Epidemiological connectivity between humans and animals across an urban landscape

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationSmithsonian National Zoo and Conservation Biology Instituteen_US
cg.contributor.affiliationYale School of Public Healthen_US
cg.contributor.affiliationUniversity of Liverpoolen_US
cg.contributor.affiliationUniversity of Edinburghen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationUniversity of Minnesotaen_US
cg.contributor.affiliationUniversity of Oxforden_US
cg.contributor.affiliationUniversity of Southamptonen_US
cg.contributor.affiliationUniversity of Nairobien_US
cg.contributor.affiliationKenya Medical Research Instituteen_US
cg.contributor.affiliationNational Museums of Kenyaen_US
cg.contributor.affiliationHokkaido Universityen_US
cg.contributor.affiliationColumbia Universityen_US
cg.contributor.affiliationKenya Wildlife Serviceen_US
cg.contributor.affiliationUniversità degli Studi di Milanoen_US
cg.contributor.affiliationFood and Agriculture Organization of the United Nationsen_US
cg.contributor.donorMedical Research Council, United Kingdomen_US
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen_US
cg.contributor.donorEconomic and Social Research Council, United Kingdomen_US
cg.contributor.donorNatural Environment Research Council, United Kingdomen_US
cg.contributor.donorCGIAR Trust Funden_US
cg.contributor.donorWellcome Trusten_US
cg.contributor.initiativeOne Healthen_US
cg.coverage.countryKenyaen_US
cg.coverage.iso3166-alpha2KEen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierJames Hassell: 0000-0002-4710-2827en_US
cg.creator.identifierDishon Muloi: 0000-0002-6236-2280en_US
cg.creator.identifierJudy Bettridge: 0000-0002-3917-4660en_US
cg.creator.identifierJames Akoko: 0000-0001-5730-4505en_US
cg.creator.identifierMaurice Murungi: 0000-0001-6467-4352en_US
cg.creator.identifierPatrick Muinde: 0000-0003-3907-7710en_US
cg.creator.identifierLorren Alumasa: 0000-0002-1723-0510en_US
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986en_US
cg.creator.identifierFrancesco Pietro Fava: 0000-0003-3748-7417en_US
cg.creator.identifierMark Woolhouse: 0000-0003-3765-8167en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.dataurlhttps://doi.org/10.17638/datacat.liverpool.ac.uk/2236en_US
cg.identifier.doihttps://doi.org/10.1073/pnas.2218860120en_US
cg.isijournalISI Journalen_US
cg.issn0027-8424en_US
cg.issue29en_US
cg.journalProceedings of the National Academy of Sciences of the United States of Americaen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.actionAreaResilient Agrifood Systemsen_US
cg.subject.ilriANIMAL HEALTHen_US
cg.subject.ilriEPIDEMIOLOGYen_US
cg.subject.ilriHUMAN HEALTHen_US
cg.subject.ilriONE HEALTHen_US
cg.subject.ilriWILDLIFEen_US
cg.subject.ilriZOONOTIC DISEASESen_US
cg.subject.impactAreaNutrition, health and food securityen_US
cg.subject.sdgSDG 3 - Good health and well-beingen_US
cg.volume120en_US
dc.contributor.authorHassell, James M.en_US
dc.contributor.authorMuloi, Dishon M.en_US
dc.contributor.authorVanderWaal, K.L.en_US
dc.contributor.authorWard, M.J.en_US
dc.contributor.authorBettridge, Judy M.en_US
dc.contributor.authorGitahi, N.en_US
dc.contributor.authorOuko, T.en_US
dc.contributor.authorImboma, Titusen_US
dc.contributor.authorAkoko, James M.en_US
dc.contributor.authorKarani, Maurice K.en_US
dc.contributor.authorMuinde, Patricken_US
dc.contributor.authorNakamura, Y.en_US
dc.contributor.authorAlumasa, Lorrenen_US
dc.contributor.authorFurmaga, E.en_US
dc.contributor.authorKaitho, T.en_US
dc.contributor.authorAmanya, Fredricken_US
dc.contributor.authorOgendo, Allanen_US
dc.contributor.authorFava, Francesco P.en_US
dc.contributor.authorWee, B.A.en_US
dc.contributor.authorPhan, H.en_US
dc.contributor.authorKiiru, J.en_US
dc.contributor.authorKang'ethe, Erastus K.en_US
dc.contributor.authorKariuki, S.en_US
dc.contributor.authorRobinson, T.en_US
dc.contributor.authorBegon, M.en_US
dc.contributor.authorWoolhouse, Mark E.J.en_US
dc.contributor.authorFèvre, Eric M.en_US
dc.date.accessioned2023-07-17T07:23:06Zen_US
dc.date.available2023-07-17T07:23:06Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/131165en_US
dc.titleEpidemiological connectivity between humans and animals across an urban landscapeen_US
dcterms.abstractUrbanization is predicted to be a key driver of disease emergence through human exposure to novel, animal-borne pathogens. However, while we suspect that urban landscapes are primed to expose people to novel animal-borne diseases, evidence for the mechanisms by which this occurs is lacking. To address this, we studied how bacterial genes are shared between wild animals, livestock, and humans (n = 1,428) across Nairobi, Kenya—one of the world’s most rapidly developing cities. Applying a multilayer network framework, we show that low biodiversity (of both natural habitat and vertebrate wildlife communities), coupled with livestock management practices and more densely populated urban environments, promotes sharing of Escherichia coli–borne bacterial mobile genetic elements between animals and humans. These results provide empirical support for hypotheses linking resource provision, the biological simplification of urban landscapes, and human and livestock demography to urban dynamics of cross-species pathogen transmission at a landscape scale. Urban areas where high densities of people and livestock live in close association with synanthropes (species such as rodents that are more competent reservoirs for zoonotic pathogens) should be prioritized for disease surveillance and control.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceAcademicsen_US
dcterms.audienceScientistsen_US
dcterms.available2023-07-14en_US
dcterms.bibliographicCitationHassell, J.M., Muloi, D.M., VanderWaal, K.L., Ward, M.J., Bettridge, J., Gitahi, N., Ouko, T., Imboma, T., Akoko, J., Karani, M., Muinde, P., Nakamura, Y., Alumasa, L., Furmaga, E., Kaitho, T., Amanya, F., Ogendo, A., Fava, F., Wee, B.A., Phan, H., Kiiru, J., Kang'ethe, E., Kariuki, S., Robinson, T., Begon, M., Woolhouse, M.E.J. and Fèvre, E.M. 2023. Epidemiological connectivity between humans and animals across an urban landscape. Proceedings of the National Academy of Sciences of the United States of America 120(29): e2218860120.en_US
dcterms.extente2218860120en_US
dcterms.issued2023-07-18en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherNational Academy of Sciencesen_US
dcterms.subjectepidemiologyen_US
dcterms.subjectzoonosesen_US
dcterms.subjectanimal healthen_US
dcterms.subjecthealthen_US
dcterms.subjectwildlifeen_US
dcterms.subjectone health approachen_US
dcterms.subjecturbanizationen_US
dcterms.typeJournal Articleen_US

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Epidemiology, ecology and socio-economics of disease emergence in Nairobi (Urban Zoo)
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