en_US
dc.contributor.authorGathumbi, J.en_US
dc.date.accessioned2023-01-18T20:14:41Zen_US
dc.date.available2023-01-18T20:14:41Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/127457en_US
dc.titleEfficacy of bentonite and fumonisin esterase in mitigating the effects of aflatoxins and fumonisins in two Kenyan cattle breedsen_US
dcterms.abstractThe objective of the study was to investigate the efficacy of bentonite and fumonisin esterase, separately or combined, in mitigating the effects of aflatoxins (AF) and fumonisins (FUM) in Boran and Friesian-Boran crossbreed cattle. These effects were studied by measuring mycotoxins, their metabolites, and biomarkers that relate to animal health, productivity, and food safety. The study was divided into three experiments each lasting for 2 weeks. Cows in experiment 1 received in random order aflatoxin B1 (AFB1) [788 μg/cow/day (69.7 μg/kg dry matter intake (DMI)) for Borans and 2,310 μg/cow/day (154 μg/kg DMI) for crossbreeds], bentonite (60 g/cow/day), or both AFB1 and bentonite. Boran cows in experiment 2 received in random order FUM (12.4 mg/cow/day (1.1 mg/kg DMI)), fumonisin esterase (120 U/cow/day), or both FUM and fumonisin esterase. Boran cows in experiment 3 received in random order AFB1 (952 μg/cow/day (84.2 μg/kg DMI)) + FUM (30.4 mg/cow/day (2.7 mg/kg DMI)), bentonite (60 g/cow/day) + fumonisin esterase (120 U/cow/day), or both AFB1 + FUM and bentonite + fumonisin esterase. Feeding AFB1 and/or FUM contaminated feed with or without the addition of the detoxifiers for 14 days did not affect DMI, milk composition, hematology, and blood biochemical parameters. The addition of bentonite in a diet contaminated with AFB1 led to a decrease in milk aflatoxin M1 (AFM1) concentration of 30% and 43%, with the carry-over subsequently decreasing from 0.35% to 0.20% and 0.08% to 0.06% for crosses and Borans, respectively. No significant change was observed in the sphinganine/sphingosine (Sa/So) ratio following feeding with FUM alone or in combination with fumonisin esterase; however, the ability of fumonisin esterase to hydrolyze FUM into less toxic fully hydrolyzed FUM and partially hydrolyzed FUM was evident in the rumen fluid and feces. These results indicate bentonite was effective in decreasing AFM1 concentration in milk, and AFB1 and AFM1 in plasma, while fumonisin esterase can convert FUM into less toxic metabolites and can be a suitable addition to feed cocontaminated with AFB1 and FUM.en_US
dcterms.accessRightsLimited Accessen_US
dcterms.audienceScientistsen_US
dcterms.available2023-01-17en_US
dcterms.bibliographicCitationKemboi, D., Antonissen, G., Ochieng, P., Croubels, S., De Baere, S., Scippo, M.-L., Okoth, S., Kang'ethe, E., Faas, J., Doupovec, B., Lindahl, J. and Gathumbi, J. 2023. Efficacy of bentonite and fumonisin esterase in mitigating the effects of aflatoxins and fumonisins in two Kenyan cattle breeds. Journal of Agricultural and Food Chemistry 71(4): 2143–2151.en_US
dcterms.extent2143-2151en_US
dcterms.issued2023-02-01en_US
dcterms.languageenen_US
dcterms.licenseOtheren_US
dcterms.publisherAmerican Chemical Societyen_US
dcterms.subjectbentoniteen_US
dcterms.subjectfumonisinsen_US
dcterms.subjectaflatoxinsen_US
dcterms.subjectcattleen_US
dcterms.typeJournal Articleen_US

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