Seroprevalence of brucellosis and risk factors associated with its seropositivity in cattle, goats and humans in Iganga District, Uganda

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationMakerere Universityen
cg.contributor.affiliationMinistry of Health, Ugandaen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationVétérinaires Sans Frontièresen
cg.contributor.affiliationMinistry of Agriculture, Ugandaen
cg.contributor.affiliationUniversity of Californiaen
cg.coverage.countryUganda
cg.coverage.iso3166-alpha2UG
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierMichel Dione: 0000-0001-7812-5776
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.11604/pamj.2019.33.99.16960en
cg.isijournalISI Journalen
cg.issn1937-8688en
cg.journalPan African Medical Journalen
cg.reviewStatusPeer Reviewen
cg.subject.ilriANIMAL DISEASESen
cg.subject.ilriANIMAL HEALTHen
cg.subject.ilriBRUCELLOSISen
cg.subject.ilriCATTLEen
cg.subject.ilriGOATSen
cg.subject.ilriLIVESTOCKen
cg.subject.ilriRESEARCHen
cg.volume33en
dc.contributor.authorNguna, J.en
dc.contributor.authorDione, Michel M.en
dc.contributor.authorApamaku, M.en
dc.contributor.authorMajalija, S.en
dc.contributor.authorMugizi, R.D.en
dc.contributor.authorOdoch, T.en
dc.contributor.authorKato, C.D.en
dc.contributor.authorTumwine, G.en
dc.contributor.authorKabaasa, J.D.en
dc.contributor.authorCurtis, K.en
dc.contributor.authorGraham, M.en
dc.contributor.authorEjobi, F.en
dc.contributor.authorGraham, T.en
dc.date.accessioned2019-12-13T15:19:00Zen
dc.date.available2019-12-13T15:19:00Zen
dc.identifier.urihttps://hdl.handle.net/10568/106140
dc.titleSeroprevalence of brucellosis and risk factors associated with its seropositivity in cattle, goats and humans in Iganga District, Ugandaen
dcterms.abstractIntroduction: the burden of brucellosis among smallholder farmers is poorly-documented in Uganda. The disease burden is likely to be high, given the high levels of endemicity, lots of exposures and due to lack of control measures. In order to designate appropriate control measures, the magnitude and risk factors for brucellosis need to be known. We established the burden of and risk factors for Brucella seropositivity in cattle, goats, and humans in Iganga district, eastern Uganda. Methods: a cross-sectional study was conducted in in Kigulamo Parish, Iganga District. We enrolled 226 households and administered a structured questionnaire to heads of households to capture data on socio-demographic characteristics, human brucellosis-related risk factors, and livestock farming practices. Human, cattle, and goat blood samples were collected and tested serologically using commercial indirect-ELISA kits manufactured by USDA, USA. Results: of 451 human blood samples, 20 (4.4%) were positive. Among 345 cattle blood samples, 4 (1.2%) were positive and among 351 goat blood samples, one (0.3%) was positive. Persons who reported consuming locally-made dairy products had 4 times higher odds of Brucella seropositivity (OR = 4.0, CI = 1.14-14.03, p = 0.031) than those who did not. None of the risk factors we asked about were significantly associated with seropositivity in cattle and goats. Conclusion: the seroprevalence of brucellosis in humans in smallholder households in Kigulamo was relatively low and associated with consumption of locally made dairy products. No risk factors were significantly associated with seropositivity in livestock, likely due to the small number of seropositive animals. We recommend a One Health approach to control brucellosis simultaneously in animals and humans needed to sustainably reduce the burden of brucellosis in Uganda and beyond.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.available2019
dcterms.bibliographicCitationNguna, J., Dione, M., Apamaku, M., Majalija, S., Mugizi, R.D., Odoch, T., Kato, C.D., Tumwine, G., Kabaasa, J.D., Curtis, K., Graham, M., Ejobi, F. and Graham, T. 2019. Seroprevalence of brucellosis and risk factors associated with its seropositivity in cattle, goats and humans in Iganga District, Uganda. Pan African Medical Journal 33: 99.en
dcterms.issued2019
dcterms.languageen
dcterms.licenseCC-BY-2.0
dcterms.publisherPan African Medical Journalen
dcterms.subjectanimal diseasesen
dcterms.subjectbrucellosisen
dcterms.subjectrisk factorsen
dcterms.subjectcattleen
dcterms.subjectgoatsen
dcterms.subjectmankinden
dcterms.subjecthealthen
dcterms.subjectresearchen
dcterms.subjectlivestocken
dcterms.typeJournal Article

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