Serological evidence of single and mixed infections of Rift Valley fever virus, Brucella spp. and Coxiella burnetii in dromedary camels in Kenya

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationZoonotic Disease Unit, Kenyaen_US
cg.contributor.affiliationUniversity of Embuen_US
cg.contributor.affiliationUniversity of Nairobien_US
cg.contributor.affiliationUniversity of Edinburghen_US
cg.contributor.affiliationWashington State Universityen_US
cg.contributor.affiliationMinistry of Agriculture, Livestock, Fisheries and Irrigation, Kenyaen_US
cg.contributor.affiliationFood and Agriculture Organization of the United Nationsen_US
cg.contributor.crpAgriculture for Nutrition and Healthen_US
cg.contributor.donorUnited States Defense Threat Reduction Agencyen_US
cg.contributor.donorFood and Agriculture Organization of the United Nationsen_US
cg.coverage.countryKenyaen_US
cg.coverage.iso3166-alpha2KEen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierMathew Muturi: 0000-0003-2110-8099en_US
cg.creator.identifierJames Akoko: 0000-0001-5730-4505en_US
cg.creator.identifierRichard Nyamota: 0000-0002-9569-1953en_US
cg.creator.identifierAthman Mwatondo: 0000-0002-3180-7013en_US
cg.creator.identifierBernard Bett: 0000-0001-9376-2941en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1371/journal.pntd.0009275en_US
cg.isijournalISI Journalen_US
cg.issn1935-2735en_US
cg.issue3en_US
cg.journalPLOS Neglected Tropical Diseasesen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.ilriANIMAL DISEASESen_US
cg.subject.ilriBRUCELLOSISen_US
cg.subject.ilriCAMELSen_US
cg.subject.ilriLIVESTOCKen_US
cg.subject.ilriRVFen_US
cg.subject.ilriZOONOTIC DISEASESen_US
cg.subject.impactAreaNutrition, health and food securityen_US
cg.subject.sdgSDG 2 - Zero hungeren_US
cg.subject.sdgSDG 3 - Good health and well-beingen_US
cg.volume15en_US
dc.contributor.authorMuturi, M.en_US
dc.contributor.authorAkoko, James M.en_US
dc.contributor.authorNthiwa, D.en_US
dc.contributor.authorChege, B.en_US
dc.contributor.authorNyamota, Richarden_US
dc.contributor.authorMutiiria, M.en_US
dc.contributor.authorMaina, Josphaten_US
dc.contributor.authorThumbi, Samuel M.en_US
dc.contributor.authorNyamai, M.en_US
dc.contributor.authorKahariri, S.en_US
dc.contributor.authorSitawa, R.en_US
dc.contributor.authorKimutai, J.en_US
dc.contributor.authorKuria, W.en_US
dc.contributor.authorMwatondo, Athmanen_US
dc.contributor.authorBett, Bernard K.en_US
dc.date.accessioned2021-03-28T18:48:59Zen_US
dc.date.available2021-03-28T18:48:59Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/113148en_US
dc.titleSerological evidence of single and mixed infections of Rift Valley fever virus, Brucella spp. and Coxiella burnetii in dromedary camels in Kenyaen_US
dcterms.abstractCamels are increasingly becoming the livestock of choice for pastoralists reeling from effects of climate change in semi-arid and arid parts of Kenya. As the population of camels rises, better understanding of their role in the epidemiology of zoonotic diseases in Kenya is a public health priority. Rift Valley fever (RVF), brucellosis and Q fever are three of the top priority diseases in the country but the involvement of camels in the transmission dynamics of these diseases is poorly understood. We analyzed 120 camel serum samples from northern Kenya to establish seropositivity rates of the three pathogens and to characterize the infecting Brucella species using molecular assays. We found seropositivity of 24.2% (95% confidence interval [CI]: 16.5-31.8%) for Brucella, 20.8% (95% CI: 13.6-28.1%) and 14.2% (95% CI: 7.9-20.4%) for Coxiella burnetii and Rift valley fever virus respectively. We found 27.5% (95% CI: 19.5-35.5%) of the animals were seropositive for at least one pathogen and 13.3% (95% CI: 7.2-19.4%) were seropositive for at least two pathogens. B. melitensis was the only Brucella spp. detected. The high sero-positivity rates are indicative of the endemicity of these pathogens among camel populations and the possible role the species has in the epidemiology of zoonotic diseases. Considering the strong association between human infection and contact with livestock for most zoonotic infections in Kenya, there is immediate need to conduct further research to determine the role of camels in transmission of these zoonoses to other livestock species and humans. This information will be useful for designing more effective surveillance systems and intervention measures.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceScientistsen_US
dcterms.available2021-03-26en_US
dcterms.bibliographicCitationMuturi, M., Akoko, J., Nthiwa, D., Chege, B., Nyamota, R., Mutiiria, M., Maina, J., Thumbi, S.M., Nyamai, M., Kahariri, S., Sitawa, R., Kimutai, J., Kuria, W., Mwatondo, A. and Bett, B. 2021. Serological evidence of single and mixed infections of Rift Valley fever virus, Brucella spp. and Coxiella burnetii in dromedary camels in Kenya. PLOS Neglected Tropical Diseases 15(3): e0009275.en_US
dcterms.extente0009275en_US
dcterms.issued2021-03-26en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherPublic Library of Scienceen_US
dcterms.subjectanimal diseasesen_US
dcterms.subjectzoonosesen_US
dcterms.subjectrift valley feveren_US
dcterms.subjectbrucellaen_US
dcterms.subjectcoxiella burnetiien_US
dcterms.subjectcamelsen_US
dcterms.subjectlivestocken_US
dcterms.typeJournal Articleen_US

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