Differential infection patterns and recent evolutionary origins of equine hepaciviruses in donkeys

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cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationCenter for Experimental and Clinical Infection Research, Hannoveren
cg.contributor.affiliationUniversity of Bonnen
cg.contributor.affiliationGerman Centre for Infection Researchen
cg.contributor.affiliationUniversity of Leuvenen
cg.contributor.affiliationMexican Social Security Instituteen
cg.contributor.affiliationDozulé Laboratory for Equine Diseases - Ansesen
cg.contributor.affiliationJustus Liebig University Giessenen
cg.contributor.affiliationKoret School of Veterinary Medicineen
cg.contributor.affiliationIstituto Zooprofilattico Sperimentale Lazio e Toscanaen
cg.contributor.affiliationUniversity of Naplesen
cg.contributor.affiliationTrakia Universityen
cg.contributor.affiliationUniversidad de Córdobaen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationUniversity of Bernen
cg.contributor.affiliationUniversità degli Studi di Teramoen
cg.contributor.affiliationUniversità degli Studi di Milanoen
cg.contributor.affiliationUniversity of Veterinary Medicine, Hannoveren
cg.contributor.crpAgriculture for Nutrition and Health
cg.contributor.donorDeutscher Akademischer Austauschdiensten
cg.contributor.donorDeutsche Forschungsgemeinschaften
cg.creator.identifierJoerg Jores: 0000-0003-3790-5746
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1128/jvi.01711-16en
cg.isijournalISI Journalen
cg.issn0022-538Xen
cg.issue1en
cg.journalJournal of Virologyen
cg.reviewStatusPeer Reviewen
cg.subject.ilriANIMAL DISEASESen
cg.volume91en
dc.contributor.authorWalter, S.en
dc.contributor.authorRasche, A.en
dc.contributor.authorMoreira-Soto, A.en
dc.contributor.authorPfaender, S.en
dc.contributor.authorBletsa, M.en
dc.contributor.authorCorman, V.M.en
dc.contributor.authorAguilar-Setien, A.en
dc.contributor.authorGarcía Lacy, F.en
dc.contributor.authorHans, A.en
dc.contributor.authorTodt, D.en
dc.contributor.authorSchuler, G.en
dc.contributor.authorShnaiderman-Torban, A.en
dc.contributor.authorSteinman, A.en
dc.contributor.authorRoncoroni, C.en
dc.contributor.authorVenezian, V.en
dc.contributor.authorRusenova, N.en
dc.contributor.authorSandev, N.en
dc.contributor.authorRusenov, A.en
dc.contributor.authorZapryanova, D.en
dc.contributor.authorGarcía Bocanegra, I.en
dc.contributor.authorJores, Joergen
dc.contributor.authorCarluccio, A.en
dc.contributor.authorVeronesi, M.C.en
dc.contributor.authorCavalleri, J.M.V.en
dc.contributor.authorDrosten, C.en
dc.contributor.authorLemey, P.en
dc.contributor.authorSteinmann, E.en
dc.contributor.authorDrexler, J.F.en
dc.date.accessioned2016-11-10T15:05:49Zen
dc.date.available2016-11-10T15:05:49Zen
dc.identifier.urihttps://hdl.handle.net/10568/77699
dc.titleDifferential infection patterns and recent evolutionary origins of equine hepaciviruses in donkeysen
dcterms.abstractThe hepatitis C virus (HCV) is a major human pathogen. Genetically related viruses in animals suggest a zoonotic origin of HCV. The closest relative of HCV is found in horses (termed equine hepacivirus, EqHV). However, low EqHV genetic diversity implies relatively recent acquisition of EqHV by horses, making a derivation of HCV from EqHV unlikely. To unravel the EqHV evolutionary history within equid sister species, we analyzed 829 donkeys and 53 mules sampled in nine European, Asian, African and American countries by molecular and serologic tools for EqHV infection. Antibodies were found in 278 animals (31.5%), and viral RNA was found in 3 animals (0.3%), all of which were simultaneously seropositive. A low RNA prevalence in spite of high seroprevalence suggests predominance of acute infection, a possible difference from the mostly chronic hepacivirus infection pattern seen in horses and humans. Limitation of transmission due to short courses of infection may explain the existence of entirely seronegative groups of animals. Donkey and horse EqHV strains were paraphyletic and 97.5-98.2% identical in their translated polyprotein sequences, making virus/host co-speciation unlikely. Evolutionary reconstructions supported host switches of EqHV between horses and donkeys without the involvement of adaptive evolution. Global admixture of donkey and horse hepaciviruses was compatible with anthropogenic alterations of EqHV ecology. In summary, our findings do not support EqHV as the origin of the significantly more diversified HCV. Identification of a host system with predominantly acute hepacivirus infection may enable new insights into the chronic infection pattern associated with HCV.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.bibliographicCitationWalter, S., Rasche, A., Moreira-Soto, A., Pfaender, S., Bletsa, M., Corman, V.M., Aguilar-Setien, A., García-Lacy, F., Hans, A., Todt, D., Schuler, G., Shnaiderman-Torban, A., Steinman, A., Roncoroni, C., Veneziano, V., Rusenova, N., Sandev, N., Rusenov, A., Zapryanova, D., García-Bocanegra, I., Jores, J., Carluccio, A., Veronesi, M.C., Cavalleri, J.M.V., Drosten, C., Lemey, P., Steinmann, E. and Drexler, J.F. 2017. Differential infection patterns and recent evolutionary origins of equine hepaciviruses in donkeys. Journal of Virology 91(1):e01711-16.en
dcterms.extentp. 01711-16en
dcterms.issued2017-01
dcterms.languageen
dcterms.licenseCopyrighted; all rights reserved
dcterms.publisherAmerican Society for Microbiologyen
dcterms.subjectanimal diseasesen
dcterms.typeJournal Article

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