Seroprevalence of Brucella spp. and Rift Valley fever virus among slaughterhouse workers in Isiolo County, northern Kenya

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationZoonotic Disease Unit, Kenyaen_US
cg.contributor.affiliationUniversity of Embuen_US
cg.contributor.affiliationFreie Universität Berlinen_US
cg.contributor.affiliationWorld Organisation for Animal Healthen_US
cg.contributor.affiliationLos Alamos National Laboratoryen_US
cg.contributor.donorDefense Threat Reduction Agencyen_US
cg.contributor.donorCGIAR Trust Funden_US
cg.coverage.countryKenyaen_US
cg.coverage.iso3166-alpha2KEen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierRichard Nyamota: 0000-0002-9569-1953en_US
cg.creator.identifierJames Akoko: 0000-0001-5730-4505en_US
cg.creator.identifierAthman Mwatondo: 0000-0002-3180-7013en_US
cg.creator.identifierLillian Wambua: 0000-0003-3632-7411en_US
cg.creator.identifierBernard Bett: 0000-0001-9376-2941en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1371/journal.pntd.0011677en_US
cg.isijournalISI Journalen_US
cg.issn1935-2735en_US
cg.issue10en_US
cg.journalPLOS Neglected Tropical Diseasesen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.actionAreaResilient Agrifood Systemsen_US
cg.subject.ilriBRUCELLOSISen_US
cg.subject.ilriHUMAN HEALTHen_US
cg.subject.ilriRVFen_US
cg.subject.ilriZOONOTIC DISEASESen_US
cg.subject.impactAreaNutrition, health and food securityen_US
cg.subject.impactPlatformNutrition, Health and Food Securityen_US
cg.subject.sdgSDG 3 - Good health and well-beingen_US
cg.volume17en_US
dc.contributor.authorNyamota, Richarden_US
dc.contributor.authorMaina, J.en_US
dc.contributor.authorAkoko, James M.en_US
dc.contributor.authorNthiwa, D.en_US
dc.contributor.authorMwatondo, Athmanen_US
dc.contributor.authorMuturi, Mathewen_US
dc.contributor.authorWambua, Lillianen_US
dc.contributor.authorMiddlebrook, E.A.en_US
dc.contributor.authorBartlow, A.W.en_US
dc.contributor.authorFair, J.M.en_US
dc.contributor.authorBett, Bernard K.en_US
dc.date.accessioned2023-10-06T10:03:10Zen_US
dc.date.available2023-10-06T10:03:10Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/132158en_US
dc.titleSeroprevalence of Brucella spp. and Rift Valley fever virus among slaughterhouse workers in Isiolo County, northern Kenyaen_US
dcterms.abstractBrucella spp. and Rift Valley fever virus (RVFV) are classified as priority zoonotic agents in Kenya, based on their public health and socioeconomic impact on the country. Data on the pathogen-specific and co-exposure levels is scarce due to limited active surveillance. This study investigated seroprevalence and co-exposure of Brucella spp. and RVFV and associated risk factors among slaughterhouse workers in Isiolo County, northern Kenya. A cross-sectional serosurvey was done in all 19 slaughterhouses in Isiolo County, enrolling 378 participants into the study. The overall seroprevalences for Brucella spp. and RVFV were 40.2% (95% CI: 35.2–45.4) and 18.3% (95% CI: 14.5–22.5), respectively while 10.3% (95% CI 7.4%-13.8%) of individuals were positive for antibodies against both Brucella spp. and RVFV. Virus neutralisation tests (VNT) confirmed anti-RVFV antibodies in 85% of ELISA-positive samples. Our seroprevalence results were comparable to community-level seroprevalences previously reported in the area. Since most of the study participants were not from livestock-keeping households, our findings attribute most of the detected infections to occupational exposure. The high exposure levels indicate slaughterhouse workers are the most at-risk population and there is need for infection, prevention, and control programs among this high-risk group. This is the first VNT confirmation of virus-neutralising antibodies among slaughterhouse workers in Isiolo County and corroborates reports of the area being a high-risk RVFV area as occasioned by previously reported outbreaks. This necessitates sensitization campaigns to enhance awareness of the risks involved and appropriate mitigation measures.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceAcademicsen_US
dcterms.audienceScientistsen_US
dcterms.available2023-10-05en_US
dcterms.bibliographicCitationNyamota, R., Maina, J., Akoko, J., Nthiwa, D., Mwatondo, A., Muturi, M., Wambua, L., Middlebrook, E.A., Bartlow, A.W., Fair, J.M. and Bett, B. 2023. Seroprevalence of Brucella spp. and Rift Valley fever virus among slaughterhouse workers in Isiolo County, northern Kenya. PLOS Neglected Tropical Diseases 17(10): e0011677.en_US
dcterms.extente0011677en_US
dcterms.issued2023-10-05en_US
dcterms.languageenen_US
dcterms.licenseCC0-1.0en_US
dcterms.publisherPublic Library of Scienceen_US
dcterms.subjectbrucellosisen_US
dcterms.subjectrift valley feveren_US
dcterms.subjectzoonosesen_US
dcterms.subjecthealthen_US
dcterms.typeJournal Articleen_US

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