Antimicrobial use and antimicrobial resistance in Escherichia coli in semi-intensive and free-range poultry farms in Uganda

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationFederal Institute for Risk Assessment, Germanyen_US
cg.contributor.affiliationMakerere Universityen_US
cg.contributor.affiliationInstitute of Virology and Immunology, Switzerlanden_US
cg.contributor.affiliationUniversity of Bernen_US
cg.contributor.affiliationUniversity of Copenhagenen_US
cg.contributor.affiliationNational Agricultural Research Organization, Ugandaen_US
cg.contributor.affiliationUniversity of Liverpoolen_US
cg.contributor.crpAgriculture for Nutrition and Healthen_US
cg.contributor.crpLivestocken_US
cg.contributor.donorFederal Ministry for Economic Cooperation and Development, Germanyen_US
cg.coverage.countryUgandaen_US
cg.coverage.iso3166-alpha2UGen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierDICKSON NDOBOLI: 0000-0003-4764-5861en_US
cg.creator.identifierDishon Muloi: 0000-0002-6236-2280en_US
cg.creator.identifierKristina Roesel: 0000-0002-2553-1129en_US
cg.creator.identifierMichel Dione: 0000-0001-7812-5776en_US
cg.creator.identifierArshnee Moodley: 0000-0002-6469-3948en_US
cg.creator.identifierBarbara Wieland: 0000-0003-4020-9186en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1016/j.onehlt.2024.100762en_US
cg.isijournalISI Journalen_US
cg.issn2352-7714en_US
cg.journalOne Healthen_US
cg.reviewStatusPeer Reviewen_US
cg.speciesEscherichia colien_US
cg.subject.actionAreaResilient Agrifood Systemsen_US
cg.subject.ilriAMRen_US
cg.subject.ilriPOULTRYen_US
cg.subject.impactAreaNutrition, health and food securityen_US
cg.subject.impactPlatformNutrition, Health and Food Securityen_US
cg.subject.sdgSDG 3 - Good health and well-beingen_US
cg.volume18en_US
dc.contributor.authorMbatidde, Ireneen_US
dc.contributor.authorNdoboli, Dicksonen_US
dc.contributor.authorAyebare, Drecken_US
dc.contributor.authorMuloi, Dishonen_US
dc.contributor.authorRoesel, Kristinaen_US
dc.contributor.authorOchieng, Linneten_US
dc.contributor.authorDione, Michel M.en_US
dc.contributor.authorTenhagen, B.-A.en_US
dc.contributor.authorBiryomumaisho, S.en_US
dc.contributor.authorWampande, E.en_US
dc.contributor.authorWieland, Barbaraen_US
dc.contributor.authorOlsen, J.E.en_US
dc.contributor.authorMoodley, Arshneeen_US
dc.date.accessioned2024-05-24T12:09:52Zen_US
dc.date.available2024-05-24T12:09:52Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/144045en_US
dc.titleAntimicrobial use and antimicrobial resistance in Escherichia coli in semi-intensive and free-range poultry farms in Ugandaen_US
dcterms.abstractLivestock associated antimicrobial resistance (AMR) can reduce productivity and cause economic losses, threatening the livelihoods of poor farming communities in low-income settings. We investigated the practices and risk factors for increased antibiotic use, and AMR in <i>Escherichia coli</i> including resistance to human critically important antibiotics like cefotaxime and colistin in semi-intensive and free-range poultry farms in Uganda. Samples and farm management data were collected from 402 poultry farms in two districts between October 2021 to March 2022. Samples were processed to isolate <i>E. coli</i> and to quantify cefotaxime (CTX) and colistin (COL) resistant coliforms. The identification of presumptive <i>E. coli</i> isolated on MacConkey agar without antibiotics, was confirmed by matrix-assisted laser desorption/ionization-time of flight mass spectrometry and subjected to antimicrobial susceptibility testing by disk diffusion using EUCAST guidelines. Our models indicated that antibiotic use was associated with production intensity, and type of feed used. Moreover, semi-intensive farmers had better knowledge on antibiotic use compared to farmers in the free-range system. In semi-intensive farms, 52% harbored COL<sup>R</sup> and 57% CTX<sup>R</sup> coliforms. In free-range farms, 54% had COL<sup>R</sup> and 67% CTX<sup>R</sup> coliforms. Resistance to tetracycline, ampicillin and enrofloxacin were more frequent in semi-intensive farms compared to the free-range farms. Multi-drug resistant <i>E. coli</i> were identified in both poultry production systems despite different management and antibiotic use practices. There was no significant relationship between antibiotic use and resistance for the six antibiotics tested.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceAcademicsen_US
dcterms.audienceScientistsen_US
dcterms.available2024-05-23en_US
dcterms.bibliographicCitationMbatidde, I., Ndoboli, D., Ayebare, D., Muloi, D., Roesel, K., Ochieng, L., Dione, M., Tenhagen, B.-A., Biryomumaisho, S., Wampande, E., Wieland, B., Olsen, J.E. and Moodley, A. 2024. Antimicrobial use and antimicrobial resistance in <i>Escherichia coli</i> in semi-intensive and free-range poultry farms in Uganda. <i>One Health</i> 18: 100762.en_US
dcterms.extent100762en_US
dcterms.issued2024-06en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherElsevieren_US
dcterms.subjectantimicrobial resistanceen_US
dcterms.subjectpoultryen_US
dcterms.typeJournal Articleen_US

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