An integrated study of human and animal infectious disease in the Lake Victoria crescent small-holder crop-livestock production system, Kenya

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationUniversity of Liverpoolen_US
cg.contributor.affiliationUniversity of Edinburghen_US
cg.contributor.affiliationKenya Medical Research Instituteen_US
cg.contributor.affiliationMount Kenya Universityen_US
cg.contributor.crpAgriculture for Nutrition and Healthen_US
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen_US
cg.contributor.donorMedical Research Council, United Kingdomen_US
cg.contributor.donorWellcome Trusten_US
cg.coverage.countryKenyaen_US
cg.coverage.iso3166-alpha2KEen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986en_US
cg.creator.identifierWilliam de Glanville: 0000-0003-2474-0356en_US
cg.creator.identifierLian Thomas: 0000-0001-8447-1210en_US
cg.creator.identifierElizabeth Cook: 0000-0001-6081-8363en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1186/s12879-017-2559-6en_US
cg.isijournalISI Journalen_US
cg.issn1471-2334en_US
cg.issue1en_US
cg.journalBMC Infectious Diseasesen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.ilriANIMAL DISEASESen_US
cg.subject.ilriHEALTHen_US
cg.subject.ilriLIVESTOCKen_US
cg.volume17en_US
dc.contributor.authorFèvre, Eric M.en_US
dc.contributor.authorGlanville, William A. deen_US
dc.contributor.authorThomas, Lian F.en_US
dc.contributor.authorCook, Elizabeth A.J.en_US
dc.contributor.authorKariuki, S.en_US
dc.contributor.authorWamae, C.N.en_US
dc.date.accessioned2017-07-04T09:47:06Zen_US
dc.date.available2017-07-04T09:47:06Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/82635en_US
dc.titleAn integrated study of human and animal infectious disease in the Lake Victoria crescent small-holder crop-livestock production system, Kenyaen_US
dcterms.abstractBackground The neglected zoonotic diseases (NZD) are an understudied group that are a major cause of illness throughout the developing world. In general, little is known about the prevalence and burden of NZDs in affected communities, particularly in relation to other infectious diseases with which they are often co-endemic. We describe the design and descriptive epidemiological outputs from an integrated study of human and animal zoonotic and non-zoonotic disease in a rural farming community in western Kenya. Methods This cross-sectional survey involved 2113 people, their cattle (n = 983) and pigs (n = 91). People and animals were tested for infection or exposure to a wide range of zoonotic and non-zoonotic pathogens. Prevalence estimates, with adjustment for the complex study design, were derived. Evidence for spatial clustering in exposure or infection was identified using the spatial scan statistic. Results There was a high prevalence of human parasitism in the community, particularly with hookworm (Ancylostoma duodenale or Necator americanus) (36.3% (95% CI 32.8–39.9)), Entamoeba histolytica/dispar (30.1% (95% CI 27.5–32.8)), and Plasmodium falciparum (29.4% (95% CI 26.8–32.0)). Human infection with Taenia spp. was also prevalent (19.7% (95% CI 16.7–22.7)), while exposure to other zoonotic pathogens was comparatively rarer (Brucella spp., 0.6% (95% CI 0.2–0.9); Coxiella burnetii, 2.2% (95% CI 1.5–2.9); Rift Valley fever, 0.5% (95% CI 0.2–0.8)). A low prevalence of exposure to Brucella spp. was observed in cattle (0.26% (95% CI 0–0.56). This was higher for Rift Valley fever virus (1.4% (95% CI 0.5–2.22)) and C. burnetii (10.0% (95% CI 7.7–12.2)). The prevalence of Taenia spp. cysticercosis was 53.5% (95% CI 48.7–58.3) in cattle and 17.2% (95% CI 9.1–25.3) in pigs. Mycobacterium bovis infection was found in 2.2% of cattle (95% CI 1.3–3.2), while the prevalence of infection with Mycobacterium spp. was 8.2% (95% CI 6.8–9.6) in people. Conclusion Zoonotic infections in people and animals occur in the context of a wide range of co-endemic pathogens in a rural community in western Kenya. The wide diversity of pathogens under study provides a unique opportunity to explore the distribution and determinants of infection in a multi-pathogen, multi-host system.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceScientistsen_US
dcterms.available2017-06-30en_US
dcterms.bibliographicCitationFèvre, E.M., Glanville, W.A. de, Thomas, L.F., Cook, E.A.J., Kariuki, S. and Wamae, C.N. 2017. An integrated study of human and animal infectious disease in the Lake Victoria crescent small-holder crop-livestock production system, Kenya. BMC Infectious Diseases 17: 457.en_US
dcterms.issued2017-12en_US
dcterms.languageenen_US
dcterms.publisherSpringeren_US
dcterms.subjectanimal diseasesen_US
dcterms.subjecthealthen_US
dcterms.typeJournal Articleen_US

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