Characteristics of Staphylococcus aureus isolated from patients in Busia County Referral Hospital, Kenya

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cg.authorship.typesCGIAR and developing country instituteen
cg.authorship.typesCGIAR and advanced research instituteen
cg.contributor.affiliationUniversity of Nairobien
cg.contributor.affiliationOhio State Universityen
cg.contributor.affiliationKenya Medical Research Instituteen
cg.contributor.affiliationInternational Livestock Research Instituteen
cg.contributor.affiliationUniversity of Liverpoolen
cg.contributor.affiliationCentre for Infectious and Parasitic Diseases Control Research, Kenyaen
cg.contributor.affiliationUniversity of Cambridgeen
cg.contributor.affiliationLondon School of Hygiene and Tropical Medicineen
cg.contributor.affiliationWellcome Sanger Instituteen
cg.contributor.crpAgriculture for Nutrition and Health
cg.contributor.donorCGIAR Trust Funden
cg.contributor.donorNational Institutes of Health, United Statesen
cg.contributor.donorWellcome Trusten
cg.contributor.donorDepartment of Health, United Kingdomen
cg.contributor.initiativeOne Health
cg.coverage.countryKenya
cg.coverage.iso3166-alpha2KE
cg.coverage.regionAfrica
cg.coverage.regionEastern Africa
cg.creator.identifierElizabeth Cook: 0000-0001-6081-8363en
cg.creator.identifierEric M. Fèvre: 0000-0001-8931-4986en
cg.howPublishedFormally Publisheden
cg.identifier.doihttps://doi.org/10.3390/pathogens11121504en
cg.isijournalISI Journalen
cg.issn2076-0817en
cg.issue12en
cg.journalPathogensen
cg.reviewStatusPeer Reviewen
cg.speciesStaphylococcus aureusen
cg.subject.actionAreaResilient Agrifood Systems
cg.subject.ilriAMRen
cg.subject.ilriHUMAN HEALTHen
cg.subject.sdgSDG 3 - Good health and well-beingen
cg.volume11en
dc.contributor.authorObanda, B.A.en
dc.contributor.authorCook, Elizabeth A.J.en
dc.contributor.authorFèvre, Eric M.en
dc.contributor.authorBebora, L.en
dc.contributor.authorOgara, W.en
dc.contributor.authorWang, S.-H.en
dc.contributor.authorGebreyes, W.en
dc.contributor.authorNgetich, R.en
dc.contributor.authorWandede, D.en
dc.contributor.authorMuyodi, J.en
dc.contributor.authorBlane, B.en
dc.contributor.authorColl, F.en
dc.contributor.authorHarrison, E.M.en
dc.contributor.authorPeacock, S.J.en
dc.contributor.authorGitao, G.C.en
dc.date.accessioned2022-12-14T10:16:15Zen
dc.date.available2022-12-14T10:16:15Zen
dc.identifier.urihttps://hdl.handle.net/10568/125963
dc.titleCharacteristics of Staphylococcus aureus isolated from patients in Busia County Referral Hospital, Kenyaen
dcterms.abstractStaphylococcus aureus is an important pathogen associated with hospital, community, and livestock-acquired infections, with the ability to develop resistance to antibiotics. Nasal carriage by hospital inpatients is a risk for opportunistic infections. Antibiotic susceptibility patterns, virulence genes and genetic population structure of S. aureus nasal isolates, from inpatients at Busia County Referral Hospital (BCRH) were analyzed. A total of 263 inpatients were randomly sampled, from May to July 2015. The majority of inpatients (85.9%) were treated empirically with antimicrobials, including ceftriaxone (65.8%) and metronidazole (49.8%). Thirty S. aureus isolates were cultured from 29 inpatients with a prevalence of 11% (10.3% methicillin-susceptible S. aureus (MSSA), 0.8% methicillin resistant S. aureus (MRSA)). Phenotypic and genotypic resistance was highest to penicillin-G (96.8%), trimethoprim (73.3%), and tetracycline (13.3%) with 20% of isolates classified as multidrug resistant. Virulence genes, Panton-Valentine leukocidin (pvl), toxic shock syndrome toxin-1 (tsst-1), and sasX gene were detected in 16.7%, 23.3% and 3.3% of isolates. Phylogenetic analysis showed 4 predominant clonal complexes CC152, CC8, CC80, and CC508. This study has identified that inpatients of BCRH were carriers of S. aureus harbouring virulence genes and resistance to a range of antibiotics. This may indicate a public health risk to other patients and the community.en
dcterms.accessRightsOpen Access
dcterms.audienceAcademicsen
dcterms.audienceScientistsen
dcterms.available2022-12-09en
dcterms.bibliographicCitationObanda, B.A., Cook, E.A.J., Fèvre, E.M., Bebora, L., Ogara, W., Wang, S.-H., Gebreyes, W., Ngetich, R., Wandede, D., Muyodi, J., Blane, B., Coll, F., Harrison, E.M., Peacock, S.J. and Gitao, G.C. 2022. Characteristics of Staphylococcus aureus isolated from patients in Busia County Referral Hospital, Kenya. Pathogens 11(12): 1504.en
dcterms.extent1504en
dcterms.issued2022-12-09en
dcterms.languageen
dcterms.licenseCC-BY-4.0
dcterms.publisherMDPIen
dcterms.replaceshttps://hdl.handle.net/10568/171505en
dcterms.subjecthealthen
dcterms.subjectantimicrobial resistanceen
dcterms.subjectpathogensen
dcterms.subjecthospitalsen
dcterms.subjectantibioticsen
dcterms.subjectinfectionen
dcterms.subjectdrug resistanceen
dcterms.subjectpublic healthen
dcterms.subjectstaphylococcus aureusen
dcterms.typeJournal Article

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