Epidemiological connectivity between humans and animals across an urban landscape

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationSmithsonian National Zoo and Conservation Biology Instituteen
cg.contributor.affiliationYale School of Public Healthen
cg.contributor.affiliationUniversity of Liverpoolen
cg.contributor.affiliationUniversity of Edinburghen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationUniversity of Minnesotaen
cg.contributor.affiliationUniversity of Oxforden
cg.contributor.affiliationUniversity of Southamptonen
cg.contributor.affiliationUniversity of Nairobien
cg.contributor.affiliationKenya Medical Research Instituteen
cg.contributor.affiliationNational Museums of Kenyaen
cg.contributor.affiliationHokkaido Universityen
cg.contributor.affiliationColumbia Universityen
cg.contributor.affiliationKenya Wildlife Serviceen
cg.contributor.affiliationUniversità degli Studi di Milanoen
cg.contributor.affiliationFood and Agriculture Organization of the United Nationsen
cg.contributor.donorMedical Research Council, United Kingdomen
cg.contributor.donorBiotechnology and Biological Sciences Research Council, United Kingdomen
cg.contributor.donorEconomic and Social Research Council, United Kingdomen
cg.contributor.donorNatural Environment Research Council, United Kingdomen
cg.contributor.donorCGIAR Trust Funden
cg.contributor.donorWellcome Trusten
cg.contributor.initiativeOne Health
cg.coverage.countryKenya
cg.coverage.iso3166-alpha2KE
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierJames Hassell: 0000-0002-4710-2827en
cg.creator.identifierDishon Muloi: 0000-0002-6236-2280en
cg.creator.identifierJudy Bettridge: 0000-0002-3917-4660en
cg.creator.identifierJames Akoko: 0000-0001-5730-4505en
cg.creator.identifierMaurice Murungi: 0000-0001-6467-4352en
cg.creator.identifierPatrick Muinde: 0000-0003-3907-7710en
cg.creator.identifierLorren Alumasa: 0000-0002-1723-0510en
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986en
cg.creator.identifierFrancesco Pietro Fava: 0000-0003-3748-7417en
cg.creator.identifierMark Woolhouse: 0000-0003-3765-8167en
cg.howPublishedFormally Publisheden
cg.identifier.dataurlhttps://doi.org/10.17638/datacat.liverpool.ac.uk/2236en
cg.identifier.doihttps://doi.org/10.1073/pnas.2218860120en
cg.isijournalISI Journalen
cg.issn0027-8424en
cg.issue29en
cg.journalProceedings of the National Academy of Sciences of the United States of Americaen
cg.reviewStatusPeer Reviewen
cg.subject.actionAreaResilient Agrifood Systems
cg.subject.ilriANIMAL HEALTHen
cg.subject.ilriEPIDEMIOLOGYen
cg.subject.ilriHUMAN HEALTHen
cg.subject.ilriONE HEALTHen
cg.subject.ilriWILDLIFEen
cg.subject.ilriZOONOTIC DISEASESen
cg.subject.impactAreaNutrition, health and food security
cg.subject.sdgSDG 3 - Good health and well-beingen
cg.volume120en
dc.contributor.authorHassell, James M.en
dc.contributor.authorMuloi, Dishon M.en
dc.contributor.authorVanderWaal, K.L.en
dc.contributor.authorWard, M.J.en
dc.contributor.authorBettridge, Judy M.en
dc.contributor.authorGitahi, N.en
dc.contributor.authorOuko, T.en
dc.contributor.authorImboma, Titusen
dc.contributor.authorAkoko, James M.en
dc.contributor.authorKarani, Maurice K.en
dc.contributor.authorMuinde, Patricken
dc.contributor.authorNakamura, Y.en
dc.contributor.authorAlumasa, Lorrenen
dc.contributor.authorFurmaga, E.en
dc.contributor.authorKaitho, T.en
dc.contributor.authorAmanya, Fredricken
dc.contributor.authorOgendo, Allanen
dc.contributor.authorFava, Francesco P.en
dc.contributor.authorWee, B.A.en
dc.contributor.authorPhan, H.en
dc.contributor.authorKiiru, J.en
dc.contributor.authorKang'ethe, Erastus K.en
dc.contributor.authorKariuki, S.en
dc.contributor.authorRobinson, T.en
dc.contributor.authorBegon, M.en
dc.contributor.authorWoolhouse, Mark E.J.en
dc.contributor.authorFèvre, Eric M.en
dc.date.accessioned2023-07-17T07:23:06Zen
dc.date.available2023-07-17T07:23:06Zen
dc.identifier.urihttps://hdl.handle.net/10568/131165
dc.titleEpidemiological connectivity between humans and animals across an urban landscapeen
dcterms.abstractUrbanization is predicted to be a key driver of disease emergence through human exposure to novel, animal-borne pathogens. However, while we suspect that urban landscapes are primed to expose people to novel animal-borne diseases, evidence for the mechanisms by which this occurs is lacking. To address this, we studied how bacterial genes are shared between wild animals, livestock, and humans (n = 1,428) across Nairobi, Kenya—one of the world’s most rapidly developing cities. Applying a multilayer network framework, we show that low biodiversity (of both natural habitat and vertebrate wildlife communities), coupled with livestock management practices and more densely populated urban environments, promotes sharing of Escherichia coli–borne bacterial mobile genetic elements between animals and humans. These results provide empirical support for hypotheses linking resource provision, the biological simplification of urban landscapes, and human and livestock demography to urban dynamics of cross-species pathogen transmission at a landscape scale. Urban areas where high densities of people and livestock live in close association with synanthropes (species such as rodents that are more competent reservoirs for zoonotic pathogens) should be prioritized for disease surveillance and control.en
dcterms.accessRightsOpen Access
dcterms.audienceAcademicsen
dcterms.audienceScientistsen
dcterms.available2023-07-14en
dcterms.bibliographicCitationHassell, J.M., Muloi, D.M., VanderWaal, K.L., Ward, M.J., Bettridge, J., Gitahi, N., Ouko, T., Imboma, T., Akoko, J., Karani, M., Muinde, P., Nakamura, Y., Alumasa, L., Furmaga, E., Kaitho, T., Amanya, F., Ogendo, A., Fava, F., Wee, B.A., Phan, H., Kiiru, J., Kang'ethe, E., Kariuki, S., Robinson, T., Begon, M., Woolhouse, M.E.J. and Fèvre, E.M. 2023. Epidemiological connectivity between humans and animals across an urban landscape. Proceedings of the National Academy of Sciences of the United States of America 120(29): e2218860120.en
dcterms.extente2218860120en
dcterms.issued2023-07-18en
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherNational Academy of Sciencesen
dcterms.subjectepidemiologyen
dcterms.subjectzoonosesen
dcterms.subjectanimal healthen
dcterms.subjecthealthen
dcterms.subjectwildlifeen
dcterms.subjectone health approachen
dcterms.subjecturbanizationen
dcterms.typeJournal Article

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Epidemiology, ecology and socio-economics of disease emergence in Nairobi (Urban Zoo)
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