Characteristics of Staphylococcus aureus isolated from patients in Busia County Referral Hospital, Kenya

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cg.authorship.typesCGIAR and developing country instituteen_US
cg.authorship.typesCGIAR and advanced research instituteen_US
cg.contributor.affiliationUniversity of Nairobien_US
cg.contributor.affiliationOhio State Universityen_US
cg.contributor.affiliationKenya Medical Research Instituteen_US
cg.contributor.affiliationInternational Livestock Research Instituteen_US
cg.contributor.affiliationUniversity of Liverpoolen_US
cg.contributor.affiliationCentre for Infectious and Parasitic Diseases Control Research, Kenyaen_US
cg.contributor.affiliationUniversity of Cambridgeen_US
cg.contributor.affiliationLondon School of Hygiene and Tropical Medicineen_US
cg.contributor.affiliationWellcome Sanger Instituteen_US
cg.contributor.crpAgriculture for Nutrition and Healthen_US
cg.contributor.donorCGIAR Trust Funden_US
cg.contributor.donorNational Institutes of Health, United Statesen_US
cg.contributor.donorWellcome Trusten_US
cg.contributor.donorDepartment of Health, United Kingdomen_US
cg.contributor.initiativeOne Healthen_US
cg.coverage.countryKenyaen_US
cg.coverage.iso3166-alpha2KEen_US
cg.coverage.regionAfricaen_US
cg.coverage.regionEastern Africaen_US
cg.creator.identifierElizabeth Cook: 0000-0001-6081-8363en_US
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986en_US
cg.howPublishedFormally Publisheden_US
cg.identifier.doihttps://doi.org/10.3390/pathogens11121504en_US
cg.isijournalISI Journalen_US
cg.issn2076-0817en_US
cg.issue12en_US
cg.journalPathogensen_US
cg.reviewStatusPeer Reviewen_US
cg.speciesStaphylococcus aureusen_US
cg.subject.actionAreaResilient Agrifood Systemsen_US
cg.subject.ilriAMRen_US
cg.subject.ilriHUMAN HEALTHen_US
cg.subject.sdgSDG 3 - Good health and well-beingen_US
cg.volume11en_US
dc.contributor.authorObanda, B.A.en_US
dc.contributor.authorCook, Elizabeth A.J.en_US
dc.contributor.authorFèvre, Eric M.en_US
dc.contributor.authorBebora, L.en_US
dc.contributor.authorOgara, W.en_US
dc.contributor.authorWang, S.-H.en_US
dc.contributor.authorGebreyes, W.en_US
dc.contributor.authorNgetich, R.en_US
dc.contributor.authorWandede, D.en_US
dc.contributor.authorMuyodi, J.en_US
dc.contributor.authorBlane, B.en_US
dc.contributor.authorColl, F.en_US
dc.contributor.authorHarrison, E.M.en_US
dc.contributor.authorPeacock, S.J.en_US
dc.contributor.authorGitao, G.C.en_US
dc.date.accessioned2022-12-14T10:16:15Zen_US
dc.date.available2022-12-14T10:16:15Zen_US
dc.identifier.urihttps://hdl.handle.net/10568/125963en_US
dc.titleCharacteristics of Staphylococcus aureus isolated from patients in Busia County Referral Hospital, Kenyaen_US
dcterms.abstractStaphylococcus aureus is an important pathogen associated with hospital, community, and livestock-acquired infections, with the ability to develop resistance to antibiotics. Nasal carriage by hospital inpatients is a risk for opportunistic infections. Antibiotic susceptibility patterns, virulence genes and genetic population structure of S. aureus nasal isolates, from inpatients at Busia County Referral Hospital (BCRH) were analyzed. A total of 263 inpatients were randomly sampled, from May to July 2015. The majority of inpatients (85.9%) were treated empirically with antimicrobials, including ceftriaxone (65.8%) and metronidazole (49.8%). Thirty S. aureus isolates were cultured from 29 inpatients with a prevalence of 11% (10.3% methicillin-susceptible S. aureus (MSSA), 0.8% methicillin resistant S. aureus (MRSA)). Phenotypic and genotypic resistance was highest to penicillin-G (96.8%), trimethoprim (73.3%), and tetracycline (13.3%) with 20% of isolates classified as multidrug resistant. Virulence genes, Panton-Valentine leukocidin (pvl), toxic shock syndrome toxin-1 (tsst-1), and sasX gene were detected in 16.7%, 23.3% and 3.3% of isolates. Phylogenetic analysis showed 4 predominant clonal complexes CC152, CC8, CC80, and CC508. This study has identified that inpatients of BCRH were carriers of S. aureus harbouring virulence genes and resistance to a range of antibiotics. This may indicate a public health risk to other patients and the community.en_US
dcterms.accessRightsOpen Accessen_US
dcterms.audienceAcademicsen_US
dcterms.audienceScientistsen_US
dcterms.available2022-12-09en_US
dcterms.bibliographicCitationObanda, B.A., Cook, E.A.J., Fèvre, E.M., Bebora, L., Ogara, W., Wang, S.-H., Gebreyes, W., Ngetich, R., Wandede, D., Muyodi, J., Blane, B., Coll, F., Harrison, E.M., Peacock, S.J. and Gitao, G.C. 2022. Characteristics of Staphylococcus aureus isolated from patients in Busia County Referral Hospital, Kenya. Pathogens 11(12): 1504.en_US
dcterms.extent1504en_US
dcterms.issued2022-12-09en_US
dcterms.languageenen_US
dcterms.licenseCC-BY-4.0en_US
dcterms.publisherMDPIen_US
dcterms.subjecthealthen_US
dcterms.subjectantimicrobial resistanceen_US
dcterms.typeJournal Articleen_US

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