Serological evidence of single and mixed infections of Rift Valley fever virus, Brucella spp. and Coxiella burnetii in dromedary camels in Kenya

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationZoonotic Disease Unit, Kenyaen
cg.contributor.affiliationUniversity of Embuen
cg.contributor.affiliationUniversity of Nairobien
cg.contributor.affiliationUniversity of Edinburghen
cg.contributor.affiliationWashington State Universityen
cg.contributor.affiliationMinistry of Agriculture, Livestock, Fisheries and Irrigation, Kenyaen
cg.contributor.affiliationFood and Agriculture Organization of the United Nationsen
cg.contributor.crpAgriculture for Nutrition and Health
cg.contributor.donorUnited States Defense Threat Reduction Agencyen
cg.contributor.donorFood and Agriculture Organization of the United Nationsen
cg.coverage.countryKenya
cg.coverage.iso3166-alpha2KE
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierMathew Muturi: 0000-0003-2110-8099
cg.creator.identifierJames Akoko: 0000-0001-5730-4505
cg.creator.identifierRichard Nyamota: 0000-0002-9569-1953
cg.creator.identifierAthman Mwatondo: 0000-0002-3180-7013
cg.creator.identifierBernard Bett: 0000-0001-9376-2941
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1371/journal.pntd.0009275en
cg.isijournalISI Journalen
cg.issn1935-2735en
cg.issue3en
cg.journalPLOS Neglected Tropical Diseasesen
cg.reviewStatusPeer Reviewen
cg.subject.ilriANIMAL DISEASESen
cg.subject.ilriBRUCELLOSISen
cg.subject.ilriCAMELSen
cg.subject.ilriLIVESTOCKen
cg.subject.ilriRVFen
cg.subject.ilriZOONOTIC DISEASESen
cg.subject.impactAreaNutrition, health and food security
cg.subject.sdgSDG 2 - Zero hungeren
cg.subject.sdgSDG 3 - Good health and well-beingen
cg.volume15en
dc.contributor.authorMuturi, M.en
dc.contributor.authorAkoko, James M.en
dc.contributor.authorNthiwa, D.en
dc.contributor.authorChege, B.en
dc.contributor.authorNyamota, Richarden
dc.contributor.authorMutiiria, M.en
dc.contributor.authorMaina, Josphaten
dc.contributor.authorThumbi, Samuel M.en
dc.contributor.authorNyamai, M.en
dc.contributor.authorKahariri, S.en
dc.contributor.authorSitawa, R.en
dc.contributor.authorKimutai, J.en
dc.contributor.authorKuria, W.en
dc.contributor.authorMwatondo, Athmanen
dc.contributor.authorBett, Bernard K.en
dc.date.accessioned2021-03-28T18:48:59Zen
dc.date.available2021-03-28T18:48:59Zen
dc.identifier.urihttps://hdl.handle.net/10568/113148
dc.titleSerological evidence of single and mixed infections of Rift Valley fever virus, Brucella spp. and Coxiella burnetii in dromedary camels in Kenyaen
dcterms.abstractCamels are increasingly becoming the livestock of choice for pastoralists reeling from effects of climate change in semi-arid and arid parts of Kenya. As the population of camels rises, better understanding of their role in the epidemiology of zoonotic diseases in Kenya is a public health priority. Rift Valley fever (RVF), brucellosis and Q fever are three of the top priority diseases in the country but the involvement of camels in the transmission dynamics of these diseases is poorly understood. We analyzed 120 camel serum samples from northern Kenya to establish seropositivity rates of the three pathogens and to characterize the infecting Brucella species using molecular assays. We found seropositivity of 24.2% (95% confidence interval [CI]: 16.5-31.8%) for Brucella, 20.8% (95% CI: 13.6-28.1%) and 14.2% (95% CI: 7.9-20.4%) for Coxiella burnetii and Rift valley fever virus respectively. We found 27.5% (95% CI: 19.5-35.5%) of the animals were seropositive for at least one pathogen and 13.3% (95% CI: 7.2-19.4%) were seropositive for at least two pathogens. B. melitensis was the only Brucella spp. detected. The high sero-positivity rates are indicative of the endemicity of these pathogens among camel populations and the possible role the species has in the epidemiology of zoonotic diseases. Considering the strong association between human infection and contact with livestock for most zoonotic infections in Kenya, there is immediate need to conduct further research to determine the role of camels in transmission of these zoonoses to other livestock species and humans. This information will be useful for designing more effective surveillance systems and intervention measures.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.available2021-03-26
dcterms.bibliographicCitationMuturi, M., Akoko, J., Nthiwa, D., Chege, B., Nyamota, R., Mutiiria, M., Maina, J., Thumbi, S.M., Nyamai, M., Kahariri, S., Sitawa, R., Kimutai, J., Kuria, W., Mwatondo, A. and Bett, B. 2021. Serological evidence of single and mixed infections of Rift Valley fever virus, Brucella spp. and Coxiella burnetii in dromedary camels in Kenya. PLOS Neglected Tropical Diseases 15(3): e0009275.en
dcterms.extente0009275en
dcterms.issued2021-03-26
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherPublic Library of Scienceen
dcterms.subjectanimal diseasesen
dcterms.subjectzoonosesen
dcterms.subjectrift valley feveren
dcterms.subjectbrucellaen
dcterms.subjectcoxiella burnetiien
dcterms.subjectcamelsen
dcterms.subjectlivestocken
dcterms.typeJournal Article

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