A survey of mosquito-borne and insect-specific viruses in hospitals and livestock markets in western Kenya

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationInternational Centre of Insect Physiology and Ecologyen_US
cg.contributor.affiliationUniversity of Pretoriaen_US
cg.contributor.affiliationUniversity of Liverpoolen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.crpAgriculture for Nutrition and Healthen_US
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen_US
cg.contributor.donorGovernment of the United Kingdomen_US
cg.contributor.donorEconomic and Social Research Council, United Kingdomen_US
cg.contributor.donorMedical Research Council, United Kingdomen_US
cg.contributor.donorNatural Environment Research Council, United Kingdomen_US
cg.contributor.donorDefence Science and Technology Laboratory, United Kingdomen_US
cg.contributor.donorEuropean Unionen_US
cg.contributor.donorUK Research and Innovationen_US
cg.contributor.donorSwedish International Development Cooperation Agencyen_US
cg.contributor.donorSwiss Agency for Development and Cooperationen_US
cg.contributor.donorGovernment of Ethiopiaen_US
cg.contributor.donorGovernment of Kenyaen_US
cg.contributor.donorDeutscher Akademischer Austauschdiensten_US
cg.coverage.countryKenyaen_US
cg.coverage.iso3166-alpha2KEen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierLaura Cristina Falzon: 0000-0002-4043-1644en_US
cg.creator.identifierDaniel Masiga: 0000-0001-7513-0887en_US
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1371/journal.pone.0252369en_US
cg.isijournalISI Journalen_US
cg.issn1932-6203en_US
cg.issue5en_US
cg.journalPLOS ONEen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.ilriHUMAN HEALTHen_US
cg.subject.ilriLIVESTOCKen_US
cg.subject.impactAreaNutrition, health and food securityen_US
cg.subject.sdgSDG 3 - Good health and well-beingen_US
cg.volume16en_US
dc.contributor.authorChiuya, T.en_US
dc.contributor.authorMasiga, D.K.en_US
dc.contributor.authorFalzon, Laura C.en_US
dc.contributor.authorBastos, A.D.S.en_US
dc.contributor.authorFèvre, Eric M.en_US
dc.contributor.authorVillinger, J.en_US
dc.date.accessioned2021-06-07T13:45:53Zen_US
dc.date.available2021-06-07T13:45:53Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/113876en_US
dc.titleA survey of mosquito-borne and insect-specific viruses in hospitals and livestock markets in western Kenyaen_US
dcterms.abstractAedes aegypti and Culex pipiens complex mosquitoes are prolific vectors of arboviruses that are a global threat to human and animal health. Increased globalization and ease of travel have facilitated the worldwide dissemination of these mosquitoes and the viruses they transmit. To assess disease risk, we determined the frequency of arboviruses in western Kenyan counties bordering an area of high arboviral activity. In addition to pathogenic viruses, insect-specific flaviviruses (ISFs), some of which are thought to impair the transmission of specific pathogenic arboviruses, were also evaluated. We trapped mosquitoes in the short and long rainy seasons in 2018 and 2019 at livestock markets and hospitals. Mosquitoes were screened for dengue, chikungunya and other human pathogenic arboviruses, ISFs, and their blood-meal sources as determined by high-resolution melting analysis of (RT-)PCR products. Of 6,848 mosquitoes collected, 89% were trapped during the long rainy season, with A. aegypti (59%) and Cx. pipiens sensu lato (40%) being the most abundant. Most blood-fed mosquitoes were Cx. pipiens s.l. with blood-meals from humans, chicken, and sparrow (Passer sp.). We did not detect dengue or chikungunya viruses. However, one Culex poicilipes female was positive for Sindbis virus, 30 pools of Ae. aegypti had cell fusing agent virus (CFAV; infection rate (IR) = 1.27%, 95% CI = 0.87%-1.78%); 11 pools of Ae. aegypti had Aedes flavivirus (AeFV; IR = 0.43%, 95% CI = 0.23%-0.74%); and seven pools of Cx. pipiens s.l. (IR = 0.23%, 95% CI = 0.1%-0.45%) and one pool of Culex annulioris had Culex flavivirus. Sindbis virus, which causes febrile illness in humans, can complicate the diagnosis and prognosis of patients with fever. The presence of Sindbis virus in a single mosquito from a population of mosquitoes with ISFs calls for further investigation into the role ISFs may play in blocking transmission of other arboviruses in this region.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceScientistsen_US
dcterms.audienceAcademicsen_US
dcterms.available2021-05-28en_US
dcterms.bibliographicCitationChiuya, T., Masiga, D.K., Falzon, L.C., Bastos, A.D.S., Fèvre, E.M. and Villinger, J. 2021. A survey of mosquito-borne and insect-specific viruses in hospitals and livestock markets in western Kenya. PLOS ONE 16(5): e0252369.en_US
dcterms.extente0252369en_US
dcterms.issued2021-05-28en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherPublic Library of Scienceen_US
dcterms.subjectvirusesen_US
dcterms.subjectarbovirusesen_US
dcterms.subjectlivestocken_US
dcterms.subjecthealthen_US
dcterms.typeJournal Articleen_US

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