Seroprevalence of Brucella spp. and Rift Valley fever virus among slaughterhouse workers in Isiolo County, northern Kenya

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationZoonotic Disease Unit, Kenyaen
cg.contributor.affiliationUniversity of Embuen
cg.contributor.affiliationFreie Universität Berlinen
cg.contributor.affiliationWorld Organisation for Animal Healthen
cg.contributor.affiliationLos Alamos National Laboratoryen
cg.contributor.donorDefense Threat Reduction Agencyen
cg.contributor.donorCGIAR Trust Funden
cg.coverage.countryKenya
cg.coverage.iso3166-alpha2KE
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierRichard Nyamota: 0000-0002-9569-1953
cg.creator.identifierJames Akoko: 0000-0001-5730-4505
cg.creator.identifierAthman Mwatondo: 0000-0002-3180-7013
cg.creator.identifierLillian Wambua: 0000-0003-3632-7411
cg.creator.identifierBernard Bett: 0000-0001-9376-2941
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1371/journal.pntd.0011677en
cg.isijournalISI Journalen
cg.issn1935-2735en
cg.issue10en
cg.journalPLOS Neglected Tropical Diseasesen
cg.reviewStatusPeer Reviewen
cg.subject.actionAreaResilient Agrifood Systems
cg.subject.ilriBRUCELLOSISen
cg.subject.ilriHUMAN HEALTHen
cg.subject.ilriRVFen
cg.subject.ilriZOONOTIC DISEASESen
cg.subject.impactAreaNutrition, health and food security
cg.subject.impactPlatformNutrition, Health and Food Security
cg.subject.sdgSDG 3 - Good health and well-beingen
cg.volume17en
dc.contributor.authorNyamota, Richarden
dc.contributor.authorMaina, J.en
dc.contributor.authorAkoko, James M.en
dc.contributor.authorNthiwa, D.en
dc.contributor.authorMwatondo, Athmanen
dc.contributor.authorMuturi, Mathewen
dc.contributor.authorWambua, Lillianen
dc.contributor.authorMiddlebrook, E.A.en
dc.contributor.authorBartlow, A.W.en
dc.contributor.authorFair, J.M.en
dc.contributor.authorBett, Bernard K.en
dc.date.accessioned2023-10-06T10:03:10Zen
dc.date.available2023-10-06T10:03:10Zen
dc.identifier.urihttps://hdl.handle.net/10568/132158
dc.titleSeroprevalence of Brucella spp. and Rift Valley fever virus among slaughterhouse workers in Isiolo County, northern Kenyaen
dcterms.abstractBrucella spp. and Rift Valley fever virus (RVFV) are classified as priority zoonotic agents in Kenya, based on their public health and socioeconomic impact on the country. Data on the pathogen-specific and co-exposure levels is scarce due to limited active surveillance. This study investigated seroprevalence and co-exposure of Brucella spp. and RVFV and associated risk factors among slaughterhouse workers in Isiolo County, northern Kenya. A cross-sectional serosurvey was done in all 19 slaughterhouses in Isiolo County, enrolling 378 participants into the study. The overall seroprevalences for Brucella spp. and RVFV were 40.2% (95% CI: 35.2–45.4) and 18.3% (95% CI: 14.5–22.5), respectively while 10.3% (95% CI 7.4%-13.8%) of individuals were positive for antibodies against both Brucella spp. and RVFV. Virus neutralisation tests (VNT) confirmed anti-RVFV antibodies in 85% of ELISA-positive samples. Our seroprevalence results were comparable to community-level seroprevalences previously reported in the area. Since most of the study participants were not from livestock-keeping households, our findings attribute most of the detected infections to occupational exposure. The high exposure levels indicate slaughterhouse workers are the most at-risk population and there is need for infection, prevention, and control programs among this high-risk group. This is the first VNT confirmation of virus-neutralising antibodies among slaughterhouse workers in Isiolo County and corroborates reports of the area being a high-risk RVFV area as occasioned by previously reported outbreaks. This necessitates sensitization campaigns to enhance awareness of the risks involved and appropriate mitigation measures.en
dcterms.accessRightsOpen Access
dcterms.audienceAcademicsen
dcterms.audienceScientistsen
dcterms.available2023-10-05
dcterms.bibliographicCitationNyamota, R., Maina, J., Akoko, J., Nthiwa, D., Mwatondo, A., Muturi, M., Wambua, L., Middlebrook, E.A., Bartlow, A.W., Fair, J.M. and Bett, B. 2023. Seroprevalence of Brucella spp. and Rift Valley fever virus among slaughterhouse workers in Isiolo County, northern Kenya. PLOS Neglected Tropical Diseases 17(10): e0011677.en
dcterms.extente0011677en
dcterms.issued2023-10-05
dcterms.languageen
dcterms.licenseCC0-1.0
dcterms.publisherPublic Library of Scienceen
dcterms.subjectbrucellosisen
dcterms.subjectrift valley feveren
dcterms.subjectzoonosesen
dcterms.subjecthealthen
dcterms.typeJournal Article

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