Epidemiology of antimicrobial-resistant Escherichia coli carriage in sympatric humans and livestock in a rapidly urbanizing city

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationUniversity of Edinburghen_US
cg.contributor.affiliationUniversity of Liverpoolen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationUniversity of Oxforden_US
cg.contributor.affiliationFood and Agriculture Organization of the United Nationsen_US
cg.contributor.affiliationKenya Medical Research Instituteen_US
cg.contributor.crpAgriculture for Nutrition and Healthen_US
cg.contributor.donorMedical Research Council, United Kingdomen_US
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen_US
cg.contributor.donorEconomic and Social Research Council, United Kingdomen_US
cg.contributor.donorNatural Environment Research Council, United Kingdomen_US
cg.contributor.donorDarwin Trust of Edinburghen_US
cg.contributor.donorWellcome Trusten_US
cg.contributor.donorJoint Programming Initiative on Antimicrobial Resistanceen_US
cg.coverage.countryKenyaen_US
cg.coverage.iso3166-alpha2KEen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierDishon Muloi: 0000-0002-6236-2280en_US
cg.creator.identifierJudy Bettridge: 0000-0002-3917-4660en_US
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986en_US
cg.creator.identifierJames Hassell: 0000-0002-4710-2827en_US
cg.creator.identifierTimothy Robinson: 0000-0002-4266-963Xen_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1016/j.ijantimicag.2019.08.014en_US
cg.isijournalISI Journalen_US
cg.issn0924-8579en_US
cg.issue5en_US
cg.journalInternational Journal of Antimicrobial Agentsen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.ilriAGRI-HEALTHen_US
cg.subject.ilriAMRen_US
cg.subject.ilriEPIDEMIOLOGYen_US
cg.subject.ilriHEALTHen_US
cg.subject.ilriLIVESTOCKen_US
cg.subject.ilriZOONOTIC DISEASESen_US
cg.volume54en_US
dc.contributor.authorMuloi, Dishon M.en_US
dc.contributor.authorKiiru, J.en_US
dc.contributor.authorWard, M.J.en_US
dc.contributor.authorHassell, James M.en_US
dc.contributor.authorBettridge, Judy M.en_US
dc.contributor.authorRobinson, Timothy P.en_US
dc.contributor.authorBunnik, B.A.D. vanen_US
dc.contributor.authorChase-Topping, M.en_US
dc.contributor.authorRobertson, G.en_US
dc.contributor.authorPedersen, A.B.en_US
dc.contributor.authorFèvre, Eric M.en_US
dc.contributor.authorWoolhouse, Mark E.J.en_US
dc.contributor.authorKang'ethe, Erastus K.en_US
dc.contributor.authorKariuki, S.en_US
dc.date.accessioned2019-08-29T09:17:44Zen_US
dc.date.available2019-08-29T09:17:44Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/103445en_US
dc.titleEpidemiology of antimicrobial-resistant Escherichia coli carriage in sympatric humans and livestock in a rapidly urbanizing cityen_US
dcterms.abstractThere are substantial limitations in our understanding of the distribution of antimicrobial resistance (AMR) in humans and livestock in developing countries. Here, we present the results of an epidemiological study examining patterns of AMR in Escherichia coli isolates circulating in sympatric human (n=321) and livestock (n=633) samples from 99 households across Nairobi, Kenya. E. coli isolates were tested for susceptibility to 13 antimicrobial drugs representing 9 antibiotic classes. We detected high rates of AMR, with 47.6% and 21.1% of isolates displaying resistance to ≥ 3 and ≥5 antibiotic classes respectively. Human isolates showed higher levels of resistance to sulfonamides, trimethoprim, aminoglycosides and penicillins compared to livestock (p<0.01), while poultry isolates were more resistant to tetracyclines (p=0.01) compared to humans. The most common co-resistant phenotype observed was to tetracyclines, streptomycin and trimethoprim (30.5%). At the household level, AMR carriage in humans was associated with human density (p<0.01) and the presence of livestock manure (p=0.03), but livestock keeping on its own had no influence on human AMR carriage (p>0.05). Our findings revealed a high prevalence of AMR E. coli circulating in healthy humans and livestock in Nairobi, with no evidence to suggest that keeping livestock, when treated as a single risk factor significantly contributed to the burden of AMR in humans, although the presence of livestock waste was significant. These results provide an understanding of the broader epidemiology of AMR in complex, and interconnected urban environments.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceScientistsen_US
dcterms.bibliographicCitationMuloi, D., Kiiru, J., Ward, M.J., Hassell, J.M., Bettridge, J.M., Robinson, T.P., Bunnik, B.A.D. van, Chase-Topping, M., Robertson, G., Pedersen, A.B., Fèvre, E.M., Woolhouse, M.E.J., Kang'ethe, E.K. and Kariuki, S. 2019. Epidemiology of antimicrobial-resistant Escherichia coli carriage in sympatric humans and livestock in a rapidly urbanizing city. International Journal of Antimicrobial Agents 54(5): 531–537.en_US
dcterms.extentp. 531-537en_US
dcterms.issued2019-11en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherElsevieren_US
dcterms.subjectzoonosesen_US
dcterms.subjectepidemiologyen_US
dcterms.subjectlivestocken_US
dcterms.subjecturban agricultureen_US
dcterms.subjecthealthen_US
dcterms.subjectantimicrobial resistanceen_US
dcterms.typeJournal Articleen_US

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