Multi-drug resistant Staphylococcus aureus carriage in abattoir workers in Busia, Kenya

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationUniversity of Nairobien_US
cg.contributor.affiliationOhio State Universityen_US
cg.contributor.affiliationKenya Medical Research Instituteen_US
cg.contributor.affiliationPublic Health Scotlanden_US
cg.contributor.affiliationUniversity of Liverpoolen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationUniversity of Cambridgeen_US
cg.contributor.crpAgriculture for Nutrition and Healthen_US
cg.contributor.donorNational Institutes of Health, United Statesen_US
cg.contributor.donorCGIAR Trust Funden_US
cg.contributor.donorMedical Research Council, United Kingdomen_US
cg.contributor.donorWellcome Trusten_US
cg.contributor.donorDepartment of Health, United Kingdomen_US
cg.contributor.initiativeOne Healthen_US
cg.coverage.countryKenyaen_US
cg.coverage.iso3166-alpha2KEen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986en_US
cg.creator.identifierElizabeth Cook: 0000-0001-6081-8363en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.3390/antibiotics11121726en_US
cg.isijournalISI Journalen_US
cg.issn2079-6382en_US
cg.issue12en_US
cg.journalAntibioticsen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.actionAreaResilient Agrifood Systemsen_US
cg.subject.ilriAMRen_US
cg.subject.ilriHUMAN HEALTHen_US
cg.subject.impactAreaNutrition, health and food securityen_US
cg.subject.sdgSDG 3 - Good health and well-beingen_US
cg.volume11en_US
dc.contributor.authorObanda, B.A.en_US
dc.contributor.authorGibbons, C.L.en_US
dc.contributor.authorFèvre, Eric M.en_US
dc.contributor.authorBebora, L.en_US
dc.contributor.authorGitao, G.en_US
dc.contributor.authorOgara, W.en_US
dc.contributor.authorWang, S.-H.en_US
dc.contributor.authorGebreyes, W.en_US
dc.contributor.authorNgetich, R.en_US
dc.contributor.authorBlane, B.en_US
dc.contributor.authorColl, F.en_US
dc.contributor.authorHarrison, E.M.en_US
dc.contributor.authorKariuki, S.en_US
dc.contributor.authorPeacock, S.J.en_US
dc.contributor.authorCook, Elizabeth A.J.en_US
dc.date.accessioned2022-12-02T09:00:16Zen_US
dc.date.available2022-12-02T09:00:16Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/125757en_US
dc.titleMulti-drug resistant Staphylococcus aureus carriage in abattoir workers in Busia, Kenyaen_US
dcterms.abstractAbattoir workers have been identified as high-risk for livestock-associated Staphylococcus aureus carriage. This study investigated S. aureus carriage in abattoir workers in Western Kenya. Nasal swabs were collected once from participants between February-November 2012. S. aureus was isolated using bacterial culture and antibiotic susceptibility testing performed using the VITEK 2 instrument and disc diffusion methods. Isolates underwent whole genome sequencing and Multi Locus Sequence Types were derived from these data. S. aureus (n = 126) was isolated from 118/737 (16.0%) participants. Carriage was higher in HIV-positive (24/89, 27.0%) than HIV–negative participants (94/648, 14.5%; p = 0.003). There were 23 sequence types (STs) identified, and half of the isolates were ST152 (34.1%) or ST8 (15.1%). Many isolates carried the Panton-Valentine leucocidin toxin gene (42.9%). Only three isolates were methicillin resistant S. aureus (MRSA) (3/126, 2.4%) and the prevalence of MRSA carriage was 0.4% (3/737). All MRSA were ST88. Isolates from HIV-positive participants (37.0%) were more frequently resistant to sulfamethoxazole/trimethoprim compared to isolates from HIV-negative participants (6.1%; p < 0.001). Similarly, trimethoprim resistance genes were more frequently detected in isolates from HIV-positive (81.5%) compared to HIV-negative participants (60.6%; p = 0.044). S. aureus in abattoir workers were representative of major sequence types in Africa, with a high proportion being toxigenic isolates. HIV-positive individuals were more frequently colonized by antimicrobial resistant S. aureus which may be explained by prophylactic antimicrobial use.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceAcademicsen_US
dcterms.audienceScientistsen_US
dcterms.available2022-12-01en_US
dcterms.bibliographicCitationObanda, B.A., Gibbons, C.L., Fèvre, E.M., Bebora, L., Gitao, G., Ogara, W., Wang, S.-H., Gebreyes, W., Ngetich, R., Blane, B., Coll, F., Harrison, E.M., Kariuki, S., Peacock, S.J. and Cook, E.A.J. 2022. Multi-drug resistant Staphylococcus aureus carriage in abattoir workers in Busia, Kenya. Antibiotics 11(12): 1726.en_US
dcterms.extent1726en_US
dcterms.issued2022-12-01en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherMDPIen_US
dcterms.subjecthealthen_US
dcterms.subjectantimicrobial resistanceen_US
dcterms.subjectinfectious diseasesen_US
dcterms.subjectbiochemistryen_US
dcterms.subjectmicrobiologyen_US
dcterms.typeJournal Articleen_US

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