Using a One Health case-based investigation for improved control of brucellosis in Isiolo, Kenya

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationUppsala Universityen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationMaseno Universityen_US
cg.contributor.affiliationSwedish University of Agricultural Sciencesen_US
cg.contributor.crpAgriculture for Nutrition and Healthen_US
cg.contributor.donorUnited States Defense Threat Reduction Agencyen_US
cg.contributor.donorSwedish International Development Cooperation Agencyen_US
cg.coverage.countryKenyaen_US
cg.coverage.iso3166-alpha2KEen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierJames Akoko: 0000-0001-5730-4505en_US
cg.creator.identifierBernard Bett: 0000-0001-9376-2941en_US
cg.creator.identifierJohanna Lindahl: 0000-0002-1175-0398en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.3389/fitd.2021.711425en_US
cg.issn2673-7515en_US
cg.journalFrontiers in Tropical Diseasesen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.ilriBRUCELLOSISen_US
cg.subject.ilriDISEASE CONTROLen_US
cg.subject.ilriHUMAN HEALTHen_US
cg.subject.ilriONE HEALTHen_US
cg.subject.impactAreaNutrition, health and food securityen_US
cg.subject.sdgSDG 3 - Good health and well-beingen_US
cg.volume2en_US
dc.contributor.authorKarlsson, P.A.en_US
dc.contributor.authorPersson, C.en_US
dc.contributor.authorAkoko, James M.en_US
dc.contributor.authorBett, Bernard K.en_US
dc.contributor.authorLundkvist, Å.en_US
dc.contributor.authorLindahl, Johanna F.en_US
dc.date.accessioned2021-09-22T09:07:41Zen_US
dc.date.available2021-09-22T09:07:41Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/115084en_US
dc.titleUsing a One Health case-based investigation for improved control of brucellosis in Isiolo, Kenyaen_US
dcterms.abstractBrucella is a highly pathogenic bacteria endemic in Kenya, and in spite of its severity in humans, the highly inadequate Febrile Antigen Brucella Agglutination Test (FBAT) remains a primary tool for its diagnosis. Blood samples were collected from febrile patients in Kinna health center and screened by the local routine. Milk samples were purchased from local milk hawkers and analyzed for Brucella antibodies using the milk ring test (MRT). The MRT-positive milk was traced to farms, and lactating cattle were sampled for milk and blood. Milk was MRT-tested and the serum was analyzed using the Rose Bengal test (RBT) and iELISA. Available patient and farm samples were stored on FTA cards for qPCR analyses. Despite a limited sample size, our study, in line with previous reports, shows a low diagnostic sensitivity (67%) and specificity (40%) of FBAT when compared to qPCR. As many as 48% of the raw bulk cattle milk samples were MRT-positive for Brucella antibodies and 60% of cattle on three visited farms were IS711 qPCR-positive. This case-based One Health investigation confirms the suspected Brucella presence, suggesting a targeted vaccination at high-prevalence farms, urgent interventions on milk safety, and a re-evaluation of the diagnostic and treatment regimen.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceScientistsen_US
dcterms.audienceAcademicsen_US
dcterms.available2021-09-21en_US
dcterms.bibliographicCitationKarlsson, P.A., Persson, C., Akoko, J., Bett, B., Lundkvist, Å. and Lindahl, J.F. 2021. Using a One Health case-based investigation for improved control of brucellosis in Isiolo, Kenya. Frontiers in Tropical Diseases 2: 711425.en_US
dcterms.extent711425en_US
dcterms.issued2021-09-21en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherFrontiers Mediaen_US
dcterms.subjectbrucellosisen_US
dcterms.subjectdisease controlen_US
dcterms.subjecthealthen_US
dcterms.typeJournal Articleen_US

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