Deterministic processes structure bacterial genetic communities across an urban landscape

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationUniversity of Liverpoolen
cg.contributor.affiliationUniversity of Edinburghen
cg.contributor.affiliationUniversity of Oxforden
cg.contributor.affiliationUniversity of Southamptonen
cg.contributor.affiliationFood and Agriculture Organization of the United Nationsen
cg.contributor.affiliationNational Museums of Kenyaen
cg.contributor.affiliationKenya Medical Research Instituteen
cg.contributor.affiliationUniversity of Nairobien
cg.contributor.crpAgriculture for Nutrition and Health
cg.contributor.donorWellcome Trusten
cg.contributor.donorMedical Research Council, United Kingdomen
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen
cg.contributor.donorEconomic and Social Research Council, United Kingdomen
cg.contributor.donorNatural Environment Research Council, United Kingdomen
cg.coverage.countryKenya
cg.coverage.iso3166-alpha2KE
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierJames Hassell: 0000-0002-4710-2827
cg.creator.identifierJudy Bettridge: 0000-0002-3917-4660
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986
cg.creator.identifierDishon Muloi: 0000-0002-6236-2280
cg.creator.identifierTimothy Robinson: 0000-0002-4266-963X
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1038/s41467-019-10595-1en
cg.isijournalISI Journalen
cg.issn2041-1723en
cg.issue1en
cg.journalNature Communicationsen
cg.reviewStatusPeer Reviewen
cg.subject.ilriAGRI-HEALTHen
cg.subject.ilriHEALTHen
cg.subject.ilriZOONOTIC DISEASESen
cg.volume10en
dc.contributor.authorHassell, James M.en
dc.contributor.authorWard, M.J.en
dc.contributor.authorMuloi, Dishon M.en
dc.contributor.authorBettridge, Judy M.en
dc.contributor.authorPhan, H.en
dc.contributor.authorRobinson, Timothy P.en
dc.contributor.authorOgendo, A.en
dc.contributor.authorImboma, Titusen
dc.contributor.authorKiiru, J.en
dc.contributor.authorKariuki, S.en
dc.contributor.authorBegon, M.en
dc.contributor.authorKang'ethe, Erastus K.en
dc.contributor.authorWoolhouse, Mark E.J.en
dc.contributor.authorFèvre, Eric M.en
dc.date.accessioned2019-06-19T09:10:40Zen
dc.date.available2019-06-19T09:10:40Zen
dc.identifier.urihttps://hdl.handle.net/10568/101612
dc.titleDeterministic processes structure bacterial genetic communities across an urban landscapeen
dcterms.abstractLand-use change is predicted to act as a driver of zoonotic disease emergence through human exposure to novel microbial diversity, but evidence for the effects of environmental change on microbial communities in vertebrates is lacking. We sample wild birds at 99 wildlife-livestock-human interfaces across Nairobi, Kenya, and use whole genome sequencing to characterise bacterial genes known to be carried on mobile genetic elements (MGEs) within avian-borne Escherichia coli (n = 241). By modelling the diversity of bacterial genes encoding virulence and antimicrobial resistance (AMR) against ecological and anthropogenic forms of urban environmental change, we demonstrate that communities of avian-borne bacterial genes are shaped by the assemblage of co-existing avian, livestock and human communities, and the habitat within which they exist. In showing that non-random processes structure bacterial genetic communities in urban wildlife, these findings suggest that it should be possible to forecast the effects of urban land-use change on microbial diversity.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.available2019-06-14
dcterms.bibliographicCitationHassell, J.M., Ward, M.J., Muloi, D., Bettridge, J.M., Phan, H., Robinson, T.P., Ogendo, A., Imboma, T., Kiiru, J., Kariuki, S., Begon, M., Kang'ethe, E.K., Woolhouse, M.E.J. and Fèvre, E.M. 2019. Deterministic processes structure bacterial genetic communities across an urban landscape. Nature Communications 10: 2643.en
dcterms.issued2019-06-14
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherSpringeren
dcterms.subjectzoonosesen
dcterms.subjectland useen
dcterms.subjecthealthen
dcterms.subjectantimicrobial resistanceen
dcterms.typeJournal Article

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