Sero-prevalence and risk factors associated with occurrence of anti-Brucella antibodies among slaughterhouse workers in Uganda

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationNational Livestock Resources Research Institute, Ugandaen_US
cg.contributor.affiliationMakerere Universityen_US
cg.contributor.affiliationUniversity of Bernen_US
cg.contributor.affiliationFreie Universität Berlinen_US
cg.contributor.affiliationUniversidad de Navarraen_US
cg.contributor.crpAgriculture for Nutrition and Healthen_US
cg.contributor.crpLivestocken_US
cg.contributor.donorFederal Ministry for Economic Cooperation and Development, Germanyen_US
cg.contributor.donorMakerere Universityen_US
cg.coverage.countryUgandaen_US
cg.coverage.iso3166-alpha2UGen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierJames Bugeza: 0000-0002-8124-2807en_US
cg.creator.identifierKristina Roesel: 0000-0002-2553-1129en_US
cg.creator.identifierLordrick Alinaitwe: 0000-0002-5432-6407en_US
cg.creator.identifierVelma Kivali: 0000-0003-0797-4484en_US
cg.creator.identifierElizabeth Cook: 0000-0001-6081-8363en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1371/journal.pntd.0012046en_US
cg.isijournalISI Journalen_US
cg.issn1935-2735en_US
cg.issue3en_US
cg.journalPLOS Neglected Tropical Diseasesen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.actionAreaResilient Agrifood Systemsen_US
cg.subject.ilriBRUCELLOSISen_US
cg.subject.ilriZOONOTIC DISEASESen_US
cg.subject.impactAreaNutrition, health and food securityen_US
cg.subject.impactPlatformNutrition, Health and Food Securityen_US
cg.subject.sdgSDG 3 - Good health and well-beingen_US
cg.volume18en_US
dc.contributor.authorBugeza, Jamesen_US
dc.contributor.authorRoesel, Kristinaen_US
dc.contributor.authorMugizi, Denisen_US
dc.contributor.authorAlinaitwe, Lordricken_US
dc.contributor.authorKivali, Velmaen_US
dc.contributor.authorKankya, C.en_US
dc.contributor.authorMoriyon, I.en_US
dc.contributor.authorCook, Elizabeth A.J.en_US
dc.date.accessioned2024-03-21T08:46:37Zen_US
dc.date.available2024-03-21T08:46:37Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/140533en_US
dc.titleSero-prevalence and risk factors associated with occurrence of anti-Brucella antibodies among slaughterhouse workers in Ugandaen_US
dcterms.abstract<b>Introduction</b> Brucellosis is a febrile zoonosis occurring among high-risk groups such as livestock keepers and abattoir workers and is a public health priority in Uganda. The technical complexities of bacteriological and molecular methods make serological approaches the cornerstone of diagnosis of human brucellosis in resource limited settings. Therefore, proper application and interpretation of serological tests is central to achieve a correct diagnosis. <b>Materials and methods</b> We conducted a cross-sectional study to estimate the seroprevalence and factors associated with anti-<i>Brucella</i> antibodies among slaughterhouse workers processing ruminants and pigs in three regions of the country with serial testing using a combination of the Rose Bengal Test (RBT) and the BrucellaCapt test. An authorized clinician collected 543 blood samples from consenting abattoir workers as well as attribute medical and social demographic data. Univariable and multivariable logistic regression were used to determine factors associated with anti-<i>Brucella</i> sero-positivity. <b>Results and discussion</b> The sero-prevalence among ruminant slaughterhouse workers ranged from 7.3% (95% CI: 4.8–10.7) using BrucellaCapt to 9.0% (95% CI: 6.3–12.7) using RBT. Slaughterhouse workers from the Eastern regions (AOR = 9.84, 95%CI 2.27–69.2, p = 0.006) and those who graze animals for alternative income (AOR = 2.36, 95% CI: 1.91–6.63, p = 0.040) were at a higher risk of exposure to <i>Brucella</i>. Similarly, those who wore Personal Protective Equipment (AOR = 4.83, 95%CI:1.63–18.0, p = 0.009) and those who slaughter cattle (AOR = 2.12, 95%CI: 1.25–6.0, p = 0.006) were at a higher risk of exposure to <i>Brucella</i>. Those who slaughter small ruminants (AOR = 1.54, 95%CI: 1.32–4.01, p = 0.048) were also at a higher risk of exposure to <i>Brucella</i>. <b>Conclusions and recommendations</b> Our study demonstrates the combined practical application of the RBT and BrucellaCapt in the diagnosis of human brucellosis in endemic settings. Both pharmaceutical (e.g., routine testing and timely therapeutic intervention), and non-pharmaceutical (e.g., higher index of suspicion of brucellosis when investigating fevers of unknown origin and observation of strict abattoir hygiene) countermeasures should be considered for control of the disease in high-risk groups.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceAcademicsen_US
dcterms.audienceScientistsen_US
dcterms.available2024-03-18en_US
dcterms.bibliographicCitationBugeza, J.K., Roesel, K., Mugizi, D.R., Alinaitwe, L., Kivali, V., Kankya, C., Moriyon, I. and Cook, E.A.J. 2024. Sero-prevalence and risk factors associated with occurrence of anti-<i>Brucella</i> antibodies among slaughterhouse workers in Uganda. <i>PLOS Neglected Tropical Diseases</i> 18(3): e0012046.en_US
dcterms.extente0012046en_US
dcterms.issued2024-03-18en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherPublic Library of Scienceen_US
dcterms.subjectbrucellosisen_US
dcterms.subjectzoonosesen_US
dcterms.typeJournal Articleen_US

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