Cross-sectional serosurvey of Leptospira species among slaughter pigs, goats, and sheep in Uganda

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationUniversity of Bernen_US
cg.contributor.affiliationMakerere Universityen_US
cg.contributor.affiliationNational Livestock Resources Research Institute, Ugandaen_US
cg.contributor.affiliationFederal Institute for Risk Assessment, Germanyen_US
cg.contributor.affiliationMinistry of Agriculture, Animal Industry and Fisheries, Ugandaen_US
cg.contributor.crpAgriculture for Nutrition and Healthen_US
cg.contributor.crpLivestocken_US
cg.contributor.donorFederal Ministry for Economic Cooperation and Development, Germanyen_US
cg.contributor.donorCGIAR Trust Funden_US
cg.contributor.initiativeOne Healthen_US
cg.coverage.countryUgandaen_US
cg.coverage.iso3166-alpha2UGen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierLordrick Alinaitwe: 0000-0002-5432-6407en_US
cg.creator.identifierVelma Kivali: 0000-0003-0797-4484en_US
cg.creator.identifierJames Bugeza: 0000-0002-8124-2807en_US
cg.creator.identifierKristina Roesel: 0000-0002-2553-1129en_US
cg.creator.identifierElizabeth Cook: 0000-0001-6081-8363en_US
cg.creator.identifierMartin Wainaina: 0000-0002-4938-2543en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.dataurlhttps://hdl.handle.net/20.500.11766.1/FK2/BGBMSPen_US
cg.identifier.doihttps://doi.org/10.1371/journal.pntd.0012055en_US
cg.isijournalISI Journalen_US
cg.issn1935-2735en_US
cg.issue3en_US
cg.journalPLOS Neglected Tropical Diseasesen_US
cg.reviewStatusPeer Reviewen_US
cg.speciesLeptospira spp.en_US
cg.subject.actionAreaResilient Agrifood Systemsen_US
cg.subject.ilriANIMAL DISEASESen_US
cg.subject.ilriGOATSen_US
cg.subject.ilriPIGSen_US
cg.subject.ilriSHEEPen_US
cg.subject.ilriSMALL RUMINANTSen_US
cg.subject.ilriZOONOTIC DISEASESen_US
cg.subject.impactAreaNutrition, health and food securityen_US
cg.subject.impactPlatformNutrition, Health and Food Securityen_US
cg.subject.sdgSDG 3 - Good health and well-beingen_US
cg.volume18en_US
dc.contributor.authorAlinaitwe, Lordricken_US
dc.contributor.authorAturinda, C.J.en_US
dc.contributor.authorLubega, A.en_US
dc.contributor.authorKivali, Velmaen_US
dc.contributor.authorBugeza, Jamesen_US
dc.contributor.authorWainaina, M.en_US
dc.contributor.authorRichter, M.H.en_US
dc.contributor.authorHoona, J.J.en_US
dc.contributor.authorRoesel, Kristinaen_US
dc.contributor.authorMayer-Scholl, A.en_US
dc.contributor.authorCook, Elizabeth A.J.en_US
dc.contributor.authorKankya, C.en_US
dc.contributor.authorDürr, S.en_US
dc.date.accessioned2024-03-21T08:55:16Zen_US
dc.date.available2024-03-21T08:55:16Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/140535en_US
dc.titleCross-sectional serosurvey of Leptospira species among slaughter pigs, goats, and sheep in Ugandaen_US
dcterms.abstract<b>Introduction</b> <i>Leptospira</i> are a group of bacteria, including pathogenic types that cause leptospirosis. In Uganda, <i>Leptospira</i> exposure has been reported in humans, with domesticated animals being speculated as the source. However, comparable evidence of <i>Leptospira</i> prevalence and circulating serovars/serogroups in animals is only documented for cattle, and dogs. Our study determined <i>Leptospira</i> seroprevalence, associated risk factors and serogroups circulating among slaughtered pigs, goats, and sheep in Uganda. <b>Methods</b> During an 11-month cross-sectional survey in selected slaughter facilities in three regions of Uganda, we collected blood from 926 pigs, 347 goats, and 116 sheep. The age, sex, breed, and origin of each sampled animal were noted. The samples were tested for anti-<i>Leptospira</i> antibodies using the microscopic agglutination test, based on a panel of 12 serovars belonging to 12 serogroups. <b>Results</b> <i>Leptospira</i> seroprevalence was 26.67% (247/926, 95%CI 23.92–29.61) among pigs, and 21.81% (101/463, 95%CI 18.29–25.80) in goats and sheep (small ruminants). <i>L. interrogans</i> Australis and <i>L. kirschneri</i> Grippotyphosa were the commonest serovars among pigs, as was <i>L. borgpetersenii</i>Tarassovi in small ruminants. Pigs sourced from the Eastern (Odds Ratio [OR] = 2.82, 95%CI 1.84–4.30) and Northern (OR = 3.56, 95%CI 2.52–5.02) regions were more likely to be seropositive, compared to those from the Central region. For small ruminants, being female (OR 2.74, 95% CI 1.69–4.57) and adult (OR 4.47, 95% CI 1.57–18.80) was significantly more associated with <i>Leptospira</i> seropositivity. <b>Conclusion/significance</b> Detection of a moderate seroprevalence, and several <i>Leptospira</i> serogroups among pigs, sheep, and goats from all regions of Uganda, supports existing reports in cattle and dogs, and implies widespread <i>Leptospira</i> exposure in domestic animals in Uganda. These findings may inform future programs for the control of leptospirosis in livestock in Uganda.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceAcademicsen_US
dcterms.audienceScientistsen_US
dcterms.available2024-03-15en_US
dcterms.bibliographicCitationAlinaitwe, L., Aturinda, C.J., Lubega, A., Kivali, V., Bugeza, J., Wainaina, M., Richter, M.H., Hoona, J.J., Roesel, K., Mayer-Scholl, A., Cook, E.A.J., Kankya, C. and Dürr, S. 2024. Cross-sectional serosurvey of <i>Leptospira</i> species among slaughter pigs, goats, and sheep in Uganda. <i>PLOS Neglected Tropical Diseases</i> 18(3): e0012055.en_US
dcterms.extente0012055en_US
dcterms.issued2024-03-15en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherPublic Library of Scienceen_US
dcterms.subjectzoonosesen_US
dcterms.subjectswineen_US
dcterms.subjectgoatsen_US
dcterms.subjectsmall ruminantsen_US
dcterms.subjectsheepen_US
dcterms.subjectanimal diseasesen_US
dcterms.typeJournal Articleen_US

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