The advancements, challenges and future implications of the CRISPR/Cas9 system in swine research
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Zhang, J., Khazalwa, E.M., Abkallo, H.M., Zhou, Y., Nie, X., Ruan, J., Zhao, C., Wang, J., Xu, J., Li, X., Zhao, S., Zuo, E., Steinaa, L. and Xie, S. 2021. The advancements, challenges and future implications of the CRISPR/Cas9 system in swine research. Journal of Genetics and Genomics 48(5): 347–360.
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Clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9 (CRISPR/Cas9) genome editing technology has dramatically influenced swine research by enabling the production of high-quality disease-resistant pig breeds, thus improving yields. Additionally, CRISPR/Cas9 has been used extensively in pigs as one of the tools in biomedical research. In this review, we present the advancements of the CRISPR/Cas9 system in swine research such as animal breeding, vaccine development, xenotransplantation, and disease modelling. We also highlight the current challenges and some potential applications of the CRISPR/Cas9 technologies.
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Lucilla Steinaa https://orcid.org/0000-0003-3691-3971