A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology

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cg.creator.identifierRoger Pelle: 0000-0003-1053-085X
cg.creator.identifierTushaar Shah: 0000-0002-0565-8464
cg.creator.identifierRichard Bishop: 0000-0002-3720-9970
cg.creator.identifierVishvanath Nene: 0000-0001-7066-4169
cg.creator.identifierEtienne de Villiers: 0000-0001-9878-1009
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1186/1745-7580-3-2en
cg.issn1745-7580en
cg.issue1en
cg.journalImmunome Researchen
cg.subject.ilriANIMAL DISEASESen
cg.subject.ilriVACCINESen
cg.subject.ilriGENETICSen
cg.subject.ilriDISEASE CONTROLen
cg.volume3en
dc.contributor.authorGraham, S.P.en
dc.contributor.authorHonda, Y.en
dc.contributor.authorPelle, Rogeren
dc.contributor.authorMwangi, David Mianoen
dc.contributor.authorGlew, E.J.en
dc.contributor.authorVilliers, Etienne P. deen
dc.contributor.authorShah, Tushaaren
dc.contributor.authorBishop, Richard P.en
dc.contributor.authorBruggen, P. van deren
dc.contributor.authorNene, Vishvanath M.en
dc.contributor.authorTaracha, E.L.N.en
dc.date.accessioned2010-05-06T09:07:49Zen
dc.date.available2010-05-06T09:07:49Zen
dc.identifier.urihttps://hdl.handle.net/10568/1394
dc.titleA novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinologyen
dcterms.abstractImmunity against the bovine protozoan parasite Theileria parva has previously been shown to be mediated through lysis of parasite-infected cells by MHC class I restricted CD8+ cytotoxic T lymphocytes. It is hypothesized that identification of CTL target schizont antigens will aid the development of a sub-unit vaccine. We exploited the availability of the complete genome sequence data and bioinformatics tools to identify genes encoding secreted or membrane anchored proteins that may be processed and presented by the MHC class I molecules of infected cells to CTL.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.bibliographicCitationGraham, S.P.; Honda, Y.; Pelle, R. et al. 2007. A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology. Immunome Research 3:2.en
dcterms.issued2007
dcterms.languageen
dcterms.publisherSpringeren
dcterms.subjectanimal diseasesen
dcterms.subjectdisease controlen
dcterms.typeJournal Article

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