Low level aflatoxin exposure associated with greater linear growth in southern Mexico: A longitudinal study

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cg.authorship.typesCGIAR single centreen
cg.authorship.typesCGIAR and developing country instituteen
cg.contributor.crpAgriculture for Nutrition and Health
cg.contributor.donorInternational Fund for Agricultural Developmenten
cg.contributor.donorProsperaen
cg.contributor.donorProspera Programa de Inclusión Socialen
cg.contributor.donorEuropean Unionen
cg.coverage.countryMexico
cg.coverage.iso3166-alpha2MX
cg.coverage.regionNorthern America
cg.coverage.regionLatin America
cg.coverage.regionCentral America
cg.creator.identifierJef L Leroy: 0000-0001-9371-3832
cg.creator.identifierCeleste Sununtnasuk: 0000-0002-2332-7386
cg.identifier.doihttps://doi.org/10.1111/mcn.12619en
cg.identifier.projectIFPRI - Poverty, Health, and Nutrition Division
cg.identifier.publicationRankA
cg.isijournalISI Journalen
cg.issn1740-8695en
cg.issn1740-8709en
cg.issue4en
cg.journalMaternal and Child Nutritionen
cg.reviewStatusPeer Reviewen
cg.volume14en
dc.contributor.authorLeroy, Jef L.en
dc.contributor.authorSununtnasuk, Celesteen
dc.contributor.authorGarcia-Guerra, Armandoen
dc.contributor.authorWang, Jia-Shengen
dc.date.accessioned2024-06-21T09:13:42Zen
dc.date.available2024-06-21T09:13:42Zen
dc.identifier.urihttps://hdl.handle.net/10568/147374
dc.titleLow level aflatoxin exposure associated with greater linear growth in southern Mexico: A longitudinal studyen
dcterms.abstractAflatoxins are a group of naturally occurring mycotoxins, which can lead to death and are a known cause of hepatocellular carcinoma. AF exposure has been hypothesised to lead to stunted growth in children, but separating the AF effect from other determinants of linear growth retardation is difficult. The study used secondary data from an efficacy trial conducted in young children in southern Mexico to test the comparative efficacy of a milk‐based multiple micronutrient‐fortified food, a multiple micronutrient syrup, or a multiple micronutrient powder. The effect of serum AFB1‐lysine adduct level on incremental growth was tested using a longitudinal mixed model, controlling for key individual, maternal, and household‐level covariates. AFB1‐lysine adduct was detectable in all but 2 of the 347 children in the study (median exposure: 0.82 pg/mg albumin). AF exposure was associated (p < .05) with greater linear growth: an increase equivalent to the sample interquartile range (~0.5 pg AFB1‐lysine/mg albumin) was associated (p < .05) with an increase in the child's height‐for‐age deficit of 1.5 to 2.0 mm in the 4 months from baseline (average age 8 months) to follow‐up (average age 12 months); the magnitude of the difference in the 10‐month follow‐up was smaller and not statistically significant. This study documents that low‐dose AF exposure was associated with greater child linear growth. Given its toxicity and carcinogenicity, our results do not change the urgent need to drastically reduce human AF exposure. Our findings show that the association between AF exposure and linear growth is more complex than previously thought.en
dcterms.accessRightsLimited Access
dcterms.bibliographicCitationLeroy, Jef L.; Sununtnasuk , Celeste; Garcia-Guerra, Armando and Wang, Jia-Sheng. 2018. Low level aflatoxin exposure associated with greater linear growth in southern Mexico: A longitudinal study. Maternal and Child Nutrition 14(4): e12619. https://doi.org/10.1111/mcn.12619en
dcterms.issued2018-05-31
dcterms.languageen
dcterms.licenseCopyrighted; all rights reserved
dcterms.publisherWiley-Blackwellen
dcterms.replaceshttps://ebrary.ifpri.org/digital/collection/p15738coll5/id/6252en
dcterms.subjectmycotoxinsen
dcterms.subjecthealthen
dcterms.subjectfood safetyen
dcterms.subjectaflatoxinsen
dcterms.subjectchild growthen
dcterms.typeJournal Article

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