How farm practices and antibiotic use drive disease incidence in smallholder livestock farms: Evidence from a survey in Uganda

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cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationLondon School of Hygiene and Tropical Medicineen_US
cg.contributor.affiliationInstitute of Virology and Immunology, Switzerlanden_US
cg.contributor.affiliationUniversity of Bernen_US
cg.contributor.affiliationSwedish University of Agricultural Sciencesen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.crpLivestocken_US
cg.contributor.donorMedical Research Council, United Kingdomen_US
cg.contributor.donorSwedish International Development Cooperation Agencyen_US
cg.contributor.donorCGIAR Trust Funden_US
cg.contributor.initiativeSustainable Animal Productivityen_US
cg.coverage.countryUgandaen_US
cg.coverage.iso3166-alpha2UGen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierMichel Dione: 0000-0001-7812-5776en_US
cg.creator.identifierBarbara Wieland: 0000-0003-4020-9186en_US
cg.creator.identifierUlf Magnusson: 0000-0002-7087-6820en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1016/j.onehlt.2023.100627en_US
cg.isijournalISI Journalen_US
cg.issn2352-7714en_US
cg.journalOne Healthen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.actionAreaResilient Agrifood Systemsen_US
cg.subject.ilriAMRen_US
cg.subject.ilriANIMAL PRODUCTIONen_US
cg.subject.ilriLIVESTOCKen_US
cg.subject.impactAreaPoverty reduction, livelihoods and jobsen_US
cg.subject.sdgSDG 3 - Good health and well-beingen_US
cg.volume17en_US
dc.contributor.authorEmes, E.en_US
dc.contributor.authorWieland, Barbaraen_US
dc.contributor.authorMagnusson, Ulfen_US
dc.contributor.authorDione, Michel M.en_US
dc.date.accessioned2023-09-18T08:03:55Zen_US
dc.date.available2023-09-18T08:03:55Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/131883en_US
dc.titleHow farm practices and antibiotic use drive disease incidence in smallholder livestock farms: Evidence from a survey in Ugandaen_US
dcterms.abstractBackground Antimicrobial resistance (AMR) is a growing threat to human and animal health, and the growth in AMR prevalence globally is thought to be partially driven by non-therapeutic antibiotic use in livestock production. However, livestock farms may depend on antibiotics as a prophylactic disease management tool, and reducing antibiotic use in isolation may harm farmers' economic security. In order to help farmers safely reduce their antibiotic use, we must first determine how necessary non-therapeutic antibiotic use is for disease management, and how other farm practices can guard against disease and make antibiotic use reduction safe and feasible. Methods Using the Antimicrobial Use in Livestock Production Settings (AMUSE) tool, a standardised survey tool for investigating attitudes and practices relating to antibiotic use on farms, we investigated the farming practices and animal disease outcomes of smallholder livestock farms in Uganda. We used logistic regression to investigate the effect of prophylactic antibiotic use; as well as of prophylactic vaccination, non-antimicrobial medicines, and on-farm biosecurity measures; on the likelihood of disease outbreaks. Findings We found that prophylactic antibiotic use did indeed seem to guard against disease outbreaks, underlining the rationality of non-therapeutic antibiotic use in smallholder livestock farms and the need to pair antibiotic use reduction with other interventions in order to mitigate risk. The most effective intervention pairing varied by species, with expanded access to animal health services and the use of prophylactic vaccination demonstrating the greatest potential overall. Implications These findings echo earlier results generated using the AMUSE survey tool. They should be followed by participatory research in which farmers are consulted to explore intervention options, and subsequently by farm-level intervention trials of combined antimicrobial stewardship interventions to verify their effectiveness.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceAcademicsen_US
dcterms.audienceScientistsen_US
dcterms.available2023-09-14en_US
dcterms.bibliographicCitationEmes, E., Wieland, B., Magnusson, U. and Dione, M. 2023. How farm practices and antibiotic use drive disease incidence in smallholder livestock farms: Evidence from a survey in Uganda. One Health 17: 100627.en_US
dcterms.extent100627en_US
dcterms.issued2023-12en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-NC-ND-4.0en_US
dcterms.publisherElsevieren_US
dcterms.subjectantimicrobial resistanceen_US
dcterms.subjectanimal productionen_US
dcterms.subjectlivestocken_US
dcterms.typeJournal Articleen_US

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