Identification and distribution of pathogens coinfecting with Brucella spp., Coxiella burnetii and Rift Valley fever virus in humans, livestock and wildlife

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationLos Alamos National Laboratoryen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationUniversity of Embuen
cg.contributor.donorUnited States Defense Threat Reduction Agencyen
cg.contributor.donorCGIAR Trust Funden
cg.contributor.initiativeOne Health
cg.creator.identifierBernard Bett: 0000-0001-9376-2941
cg.creator.identifierDaniel Nthiwa: 0000-0002-3993-4164
cg.creator.identifierSamuel O. Oyola: 0000-0002-6425-7345
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1111/zph.12905en
cg.isijournalISI Journalen
cg.issn1863-1959en
cg.issue3en
cg.journalZoonoses and Public Healthen
cg.reviewStatusPeer Reviewen
cg.subject.actionAreaResilient Agrifood Systems
cg.subject.ilriBRUCELLOSISen
cg.subject.ilriLIVESTOCKen
cg.subject.ilriRVFen
cg.subject.ilriWILDLIFEen
cg.subject.ilriZOONOTIC DISEASESen
cg.subject.impactAreaNutrition, health and food security
cg.subject.sdgSDG 3 - Good health and well-beingen
cg.volume69en
dc.contributor.authorMiddlebrook, E.A.en
dc.contributor.authorRomero, A.T.en
dc.contributor.authorBett, Bernard K.en
dc.contributor.authorNthiwa, Danielen
dc.contributor.authorOyola, Samuel O.en
dc.contributor.authorFair, J.M.en
dc.contributor.authorBartlow, A.W.en
dc.date.accessioned2022-01-17T14:52:33Zen
dc.date.available2022-01-17T14:52:33Zen
dc.identifier.urihttps://hdl.handle.net/10568/117536
dc.titleIdentification and distribution of pathogens coinfecting with Brucella spp., Coxiella burnetii and Rift Valley fever virus in humans, livestock and wildlifeen
dcterms.abstractZoonotic diseases, such as brucellosis, Q fever and Rift Valley fever (RVF) caused by Brucella spp., Coxiella burnetii and RVF virus, respectively, can have devastating effects on human, livestock, and wildlife health and cause economic hardship due to morbidity and mortality in livestock. Coinfection with multiple pathogens can lead to more severe disease outcomes and altered transmission dynamics. These three pathogens can alter host immune responses likely leading to increased morbidity, mortality and pathogen transmission during coinfection. Developing countries, such as those commonly afflicted by outbreaks of brucellosis, Q fever and RVF, have high disease burden and thus common coinfections. A literature survey provided information on case reports and studies investigating coinfections involving the three focal diseases. Fifty five studies were collected demonstrating coinfections of Brucella spp., C. burnetii or RVFV with 50 different pathogens, of which 64% were zoonotic. While the literature search criteria involved 'coinfection', only 24/55 studies showed coinfections with direct pathogen detection methods (microbiology, PCR and antigen test), while the rest only reported detection of antibodies against multiple pathogens, which only indicate a history of co-exposure, not concurrent infection. These studies lack the ability to test whether coinfection leads to changes in morbidity, mortality or transmission dynamics. We describe considerations and methods for identifying ongoing coinfections to address this critical blind spot in disease risk management.en
dcterms.accessRightsOpen Access
dcterms.audienceAcademicsen
dcterms.audienceScientistsen
dcterms.available2022-01-15
dcterms.bibliographicCitationMiddlebrook, E.A., Romero, A.T., Bett, B., Nthiwa, D., Oyola, S.O., Fair, J.M. and Bartlow, A.W. 2022. Identification and distribution of pathogens coinfecting with Brucella spp., Coxiella burnetii and Rift Valley fever virus in humans, livestock and wildlife. Zoonoses and Public Health 69(3): 175–194.en
dcterms.extent175-194en
dcterms.issued2022-05
dcterms.languageen
dcterms.licenseCC-BY-NC-4.0
dcterms.publisherWileyen
dcterms.subjectzoonosesen
dcterms.subjectlivestocken
dcterms.subjectwildlifeen
dcterms.subjectbrucellosisen
dcterms.subjectrift valley feveren
dcterms.subjectq feveren
dcterms.typeJournal Article

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CGIAR Initiative on One Health
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