Seroprevalence and related risk factors of Brucella spp. in livestock and humans in Garbatula subcounty, Isiolo county, Kenya

Simple item page
cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationUniversity of Nairobien_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationZoonotic Disease Unit, Kenyaen_US
cg.contributor.affiliationFreie Universität Berlinen_US
cg.contributor.affiliationUniversity of Embuen_US
cg.contributor.affiliationCounty Government of Kilifien_US
cg.contributor.donorDefense Threat Reduction Agencyen_US
cg.contributor.donorCGIAR Trust Funden_US
cg.coverage.countryKenyaen_US
cg.coverage.iso3166-alpha2KEen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierAthman Mwatondo: 0000-0002-3180-7013en_US
cg.creator.identifierJames Akoko: 0000-0001-5730-4505en_US
cg.creator.identifierRichard Nyamota: 0000-0002-9569-1953en_US
cg.creator.identifierBernard Bett: 0000-0001-9376-2941en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1371/journal.pntd.0011682en_US
cg.isijournalISI Journalen_US
cg.issn1935-2735en_US
cg.issue10en_US
cg.journalPLOS Neglected Tropical Diseasesen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.actionAreaResilient Agrifood Systemsen_US
cg.subject.ilriANIMAL PRODUCTSen_US
cg.subject.ilriBRUCELLOSISen_US
cg.subject.ilriCAMELSen_US
cg.subject.ilriCATTLEen_US
cg.subject.ilriGOATSen_US
cg.subject.ilriLIVESTOCKen_US
cg.subject.ilriONE HEALTHen_US
cg.subject.ilriSHEEPen_US
cg.subject.ilriSMALL RUMINANTSen_US
cg.subject.ilriZOONOTIC DISEASESen_US
cg.subject.impactAreaNutrition, health and food securityen_US
cg.subject.impactPlatformNutrition, Health and Food Securityen_US
cg.subject.sdgSDG 3 - Good health and well-beingen_US
cg.volume17en_US
dc.contributor.authorMwatondo, Athmanen_US
dc.contributor.authorMuturi, Mathewen_US
dc.contributor.authorAkoko, James M.en_US
dc.contributor.authorNyamota, Richarden_US
dc.contributor.authorNthiwa, D.en_US
dc.contributor.authorMaina, J.en_US
dc.contributor.authorOmolo, J.en_US
dc.contributor.authorGichuhi, S.en_US
dc.contributor.authorMureithi, M.W.en_US
dc.contributor.authorBett, Bernard K.en_US
dc.date.accessioned2023-10-26T14:42:22Zen_US
dc.date.available2023-10-26T14:42:22Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/132487en_US
dc.titleSeroprevalence and related risk factors of Brucella spp. in livestock and humans in Garbatula subcounty, Isiolo county, Kenyaen_US
dcterms.abstractBackground Brucellosis is a neglected zoonotic disease that affects both animals and humans, causing debilitating illness in humans and socio-economic losses in livestock-keeping households globally. The disease is endemic in many developing countries, including Kenya, but measures to prevent and control the disease are often inadequate among high-risk populations. This study aimed to investigate the human and livestock seroprevalence of brucellosis and associated risk factors of Brucella spp. in a pastoralist region of northern Kenya. Methods A cross-sectional survey was conducted using a two-stage cluster sampling method to select households, livestock, and humans for sampling. Blood samples were collected from 683 humans and 2157 animals, and Brucella immunoglobulin G (IgG) antibodies were detected using enzyme-linked immunosorbent assays. A structured questionnaire was used to collect data on potential risk factors associated with human and animal exposures. Risk factors associated with Brucella spp. exposures in humans and livestock were identified using Multivariate logistic regression. Results The results indicated an overall livestock Brucella spp. seroprevalence of 10.4% (95% Confidence Interval (CI): 9.2–11.7). Camels had the highest exposure rates at 19.6% (95% CI: 12.4–27.3), followed by cattle at 13.2% (95% CI: 9.3–17.1), goats at 13.1% (95% CI: 11.1–15.3) and sheep at 5.4% (95% CI: 4.0–6.9). The herd-level seroprevalence was 51.7% (95% CI, 47.9–55.7). Adult animals (Adjusted Odds Ratio (aOR) = 2.3, CI = 1.3–4.0), female animals (aOR = 1.7, CI: 1.1–2.6), and large herd sizes (aOR = 2.3, CI = 1.3–4.0) were significantly associated with anti-brucella antibody detection while sheep had significantly lower odds of Brucella spp. exposure compared to cattle (aOR = 1.3, CI = 0.8–2.1) and camels (aOR = 2.4, CI = 1.2–4.8). Human individual and household seroprevalences were 54.0% (95 CI, 50.2–58.0) and 86.4% (84.0–89.0), respectively. Significant risk factors associated with human seropositivity included being male (aOR = 2.1, CI:1.3–3.2), residing in Sericho ward (aOR = 1.6, CI:1.1–2.5) and having no formal education (aOR = 3.0, CI:1.5–5.9). There was a strong correlation between human seropositivity and herd exposure (aOR = 1.6, CI:1.2–2.3). Conclusions The study provides evidence of high human and livestock exposures to Brucella spp. and identifies important risk factors associated with disease spread. These findings emphasize the need for targeted prevention and control measures to curb the spread of brucellosis and implement a One Health surveillance to ensure early detection of the disease in Isiolo County, Northern Kenya.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceAcademicsen_US
dcterms.audienceScientistsen_US
dcterms.available2023-10-16en_US
dcterms.bibliographicCitationMwatondo, A., Muturi, M., Akoko, J., Nyamota, R., Nthiwa, D., Maina, J., Omolo, J., Gichuhi, S., Mureithi, M.W. and Bett, B. 2023. Seroprevalence and related risk factors of Brucella spp. in livestock and humans in Garbatula subcounty, Isiolo county, Kenya. PLOS Neglected Tropical Diseases 17(10): e0011682.en_US
dcterms.extente0011682en_US
dcterms.issued2023-10-16en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherPublic Library of Scienceen_US
dcterms.subjectbrucellosisen_US
dcterms.subjectzoonosesen_US
dcterms.subjectlivestocken_US
dcterms.subjectcattleen_US
dcterms.subjectcamelsen_US
dcterms.subjectsheepen_US
dcterms.subjectgoatsen_US
dcterms.subjectsmall ruminantsen_US
dcterms.subjectanimal productsen_US
dcterms.subjectone health approachen_US
dcterms.typeJournal Articleen_US

Files

License bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ILRI articles in journals
Co-infection with Rift Valley fever virus, Brucella spp. and Coxiella burnetii in humans and animals in Kenya: Disease burden and ecological factors
ILRI animal and human health program outputs (2017-2024)