Ecological and subject-level drivers of interepidemic Rift Valley fever virus exposure in humans and livestock in Northern Kenya

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationFreie Universität Berlinen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationZoonotic Disease Unit, Kenyaen
cg.contributor.affiliationUniversity of Nairobien
cg.contributor.affiliationWashington State Universityen
cg.contributor.affiliationUniversity of Embuen
cg.contributor.affiliationUniversity of Edinburghen
cg.contributor.donorDefense Threat Reduction Agencyen
cg.contributor.donorCGIAR Trust Funden
cg.contributor.donorProjekt DEALen
cg.coverage.countryKenya
cg.coverage.iso3166-alpha2KE
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierAthman Mwatondo: 0000-0002-3180-7013
cg.creator.identifierJames Akoko: 0000-0001-5730-4505
cg.creator.identifierRichard Nyamota: 0000-0002-9569-1953
cg.creator.identifierLillian Wambua: 0000-0003-3632-7411
cg.creator.identifierKristina Roesel: 0000-0002-2553-1129
cg.creator.identifierBernard Bett: 0000-0001-9376-2941
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1038/s41598-023-42596-yen
cg.isijournalISI Journalen
cg.issn2045-2322en
cg.issue1en
cg.journalScientific Reportsen
cg.reviewStatusPeer Reviewen
cg.subject.actionAreaResilient Agrifood Systems
cg.subject.ilriLIVESTOCKen
cg.subject.ilriRVFen
cg.subject.ilriZOONOTIC DISEASESen
cg.subject.impactAreaNutrition, health and food security
cg.subject.sdgSDG 3 - Good health and well-beingen
cg.volume13en
dc.contributor.authorMuturi, Mathewen
dc.contributor.authorMwatondo, Athmanen
dc.contributor.authorNijhof, A.M.en
dc.contributor.authorAkoko, James M.en
dc.contributor.authorNyamota, Richarden
dc.contributor.authorMakori, A.en
dc.contributor.authorNyamai, M.en
dc.contributor.authorNthiwa, D.en
dc.contributor.authorWambua, Lillianen
dc.contributor.authorRoesel, Kristinaen
dc.contributor.authorThumbi, Samuel M.en
dc.contributor.authorBett, Bernard K.en
dc.date.accessioned2023-09-18T08:00:44Zen
dc.date.available2023-09-18T08:00:44Zen
dc.identifier.urihttps://hdl.handle.net/10568/131882
dc.titleEcological and subject-level drivers of interepidemic Rift Valley fever virus exposure in humans and livestock in Northern Kenyaen
dcterms.abstractNearly a century after the first reports of Rift Valley fever (RVF) were documented in Kenya, questions on the transmission dynamics of the disease remain. Specifically, data on viral maintenance in the quiescent years between epidemics is limited. We implemented a cross-sectional study in northern Kenya to determine the seroprevalence, risk factors, and ecological predictors of RVF in humans and livestock during an interepidemic period. Six hundred seventy-six human and 1,864 livestock samples were screened for anti-RVF Immunoglobulin G (IgG). Out of the 1,864 livestock samples tested for IgG, a subset of 1,103 samples was randomly selected for additional testing to detect the presence of anti-RVFV Immunoglobulin M (IgM). The anti-RVF virus (RVFV) IgG seropositivity in livestock and humans was 21.7% and 28.4%, respectively. RVFV IgM was detected in 0.4% of the livestock samples. Participation in the slaughter of livestock and age were positively associated with RVFV exposure in humans, while age was a significant factor in livestock. We detected significant interaction between rainfall and elevation's influence on livestock seropositivity, while in humans, elevation was negatively associated with RVF virus exposure. The linear increase of human and livestock exposure with age suggests an endemic transmission cycle, further corroborated by the detection of IgM antibodies in livestock.en
dcterms.accessRightsOpen Access
dcterms.audienceAcademicsen
dcterms.audienceScientistsen
dcterms.available2023-09-15
dcterms.bibliographicCitationMuturi, M., Mwatondo, A., Nijhof, A.M., Akoko, J., Nyamota, R., Makori, A., Nyamai, M., Nthiwa, D., Wambua, L., Roesel, K., Thumbi, S.M. and Bett, B. 2023. Ecological and subject-level drivers of interepidemic Rift Valley fever virus exposure in humans and livestock in Northern Kenya. Scientific Reports 13: 15342.en
dcterms.extent15342en
dcterms.issued2023-09-15
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherSpringeren
dcterms.subjectrift valley feveren
dcterms.subjectzoonosesen
dcterms.subjectlivestocken
dcterms.typeJournal Article

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