Antibiotic ecotoxicity and resistance risks in resource-constrained chicken and pig farming environments

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationNanjing Agricultural Universityen
cg.contributor.affiliationUniversity of Liverpoolen
cg.contributor.affiliationUniversity of Copenhagenen
cg.contributor.donorFederal Ministry for Economic Cooperation and Development, Germanyen
cg.contributor.donorCGIAR Trust Funden
cg.contributor.donorNational Natural Science Foundation of Chinaen
cg.contributor.initiativeOne Health
cg.coverage.countryKenya
cg.coverage.iso3166-alpha2KE
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierGUDDA FREDRICK: 0000-0002-7645-7766en
cg.creator.identifierDishon Muloi: 0000-0002-6236-2280en
cg.creator.identifierFredrick Nganga: 0000-0002-0849-6018en
cg.creator.identifierArshnee Moodley: 0000-0002-6469-3948en
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.1038/s44259-024-00071-2en
cg.issn2731-8745en
cg.journalnpj Antimicrobials and Resistanceen
cg.reviewStatusPeer Reviewen
cg.subject.actionAreaResilient Agrifood Systems
cg.subject.ilriAMRen
cg.subject.ilriPIGSen
cg.subject.ilriPOULTRYen
cg.subject.impactAreaNutrition, health and food security
cg.subject.impactPlatformNutrition, Health and Food Security
cg.subject.sdgSDG 3 - Good health and well-beingen
cg.volume2en
dc.contributor.authorGudda, Fredricken
dc.contributor.authorMuloi, Dishonen
dc.contributor.authorNganga, Fredricken
dc.contributor.authorNolari, Cynthiaen
dc.contributor.authorGao, Y.en
dc.contributor.authorMoodley, Arshneeen
dc.date.accessioned2025-01-02T06:50:25Zen
dc.date.available2025-01-02T06:50:25Zen
dc.identifier.urihttps://hdl.handle.net/10568/168461
dc.titleAntibiotic ecotoxicity and resistance risks in resource-constrained chicken and pig farming environmentsen
dcterms.abstractAntimicrobial resistance (AMR) data from agroecosystems in low- and middle-income countries is limited. We surveyed chicken (n = 52) and pig (n = 47) farms in Kenya to understand AMR in animal-environment pathways. Using LC-MS/MS, we validated the methods for analyzing eight common antibiotics and quantified the associated risks. Chicken compost (25.8%, n = 97/376) had the highest antibiotics prevalence, followed by pig manure-fertilized soils (23.1%, n = 83/360). The average antibiotic concentration was 63.4 µg/kg, which is below the environmentally relevant threshold (100 µg/kg), except for trimethoprim (221.4 µg/kg) among antibiotics and pig manure-fertilized soils (129.3 µg/kg) across sample types. Similarly, the average AMR risk quotient (RQ) was low (RQ < 0.1), except for trimethoprim and sulfamethoxazole (RQ ≥ 1). Ecotoxicity and AMR risks increased with flock size and the number of antibiotics used by pigs. Continuous environmental monitoring and large-scale studies on antibiotic contamination are crucial for evidence-based pollution control and the effective mitigation of environmental AMR.en
dcterms.accessRightsOpen Access
dcterms.audienceAcademicsen
dcterms.audienceScientistsen
dcterms.available2024-12-30en
dcterms.bibliographicCitationGudda, F., Muloi, D., Nganga, F., Nolari, C., Gao, Y. and Moodley, A. 2024. Antibiotic ecotoxicity and resistance risks in resource-constrained chicken and pig farming environments. npj Antimicrobials and Resistance 2: 51.en
dcterms.extent51en
dcterms.issued2024-12-30en
dcterms.languageen
dcterms.licenseCC-BY-NC-ND-4.0
dcterms.publisherNature Researchen
dcterms.subjectantimicrobial resistanceen
dcterms.subjectpoultryen
dcterms.subjectswineen
dcterms.typeJournal Article

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