How farm practices and antibiotic use drive disease incidence in smallholder livestock farms: Evidence from a survey in Uganda

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cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationLondon School of Hygiene and Tropical Medicineen
cg.contributor.affiliationInstitute of Virology and Immunology, Switzerlanden
cg.contributor.affiliationUniversity of Bernen
cg.contributor.affiliationSwedish University of Agricultural Sciencesen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.crpLivestock
cg.contributor.donorMedical Research Council, United Kingdomen
cg.contributor.donorSwedish International Development Cooperation Agencyen
cg.contributor.donorCGIAR Trust Funden
cg.contributor.initiativeSustainable Animal Productivity
cg.coverage.countryUganda
cg.coverage.iso3166-alpha2UG
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierMichel Dione: 0000-0001-7812-5776
cg.creator.identifierBarbara Wieland: 0000-0003-4020-9186
cg.creator.identifierUlf Magnusson: 0000-0002-7087-6820
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1016/j.onehlt.2023.100627en
cg.isijournalISI Journalen
cg.issn2352-7714en
cg.journalOne Healthen
cg.reviewStatusPeer Reviewen
cg.subject.actionAreaResilient Agrifood Systems
cg.subject.ilriAMRen
cg.subject.ilriANIMAL PRODUCTIONen
cg.subject.ilriLIVESTOCKen
cg.subject.impactAreaPoverty reduction, livelihoods and jobs
cg.subject.sdgSDG 3 - Good health and well-beingen
cg.volume17en
dc.contributor.authorEmes, E.en
dc.contributor.authorWieland, Barbaraen
dc.contributor.authorMagnusson, Ulfen
dc.contributor.authorDione, Michel M.en
dc.date.accessioned2023-09-18T08:03:55Zen
dc.date.available2023-09-18T08:03:55Zen
dc.identifier.urihttps://hdl.handle.net/10568/131883
dc.titleHow farm practices and antibiotic use drive disease incidence in smallholder livestock farms: Evidence from a survey in Ugandaen
dcterms.abstractBackground Antimicrobial resistance (AMR) is a growing threat to human and animal health, and the growth in AMR prevalence globally is thought to be partially driven by non-therapeutic antibiotic use in livestock production. However, livestock farms may depend on antibiotics as a prophylactic disease management tool, and reducing antibiotic use in isolation may harm farmers' economic security. In order to help farmers safely reduce their antibiotic use, we must first determine how necessary non-therapeutic antibiotic use is for disease management, and how other farm practices can guard against disease and make antibiotic use reduction safe and feasible. Methods Using the Antimicrobial Use in Livestock Production Settings (AMUSE) tool, a standardised survey tool for investigating attitudes and practices relating to antibiotic use on farms, we investigated the farming practices and animal disease outcomes of smallholder livestock farms in Uganda. We used logistic regression to investigate the effect of prophylactic antibiotic use; as well as of prophylactic vaccination, non-antimicrobial medicines, and on-farm biosecurity measures; on the likelihood of disease outbreaks. Findings We found that prophylactic antibiotic use did indeed seem to guard against disease outbreaks, underlining the rationality of non-therapeutic antibiotic use in smallholder livestock farms and the need to pair antibiotic use reduction with other interventions in order to mitigate risk. The most effective intervention pairing varied by species, with expanded access to animal health services and the use of prophylactic vaccination demonstrating the greatest potential overall. Implications These findings echo earlier results generated using the AMUSE survey tool. They should be followed by participatory research in which farmers are consulted to explore intervention options, and subsequently by farm-level intervention trials of combined antimicrobial stewardship interventions to verify their effectiveness.en
dcterms.accessRightsOpen Access
dcterms.audienceAcademicsen
dcterms.audienceScientistsen
dcterms.available2023-09-14
dcterms.bibliographicCitationEmes, E., Wieland, B., Magnusson, U. and Dione, M. 2023. How farm practices and antibiotic use drive disease incidence in smallholder livestock farms: Evidence from a survey in Uganda. One Health 17: 100627.en
dcterms.extent100627en
dcterms.issued2023-12
dcterms.languageen
dcterms.licenseCC-BY-NC-ND-4.0
dcterms.publisherElsevieren
dcterms.subjectantimicrobial resistanceen
dcterms.subjectanimal productionen
dcterms.subjectlivestocken
dcterms.typeJournal Article

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