Epidemiology of antimicrobial-resistant Escherichia coli carriage in sympatric humans and livestock in a rapidly urbanizing city

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationUniversity of Edinburghen
cg.contributor.affiliationUniversity of Liverpoolen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationUniversity of Oxforden
cg.contributor.affiliationFood and Agriculture Organization of the United Nationsen
cg.contributor.affiliationKenya Medical Research Instituteen
cg.contributor.crpAgriculture for Nutrition and Health
cg.contributor.donorMedical Research Council, United Kingdomen
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen
cg.contributor.donorEconomic and Social Research Council, United Kingdomen
cg.contributor.donorNatural Environment Research Council, United Kingdomen
cg.contributor.donorDarwin Trust of Edinburghen
cg.contributor.donorWellcome Trusten
cg.contributor.donorJoint Programming Initiative on Antimicrobial Resistanceen
cg.coverage.countryKenya
cg.coverage.iso3166-alpha2KE
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierDishon Muloi: 0000-0002-6236-2280en
cg.creator.identifierJudy Bettridge: 0000-0002-3917-4660en
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986en
cg.creator.identifierJames Hassell: 0000-0002-4710-2827en
cg.creator.identifierTimothy Robinson: 0000-0002-4266-963Xen
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1016/j.ijantimicag.2019.08.014en
cg.isijournalISI Journalen
cg.issn0924-8579en
cg.issue5en
cg.journalInternational Journal of Antimicrobial Agentsen
cg.reviewStatusPeer Reviewen
cg.subject.ilriAGRI-HEALTHen
cg.subject.ilriAMRen
cg.subject.ilriEPIDEMIOLOGYen
cg.subject.ilriHEALTHen
cg.subject.ilriLIVESTOCKen
cg.subject.ilriZOONOTIC DISEASESen
cg.volume54en
dc.contributor.authorMuloi, Dishon M.en
dc.contributor.authorKiiru, J.en
dc.contributor.authorWard, M.J.en
dc.contributor.authorHassell, James M.en
dc.contributor.authorBettridge, Judy M.en
dc.contributor.authorRobinson, Timothy P.en
dc.contributor.authorBunnik, B.A.D. vanen
dc.contributor.authorChase-Topping, M.en
dc.contributor.authorRobertson, G.en
dc.contributor.authorPedersen, A.B.en
dc.contributor.authorFèvre, Eric M.en
dc.contributor.authorWoolhouse, Mark E.J.en
dc.contributor.authorKang'ethe, Erastus K.en
dc.contributor.authorKariuki, S.en
dc.date.accessioned2019-08-29T09:17:44Zen
dc.date.available2019-08-29T09:17:44Zen
dc.identifier.urihttps://hdl.handle.net/10568/103445
dc.titleEpidemiology of antimicrobial-resistant Escherichia coli carriage in sympatric humans and livestock in a rapidly urbanizing cityen
dcterms.abstractThere are substantial limitations in our understanding of the distribution of antimicrobial resistance (AMR) in humans and livestock in developing countries. Here, we present the results of an epidemiological study examining patterns of AMR in Escherichia coli isolates circulating in sympatric human (n=321) and livestock (n=633) samples from 99 households across Nairobi, Kenya. E. coli isolates were tested for susceptibility to 13 antimicrobial drugs representing 9 antibiotic classes. We detected high rates of AMR, with 47.6% and 21.1% of isolates displaying resistance to ≥ 3 and ≥5 antibiotic classes respectively. Human isolates showed higher levels of resistance to sulfonamides, trimethoprim, aminoglycosides and penicillins compared to livestock (p<0.01), while poultry isolates were more resistant to tetracyclines (p=0.01) compared to humans. The most common co-resistant phenotype observed was to tetracyclines, streptomycin and trimethoprim (30.5%). At the household level, AMR carriage in humans was associated with human density (p<0.01) and the presence of livestock manure (p=0.03), but livestock keeping on its own had no influence on human AMR carriage (p>0.05). Our findings revealed a high prevalence of AMR E. coli circulating in healthy humans and livestock in Nairobi, with no evidence to suggest that keeping livestock, when treated as a single risk factor significantly contributed to the burden of AMR in humans, although the presence of livestock waste was significant. These results provide an understanding of the broader epidemiology of AMR in complex, and interconnected urban environments.en
dcterms.accessRightsOpen Access
dcterms.audienceScientistsen
dcterms.bibliographicCitationMuloi, D., Kiiru, J., Ward, M.J., Hassell, J.M., Bettridge, J.M., Robinson, T.P., Bunnik, B.A.D. van, Chase-Topping, M., Robertson, G., Pedersen, A.B., Fèvre, E.M., Woolhouse, M.E.J., Kang'ethe, E.K. and Kariuki, S. 2019. Epidemiology of antimicrobial-resistant Escherichia coli carriage in sympatric humans and livestock in a rapidly urbanizing city. International Journal of Antimicrobial Agents 54(5): 531–537.en
dcterms.extentp. 531-537en
dcterms.issued2019-11en
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherElsevieren
dcterms.subjectzoonosesen
dcterms.subjectepidemiologyen
dcterms.subjectlivestocken
dcterms.subjecturban agricultureen
dcterms.subjecthealthen
dcterms.subjectantimicrobial resistanceen
dcterms.typeJournal Article

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