The advancements, challenges and future implications of the CRISPR/Cas9 system in swine research

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cg.authorship.typesCGIAR and developing country instituteen
cg.contributor.affiliationHuazhong Agricultural Universityen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationAnhui Academy of Agriculture Science, Chinaen
cg.contributor.affiliationChinese Academy of Agricultural Sciencesen
cg.contributor.crpLivestock
cg.creator.identifierHussein Abkallo: 0000-0002-5594-4418
cg.creator.identifierLucilla Steinaa: 0000-0003-3691-3971
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1016/j.jgg.2021.03.015en
cg.isijournalISI Journalen
cg.issn1673-8527en
cg.issue5en
cg.journalJournal of Genetics and Genomicsen
cg.reviewStatusPeer Reviewen
cg.subject.ilriPIGSen
cg.subject.ilriRESEARCHen
cg.subject.impactAreaNutrition, health and food security
cg.subject.sdgSDG 2 - Zero hungeren
cg.volume48en
dc.contributor.authorZhang, J.en
dc.contributor.authorKhazalwa, Emmanuel M.en
dc.contributor.authorAbkallo, Hussein M.en
dc.contributor.authorZhou, Y.en
dc.contributor.authorNie, X.en
dc.contributor.authorRuan, J.en
dc.contributor.authorZhao, C.en
dc.contributor.authorWang, J.en
dc.contributor.authorXu, J.en
dc.contributor.authorLi, X.en
dc.contributor.authorZhao, S.en
dc.contributor.authorZuo, E.en
dc.contributor.authorSteinaa, Lucillaen
dc.contributor.authorXie, S.en
dc.date.accessioned2021-05-19T08:39:40Zen
dc.date.available2021-05-19T08:39:40Zen
dc.identifier.urihttps://hdl.handle.net/10568/113738
dc.titleThe advancements, challenges and future implications of the CRISPR/Cas9 system in swine researchen
dcterms.abstractClustered regularly interspaced short palindromic repeats/CRISPR associated protein 9 (CRISPR/Cas9) genome editing technology has dramatically influenced swine research by enabling the production of high-quality disease-resistant pig breeds, thus improving yields. Additionally, CRISPR/Cas9 has been used extensively in pigs as one of the tools in biomedical research. In this review, we present the advancements of the CRISPR/Cas9 system in swine research such as animal breeding, vaccine development, xenotransplantation, and disease modelling. We also highlight the current challenges and some potential applications of the CRISPR/Cas9 technologies.en
dcterms.accessRightsLimited Access
dcterms.audienceScientistsen
dcterms.audienceAcademicsen
dcterms.bibliographicCitationZhang, J., Khazalwa, E.M., Abkallo, H.M., Zhou, Y., Nie, X., Ruan, J., Zhao, C., Wang, J., Xu, J., Li, X., Zhao, S., Zuo, E., Steinaa, L. and Xie, S. 2021. The advancements, challenges and future implications of the CRISPR/Cas9 system in swine research. Journal of Genetics and Genomics 48(5): 347–360.en
dcterms.extentp. 347-360en
dcterms.issued2021-05
dcterms.languageen
dcterms.licenseCopyrighted; all rights reserved
dcterms.publisherElsevieren
dcterms.subjectswineen
dcterms.subjectresearchen
dcterms.subjectgenomicsen
dcterms.subjectcrispren
dcterms.typeJournal Article

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