Identification and distribution of pathogens coinfecting with Brucella spp., Coxiella burnetii and Rift Valley fever virus in humans, livestock and wildlife

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationLos Alamos National Laboratoryen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationUniversity of Embuen_US
cg.contributor.donorUnited States Defense Threat Reduction Agencyen_US
cg.contributor.donorCGIAR Trust Funden_US
cg.contributor.initiativeOne Healthen_US
cg.creator.identifierBernard Bett: 0000-0001-9376-2941en_US
cg.creator.identifierDaniel Nthiwa: 0000-0002-3993-4164en_US
cg.creator.identifierSamuel O. Oyola: 0000-0002-6425-7345en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.1111/zph.12905en_US
cg.isijournalISI Journalen_US
cg.issn1863-1959en_US
cg.issue3en_US
cg.journalZoonoses and Public Healthen_US
cg.reviewStatusPeer Reviewen_US
cg.subject.actionAreaResilient Agrifood Systemsen_US
cg.subject.ilriBRUCELLOSISen_US
cg.subject.ilriLIVESTOCKen_US
cg.subject.ilriRVFen_US
cg.subject.ilriWILDLIFEen_US
cg.subject.ilriZOONOTIC DISEASESen_US
cg.subject.impactAreaNutrition, health and food securityen_US
cg.subject.sdgSDG 3 - Good health and well-beingen_US
cg.volume69en_US
dc.contributor.authorMiddlebrook, E.A.en_US
dc.contributor.authorRomero, A.T.en_US
dc.contributor.authorBett, Bernard K.en_US
dc.contributor.authorNthiwa, Danielen_US
dc.contributor.authorOyola, Samuel O.en_US
dc.contributor.authorFair, J.M.en_US
dc.contributor.authorBartlow, A.W.en_US
dc.date.accessioned2022-01-17T14:52:33Zen_US
dc.date.available2022-01-17T14:52:33Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/117536en_US
dc.titleIdentification and distribution of pathogens coinfecting with Brucella spp., Coxiella burnetii and Rift Valley fever virus in humans, livestock and wildlifeen_US
dcterms.abstractZoonotic diseases, such as brucellosis, Q fever and Rift Valley fever (RVF) caused by Brucella spp., Coxiella burnetii and RVF virus, respectively, can have devastating effects on human, livestock, and wildlife health and cause economic hardship due to morbidity and mortality in livestock. Coinfection with multiple pathogens can lead to more severe disease outcomes and altered transmission dynamics. These three pathogens can alter host immune responses likely leading to increased morbidity, mortality and pathogen transmission during coinfection. Developing countries, such as those commonly afflicted by outbreaks of brucellosis, Q fever and RVF, have high disease burden and thus common coinfections. A literature survey provided information on case reports and studies investigating coinfections involving the three focal diseases. Fifty five studies were collected demonstrating coinfections of Brucella spp., C. burnetii or RVFV with 50 different pathogens, of which 64% were zoonotic. While the literature search criteria involved 'coinfection', only 24/55 studies showed coinfections with direct pathogen detection methods (microbiology, PCR and antigen test), while the rest only reported detection of antibodies against multiple pathogens, which only indicate a history of co-exposure, not concurrent infection. These studies lack the ability to test whether coinfection leads to changes in morbidity, mortality or transmission dynamics. We describe considerations and methods for identifying ongoing coinfections to address this critical blind spot in disease risk management.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceAcademicsen_US
dcterms.audienceScientistsen_US
dcterms.available2022-01-15en_US
dcterms.bibliographicCitationMiddlebrook, E.A., Romero, A.T., Bett, B., Nthiwa, D., Oyola, S.O., Fair, J.M. and Bartlow, A.W. 2022. Identification and distribution of pathogens coinfecting with Brucella spp., Coxiella burnetii and Rift Valley fever virus in humans, livestock and wildlife. Zoonoses and Public Health 69(3): 175–194.en_US
dcterms.extent175-194en_US
dcterms.issued2022-05en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-NC-4.0en_US
dcterms.publisherWileyen_US
dcterms.subjectzoonosesen_US
dcterms.subjectlivestocken_US
dcterms.subjectwildlifeen_US
dcterms.subjectbrucellosisen_US
dcterms.subjectrift valley feveren_US
dcterms.subjectq feveren_US
dcterms.typeJournal Articleen_US

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