Effect of prenatal micronutrient-fortified balanced energy-protein supplementation on maternal and newborn body composition: A sub-study from the MISAME-III randomized controlled efficacy trial in rural Burkina Faso

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR single centreen
cg.contributor.donorBill & Melinda Gates Foundationen
cg.contributor.donorCGIAR Trust Funden
cg.contributor.initiativeSustainable Healthy Diets
cg.coverage.countryBurkina Faso
cg.coverage.iso3166-alpha2BF
cg.coverage.regionWestern Africa
cg.coverage.regionSub-Saharan Africa
cg.coverage.regionAfrica
cg.creator.identifierLieven Huybregts: 0000-0002-3068-2853
cg.identifier.doihttps://doi.org/10.1371/journal.pmed.1004242en
cg.identifier.projectIFPRI - Nutrition, Diets, and Health Unit
cg.identifier.projectIFPRI - Systems Transformation - Food and Nutrition Policy
cg.identifier.publicationRankA Plus
cg.isijournalISI Journalen
cg.issn1549-1277en
cg.issue7en
cg.journalPLoS Meden
cg.reviewStatusPeer Reviewen
cg.volume20en
dc.contributor.authorArgaw, Alemayehuen
dc.contributor.authorToe, Laeticia Celineen
dc.contributor.authorHanley-Cook, Giles T.en
dc.contributor.authorDailey-Chwalibóg, Trentonen
dc.contributor.authorde Kok, Brendaen
dc.contributor.authorOuédraogo, Lionelen
dc.contributor.authorCompaoré, Andersonen
dc.contributor.authorOuédraogo, Moctaren
dc.contributor.authorSawadogo, Amadien
dc.contributor.authorGanaba, Rasmanéen
dc.contributor.authorVanslambrouck, Katrienen
dc.contributor.authorKolsteren, Patricken
dc.contributor.authorLachat, Carlen
dc.contributor.authorHuybregts, Lievenen
dc.date.accessioned2024-03-14T12:08:49Zen
dc.date.available2024-03-14T12:08:49Zen
dc.identifier.urihttps://hdl.handle.net/10568/140002
dc.titleEffect of prenatal micronutrient-fortified balanced energy-protein supplementation on maternal and newborn body composition: A sub-study from the MISAME-III randomized controlled efficacy trial in rural Burkina Fasoen
dcterms.abstractBackground: Micronutrient-fortified balanced energy-protein (BEP) supplements are promising interventions to prevent intrauterine growth retardation in low- and middle-income countries. On the other hand, one concern with blanket prenatal supplementation programs using energy-dense supplements is that they could lead to more maternal and/or infant overweight. However, evidence is lacking on the potential effect of BEP on maternal and offspring body composition. This study evaluates the effects of micronutrient-fortified BEP supplementation during pregnancy on body composition of mothers and their newborns in rural Burkina Faso. Methods and findings: The MISAME-III study is an open label individually randomized controlled trial where pregnant women (n = 1,897) of gestational age <21 weeks received either a combination of micronutrient-fortified BEP and iron-folic acid (IFA) tablets (i.e., intervention) or IFA alone (i.e., control). The prenatal phase of the MISAME-III study was conducted between the first enrollment in October 2019 and the last delivery in August 2021. In a sub-study nested under the MISAME-III trial, we evaluated anthropometry and body composition in newborns who were born starting from 17 November 2020 (n: control = 368 and intervention = 352) and their mothers (n: control = 185 and intervention = 186). Primary study outcomes were newborn and maternal fat-free mass (FFMI) and fat-mass (FMI) indices. We used the deuterium dilution method to determine FFMI and FMI and %FFM and %FM of total body weight within 1 month postpartum. Our main analysis followed a modified intention-to-treat approach by analyzing all subjects with body composition data available. Univariable and multivariable linear regression models were fitted to compare the intervention and control arms, with adjusted models included baseline maternal age, height, arm fat index, hemoglobin concentration and primiparity, household size, wealth and food security indices, and newborn age (days). At study enrollment, the mean ± SD maternal age was 24.8 ± 6.13 years and body mass index (BMI) was 22.1 ± 3.02 kg/m2 with 7.05% of the mothers were underweight and 11.5% were overweight. Prenatal micronutrient-fortified BEP supplementation resulted in a significantly higher FFMI in mothers (MD (mean difference): 0.45; 95% CI (confidence interval): 0.05, 0.84; P = 0.026) and newborns (MD: 0.28; 95% CI: 0.06, 0.50; P = 0.012), whereas no statistically significant effects were found on FMI. The effect of micronutrient-fortified BEP on maternal FFMI was greater among mothers from food secure households and among those with a better nutritional status (BMI ≥21.0 kg/m2 or mid-upper arm circumference (MUAC) ≥23 cm). Key limitations of the study are the relatively high degree of missing data (approximately 18%), the lack of baseline maternal body composition values, and the lack of follow-up body composition measurements to evaluate any long-term effects. Conclusions: Micronutrient-fortified BEP supplementation during pregnancy can increase maternal and newborn FFMI, without significant effects on FMI.en
dcterms.accessRightsOpen Access
dcterms.available2023-07-24
dcterms.bibliographicCitationArgaw, Alemayehu; Toe, Laeticia Celine; Hanley-Cook, Giles; Dailey-Chwalibóg, Trenton; de Kok, Brenda; Huybregts, Lieven; et al. 2023. Effect of prenatal micronutrient-fortified balanced energy-protein supplementation on maternal and newborn body composition: A sub-study from the MISAME-III randomized controlled efficacy trial in rural Burkina Faso. PLoS Med 20(7): e1004242. https://doi.org/10.1371/journal.pmed.1004242en
dcterms.issued2023-07-24
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherPublic Library of Scienceen
dcterms.relationhttps://doi.org/10.1093/jn/nxac171en
dcterms.relationhttps://doi.org/10.1371/journal.pmed.1004002en
dcterms.relationhttps://doi.org/10.1093/jn/nxac104en
dcterms.relationhttps://doi.org/10.1093/jn/nxab289en
dcterms.relationhttps://doi.org/10.1136/bmjopen-2020-038393en
dcterms.replaceshttps://ebrary.ifpri.org/digital/collection/p15738coll5/id/8804en
dcterms.subjectdataen
dcterms.subjectcapacity developmenten
dcterms.subjecttrace elementsen
dcterms.subjectmaternal nutritionen
dcterms.subjectrural areasen
dcterms.subjectperinatal perioden
dcterms.typeJournal Article

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