Global foot-and-mouth disease research update and gap analysis: 3 – Vaccines

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cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationInsight Editing Londonen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationPirbright Instituteen
cg.contributor.affiliationPlum Island Animal Disease Centeren
cg.contributor.affiliationEuropean Commission for the Control of Foot-and-Mouth Diseaseen
cg.contributor.affiliationAustralian Animal Health Laboratoryen
cg.contributor.affiliationUnited States Department of Agricultureen
cg.contributor.crpAgriculture for Nutrition and Health
cg.contributor.donorEuropean Unionen
cg.creator.identifierTheo Knight-Jones: 0000-0003-4342-6055
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1111/tbed.12521en
cg.isijournalISI Journalen
cg.issn1865-1674en
cg.journalTransboundary and Emerging Diseasesen
cg.reviewStatusPeer Reviewen
cg.subject.ilriANIMAL DISEASESen
cg.subject.ilriFMDen
cg.subject.ilriRESEARCHen
cg.subject.ilriVACCINESen
cg.volume63en
dc.contributor.authorRobinson, L.en
dc.contributor.authorKnight-Jones, Theodore J.D.en
dc.contributor.authorCharleston, B.en
dc.contributor.authorRodríguez, L.L.en
dc.contributor.authorGay, C.G.en
dc.contributor.authorSumption, Keith J.en
dc.contributor.authorVosloo, W.en
dc.date.accessioned2016-07-13T04:28:00Zen
dc.date.available2016-07-13T04:28:00Zen
dc.identifier.urihttps://hdl.handle.net/10568/76166
dc.titleGlobal foot-and-mouth disease research update and gap analysis: 3 – Vaccinesen
dcterms.abstractThis study assessed research knowledge gaps in the field of FMDV (foot-and-mouth disease virus) vaccines. The study took the form of a literature review (2011–15) combined with research updates collected in 2014 from 33 institutes from across the world. Findings were used to identify priority areas for future FMD vaccine research. Vaccines play a vital role in FMD control, used both to limit the spread of the virus during epidemics in FMD-free countries and as the mainstay of disease management in endemic regions, particularly where sanitary controls are difficult to apply. Improvements in the performance or cost-effectiveness of FMD vaccines will allow more widespread and efficient disease control. FMD vaccines have changed little in recent decades, typically produced by inactivation of whole virus, the quantity and stability of the intact viral capsids in the final preparation being key for immunogenicity. However, these are exciting times and several promising novel FMD vaccine candidates have recently been developed. This includes the first FMD vaccine licensed for manufacture and use in the USA; this adenovirus-vectored FMD vaccine causes in vivo expression of viral capsids in vaccinated animals. Another promising vaccine candidate comprises stabilized empty FMDV capsids produced in vitro in a baculovirus expression system. Recombinant technologies are also being developed to improve otherwise conventionally produced inactivated vaccines, for example, by creating a chimeric vaccine virus to increase capsid stability and by inserting sequences into the vaccine virus for desired antigen expression. Other important areas of ongoing research include enhanced adjuvants, vaccine quality control procedures and predicting vaccine protection from immune correlates, thus reducing dependency on animal challenge studies. Globally, the degree of independent vaccine evaluation is highly variable, and this is essential for vaccine quality. Previously neglected, the importance of evaluating vaccination programme effectiveness and impact is increasingly being recognized.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.available2016-06-20
dcterms.bibliographicCitationRobinson, L., Knight-Jones, T.J.D., Charleston, B., Rodriguez, L.L., Gay, C.G., Sumption, K.J. and Vosloo, W. 2016. Global foot-and-mouth disease research update and gap analysis: 3 – Vaccines. Transboundary and Emerging Diseases 63(Suppl. 1): 30–41.en
dcterms.extentp. 30-41en
dcterms.issued2016-06
dcterms.languageen
dcterms.licenseCopyrighted; all rights reserved
dcterms.publisherHindawi Limiteden
dcterms.subjectanimal diseasesen
dcterms.typeJournal Article

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