Quantifying the transmission of antimicrobial resistance at the human and livestock interface with genomics

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cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationUniversity of Edinburghen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.crpAgriculture for Nutrition and Health
cg.contributor.donorJoint Programming Initiative on Antimicrobial Resistanceen
cg.contributor.donorDarwin Trust of Edinburghen
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen
cg.contributor.donorEconomic and Social Research Council, United Kingdomen
cg.contributor.donorNatural Environment Research Council, United Kingdomen
cg.contributor.donorNovo Nordisk Foundationen
cg.creator.identifierDishon Muloi: 0000-0002-6236-2280en
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1016/j.cmi.2020.09.019en
cg.isijournalISI Journalen
cg.issn1198-743Xen
cg.issue12en
cg.journalClinical Microbiology and Infectionen
cg.reviewStatusPeer Reviewen
cg.subject.ilriAGRI-HEALTHen
cg.subject.ilriAMRen
cg.subject.ilriGENETICSen
cg.subject.ilriHUMAN HEALTHen
cg.subject.ilriLIVESTOCKen
cg.volume26en
dc.contributor.authorWee, B.A.en
dc.contributor.authorMuloi, D.M.en
dc.contributor.authorBunnik, B.A.D. vanen
dc.date.accessioned2020-11-12T13:53:39Zen
dc.date.available2020-11-12T13:53:39Zen
dc.identifier.urihttps://hdl.handle.net/10568/110142
dc.titleQuantifying the transmission of antimicrobial resistance at the human and livestock interface with genomicsen
dcterms.abstractBackground Livestock have been implicated as a reservoir for antimicrobial resistance (AMR) that can spread to humans. Close proximity and ecological interfaces involving livestock have been posited as risk factors for the transmission of AMR. In spite of this, there are sparse data and limited agreement on the transmission dynamics that occur. Objectives To identify how genome sequencing approaches can be used to quantify the dynamics of AMR transmission at the human–livestock interface, and where current knowledge can be improved to better understand the impact of transmission on the spread of AMR. Sources Key articles investigating various aspects of AMR transmission at the human–livestock interface are discussed, with a focus on Escherichia coli. Content We recapitulate the current understanding of the transmission of AMR between humans and livestock based on current genomic and epidemiological approaches. We discuss how the use of well-designed, high-resolution genome sequencing studies can improve our understanding of the human–livestock interface. Implications A better understanding of the human–livestock interface will aid in the development of evidence-based and effective One Health interventions that can ultimately reduce the burden of AMR in humans.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.bibliographicCitationWee, B.A., Muloi, D.M. and Bunnik, B.A.D. van. 2020. Quantifying the transmission of antimicrobial resistance at the human and livestock interface with genomics. Clinical Microbiology and Infection 26(12): 1612–1616.en
dcterms.extentp. 1612-1616en
dcterms.issued2020-12en
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherElsevieren
dcterms.subjectantimicrobial resistanceen
dcterms.subjectlivestocken
dcterms.subjecthealthen
dcterms.subjecthumansen
dcterms.subjectgenomicsen
dcterms.typeJournal Article

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