Ecological and subject-level drivers of interepidemic Rift Valley fever virus exposure in humans and livestock in Northern Kenya

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationFreie Universität Berlinen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationZoonotic Disease Unit, Kenyaen_US
cg.contributor.affiliationUniversity of Nairobien_US
cg.contributor.affiliationWashington State Universityen_US
cg.contributor.affiliationUniversity of Embuen_US
cg.contributor.affiliationUniversity of Edinburghen_US
cg.contributor.donorDefense Threat Reduction Agencyen_US
cg.contributor.donorCGIAR Trust Funden_US
cg.contributor.donorProjekt DEALen_US
cg.coverage.countryKenyaen_US
cg.coverage.iso3166-alpha2KEen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierAthman Mwatondo: 0000-0002-3180-7013en_US
cg.creator.identifierJames Akoko: 0000-0001-5730-4505en_US
cg.creator.identifierRichard Nyamota: 0000-0002-9569-1953en_US
cg.creator.identifierLillian Wambua: 0000-0003-3632-7411en_US
cg.creator.identifierKristina Roesel: 0000-0002-2553-1129en_US
cg.creator.identifierBernard Bett: 0000-0001-9376-2941en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1038/s41598-023-42596-yen_US
cg.isijournalISI Journalen_US
cg.issn2045-2322en_US
cg.issue1en_US
cg.journalScientific Reportsen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.actionAreaResilient Agrifood Systemsen_US
cg.subject.ilriLIVESTOCKen_US
cg.subject.ilriRVFen_US
cg.subject.ilriZOONOTIC DISEASESen_US
cg.subject.impactAreaNutrition, health and food securityen_US
cg.subject.sdgSDG 3 - Good health and well-beingen_US
cg.volume13en_US
dc.contributor.authorMuturi, Mathewen_US
dc.contributor.authorMwatondo, Athmanen_US
dc.contributor.authorNijhof, A.M.en_US
dc.contributor.authorAkoko, James M.en_US
dc.contributor.authorNyamota, Richarden_US
dc.contributor.authorMakori, A.en_US
dc.contributor.authorNyamai, M.en_US
dc.contributor.authorNthiwa, D.en_US
dc.contributor.authorWambua, Lillianen_US
dc.contributor.authorRoesel, Kristinaen_US
dc.contributor.authorThumbi, Samuel M.en_US
dc.contributor.authorBett, Bernard K.en_US
dc.date.accessioned2023-09-18T08:00:44Zen_US
dc.date.available2023-09-18T08:00:44Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/131882en_US
dc.titleEcological and subject-level drivers of interepidemic Rift Valley fever virus exposure in humans and livestock in Northern Kenyaen_US
dcterms.abstractNearly a century after the first reports of Rift Valley fever (RVF) were documented in Kenya, questions on the transmission dynamics of the disease remain. Specifically, data on viral maintenance in the quiescent years between epidemics is limited. We implemented a cross-sectional study in northern Kenya to determine the seroprevalence, risk factors, and ecological predictors of RVF in humans and livestock during an interepidemic period. Six hundred seventy-six human and 1,864 livestock samples were screened for anti-RVF Immunoglobulin G (IgG). Out of the 1,864 livestock samples tested for IgG, a subset of 1,103 samples was randomly selected for additional testing to detect the presence of anti-RVFV Immunoglobulin M (IgM). The anti-RVF virus (RVFV) IgG seropositivity in livestock and humans was 21.7% and 28.4%, respectively. RVFV IgM was detected in 0.4% of the livestock samples. Participation in the slaughter of livestock and age were positively associated with RVFV exposure in humans, while age was a significant factor in livestock. We detected significant interaction between rainfall and elevation's influence on livestock seropositivity, while in humans, elevation was negatively associated with RVF virus exposure. The linear increase of human and livestock exposure with age suggests an endemic transmission cycle, further corroborated by the detection of IgM antibodies in livestock.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceAcademicsen_US
dcterms.audienceScientistsen_US
dcterms.available2023-09-15en_US
dcterms.bibliographicCitationMuturi, M., Mwatondo, A., Nijhof, A.M., Akoko, J., Nyamota, R., Makori, A., Nyamai, M., Nthiwa, D., Wambua, L., Roesel, K., Thumbi, S.M. and Bett, B. 2023. Ecological and subject-level drivers of interepidemic Rift Valley fever virus exposure in humans and livestock in Northern Kenya. Scientific Reports 13: 15342.en_US
dcterms.extent15342en_US
dcterms.issued2023-09-15en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherSpringeren_US
dcterms.subjectrift valley feveren_US
dcterms.subjectzoonosesen_US
dcterms.subjectlivestocken_US
dcterms.typeJournal Articleen_US

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