Multi-drug resistant Staphylococcus aureus carriage in abattoir workers in Busia, Kenya

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationUniversity of Nairobien
cg.contributor.affiliationOhio State Universityen
cg.contributor.affiliationKenya Medical Research Instituteen
cg.contributor.affiliationPublic Health Scotlanden
cg.contributor.affiliationUniversity of Liverpoolen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationUniversity of Cambridgeen
cg.contributor.crpAgriculture for Nutrition and Health
cg.contributor.donorNational Institutes of Health, United Statesen
cg.contributor.donorCGIAR Trust Funden
cg.contributor.donorMedical Research Council, United Kingdomen
cg.contributor.donorWellcome Trusten
cg.contributor.donorDepartment of Health, United Kingdomen
cg.contributor.initiativeOne Health
cg.coverage.countryKenya
cg.coverage.iso3166-alpha2KE
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986en
cg.creator.identifierElizabeth Cook: 0000-0001-6081-8363en
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.3390/antibiotics11121726en
cg.isijournalISI Journalen
cg.issn2079-6382en
cg.issue12en
cg.journalAntibioticsen
cg.reviewStatusPeer Reviewen
cg.subject.actionAreaResilient Agrifood Systems
cg.subject.ilriAMRen
cg.subject.ilriHUMAN HEALTHen
cg.subject.impactAreaNutrition, health and food security
cg.subject.sdgSDG 3 - Good health and well-beingen
cg.volume11en
dc.contributor.authorObanda, B.A.en
dc.contributor.authorGibbons, C.L.en
dc.contributor.authorFèvre, Eric M.en
dc.contributor.authorBebora, L.en
dc.contributor.authorGitao, G.en
dc.contributor.authorOgara, W.en
dc.contributor.authorWang, S.-H.en
dc.contributor.authorGebreyes, W.en
dc.contributor.authorNgetich, R.en
dc.contributor.authorBlane, B.en
dc.contributor.authorColl, F.en
dc.contributor.authorHarrison, E.M.en
dc.contributor.authorKariuki, S.en
dc.contributor.authorPeacock, S.J.en
dc.contributor.authorCook, Elizabeth A.J.en
dc.date.accessioned2022-12-02T09:00:16Zen
dc.date.available2022-12-02T09:00:16Zen
dc.identifier.urihttps://hdl.handle.net/10568/125757
dc.titleMulti-drug resistant Staphylococcus aureus carriage in abattoir workers in Busia, Kenyaen
dcterms.abstractAbattoir workers have been identified as high-risk for livestock-associated Staphylococcus aureus carriage. This study investigated S. aureus carriage in abattoir workers in Western Kenya. Nasal swabs were collected once from participants between February-November 2012. S. aureus was isolated using bacterial culture and antibiotic susceptibility testing performed using the VITEK 2 instrument and disc diffusion methods. Isolates underwent whole genome sequencing and Multi Locus Sequence Types were derived from these data. S. aureus (n = 126) was isolated from 118/737 (16.0%) participants. Carriage was higher in HIV-positive (24/89, 27.0%) than HIV–negative participants (94/648, 14.5%; p = 0.003). There were 23 sequence types (STs) identified, and half of the isolates were ST152 (34.1%) or ST8 (15.1%). Many isolates carried the Panton-Valentine leucocidin toxin gene (42.9%). Only three isolates were methicillin resistant S. aureus (MRSA) (3/126, 2.4%) and the prevalence of MRSA carriage was 0.4% (3/737). All MRSA were ST88. Isolates from HIV-positive participants (37.0%) were more frequently resistant to sulfamethoxazole/trimethoprim compared to isolates from HIV-negative participants (6.1%; p < 0.001). Similarly, trimethoprim resistance genes were more frequently detected in isolates from HIV-positive (81.5%) compared to HIV-negative participants (60.6%; p = 0.044). S. aureus in abattoir workers were representative of major sequence types in Africa, with a high proportion being toxigenic isolates. HIV-positive individuals were more frequently colonized by antimicrobial resistant S. aureus which may be explained by prophylactic antimicrobial use.en
dcterms.accessRightsOpen Access
dcterms.audienceAcademicsen
dcterms.audienceScientistsen
dcterms.available2022-12-01en
dcterms.bibliographicCitationObanda, B.A., Gibbons, C.L., Fèvre, E.M., Bebora, L., Gitao, G., Ogara, W., Wang, S.-H., Gebreyes, W., Ngetich, R., Blane, B., Coll, F., Harrison, E.M., Kariuki, S., Peacock, S.J. and Cook, E.A.J. 2022. Multi-drug resistant Staphylococcus aureus carriage in abattoir workers in Busia, Kenya. Antibiotics 11(12): 1726.en
dcterms.extent1726en
dcterms.issued2022-12-01en
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherMDPIen
dcterms.replaceshttps://hdl.handle.net/10568/171507en
dcterms.subjecthealthen
dcterms.subjectantimicrobial resistanceen
dcterms.subjectinfectious diseasesen
dcterms.subjectbiochemistryen
dcterms.subjectmicrobiologyen
dcterms.subjectabattoirsen
dcterms.subjectlabouren
dcterms.subjectantibioticsen
dcterms.subjecthuman immunodeficiency virusen
dcterms.subjectresistance to antibioticsen
dcterms.subjectstaphylococcus aureusen
dcterms.typeJournal Article

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