Multiple pathogens co-exposure and associated risk factors among cattle reared in a wildlife-livestock interface area in Kenya
| cg.authorship.types | CGIAR and developing country institute | en_US |
| cg.contributor.affiliation | University of Embu | en_US |
| cg.contributor.affiliation | International Livestock Research Institute | en_US |
| cg.contributor.affiliation | Kenya Agricultural and Livestock Research Organization | en_US |
| cg.contributor.affiliation | Zoonotic Disease Unit, Kenya | en_US |
| cg.contributor.affiliation | Ministry of Health, Kenya | en_US |
| cg.contributor.affiliation | Ministry of Agriculture, Livestock, and Fisheries, Kenya | en_US |
| cg.contributor.donor | European Union | en_US |
| cg.contributor.donor | German Academic Exchange Service | en_US |
| cg.contributor.donor | United States Defense Threat Reduction Agency | en_US |
| cg.coverage.country | Kenya | en_US |
| cg.coverage.iso3166-alpha2 | KE | en_US |
| cg.coverage.region | Africa | en_US |
| cg.coverage.region | Eastern Africa | en_US |
| cg.creator.identifier | Daniel Nthiwa: 0000-0002-3993-4164 | en_US |
| cg.creator.identifier | Richard Nyamota: 0000-0002-9569-1953 | en_US |
| cg.creator.identifier | James Akoko: 0000-0001-5730-4505 | en_US |
| cg.creator.identifier | Bernard Bett: 0000-0001-9376-2941 | en_US |
| cg.howPublished | Formally Published | en_US |
| cg.identifier.doi | https://doi.org/10.3389/fvets.2024.1415423 | en_US |
| cg.isijournal | ISI Journal | en_US |
| cg.issn | 2297-1769 | en_US |
| cg.journal | Frontiers in Veterinary Science | en_US |
| cg.reviewStatus | Peer Review | en_US |
| cg.subject.actionArea | Resilient Agrifood Systems | en_US |
| cg.subject.ilri | ANIMAL DISEASES | en_US |
| cg.subject.ilri | BRUCELLOSIS | en_US |
| cg.subject.ilri | CATTLE | en_US |
| cg.subject.ilri | LIVESTOCK | en_US |
| cg.subject.ilri | WILDLIFE | en_US |
| cg.subject.impactArea | Nutrition, health and food security | en_US |
| cg.subject.impactPlatform | Nutrition, Health and Food Security | en_US |
| cg.subject.sdg | SDG 2 - Zero hunger | en_US |
| cg.volume | 11 | en_US |
| dc.contributor.author | Manyenya, S. | en_US |
| dc.contributor.author | Nthiwa, Daniel | en_US |
| dc.contributor.author | Lutta, H.O. | en_US |
| dc.contributor.author | Muturi, M. | en_US |
| dc.contributor.author | Nyamota, Richard | en_US |
| dc.contributor.author | Mwatondo, A. | en_US |
| dc.contributor.author | Watene, Grace | en_US |
| dc.contributor.author | Akoko, James M. | en_US |
| dc.contributor.author | Bett, Bernard K. | en_US |
| dc.date.accessioned | 2024-07-25T11:58:16Z | en_US |
| dc.date.available | 2024-07-25T11:58:16Z | en_US |
| dc.identifier.uri | https://hdl.handle.net/10568/149259 | en_US |
| dc.title | Multiple pathogens co-exposure and associated risk factors among cattle reared in a wildlife-livestock interface area in Kenya | en_US |
| dcterms.abstract | Introduction: Understanding multi-pathogen infections/exposures in livestock is critical to inform prevention and control measures against infectious diseases. We investigated the co-exposure of foot-and-mouth disease virus (FMDV), <i>Brucella</i> spp., <i>Leptospira</i> spp., and <i>Coxiella burnetii</i> in cattle in three zones stratified by land use change and with different wildlife-livestock interactions in Narok county, Kenya. We also assessed potential risk factors associated with the transmission of these pathogens in cattle. Methods: We identified five villages purposively, two each for areas with intensive (zone 1) and moderate wildlife-livestock interactions (zone 2) and one for locations with low wildlife-livestock interactions (zone 3). We sampled 1,170 cattle from 390 herds through a cross-sectional study and tested the serum samples for antibodies against the focal pathogens using enzyme-linked immunosorbent assay (ELISA) kits. A questionnaire was administered to gather epidemiological data on the putative risk factors associated with cattle’s exposure to the investigated pathogens. Data were analyzed using the Bayesian hierarchical models with herd number as a random effect to adjust for the within-herd clustering of the various co-exposures among cattle. Results: Overall, 88.0% (95% CI: 85.0–90.5) of the cattle tested positive for at least one of the targeted pathogens, while 41.7% (95% CI: 37.7–45.8) were seropositive to at least two pathogens. FMDV and <i>Brucella</i> spp. had the highest co-exposure at 33.7% (95% CI: 30.9–36.5), followed by FMDV and <i>Leptospira</i> spp. (21.8%, 95% CI: 19.5–24.4), <i>Leptospira</i> spp. and <i>Brucella</i> spp. (8.8%, 95% CI: 7.2–10.6), FMDV and <i>C. burnetii</i> (1.5%, 95% CI: 0.7–2.8), <i>Brucella</i> spp. and <i>C. burnetii</i> (1.0%, 95% CI: 0.3–2.2), and lowest for <i>Leptospira</i> spp. and <i>C. burnetii</i> (0.3%, 95% CI: 0.0–1.2). Cattle with FMDV and <i>Brucella</i> spp., and <i>Brucella</i> spp. and <i>Leptospira</i> spp. co-exposures and those simultaneously exposed to FMDV, <i>Brucella</i> spp. and <i>Leptospira</i> spp. were significantly higher in zone 1 than in zones 2 and 3. However, FMDV and <i>Leptospira</i> spp. co-exposure was higher in zones 1 and 2 than zone 3. Discussion/conclusion: We recommend the establishment of a One Health surveillance system in the study area to reduce the morbidity of the targeted zoonotic pathogens in cattle and the risks of transmission to humans. | en_US |
| dcterms.accessRights | Open Access | en_US |
| dcterms.audience | Academics | en_US |
| dcterms.audience | Scientists | en_US |
| dcterms.available | 2024-07-25 | en_US |
| dcterms.bibliographicCitation | Manyenya, S., Nthiwa, D., Lutta, H.O., Muturi, M., Nyamota, R., Mwatondo, A., Watene, G., Akoko, J. and Bett, B. 2024. Multiple pathogens co-exposure and associated risk factors among cattle reared in a wildlife-livestock interface area in Kenya. Frontiers in Veterinary Science 11: 1415423. | en_US |
| dcterms.extent | 1415423 | en_US |
| dcterms.issued | 2024-07-25 | en_US |
| dcterms.language | en | en_US |
| dcterms.license | CC-BY-4.0 | en_US |
| dcterms.publisher | Frontiers Media | en_US |
| dcterms.subject | cattle | en_US |
| dcterms.subject | livestock | en_US |
| dcterms.subject | wildlife | en_US |
| dcterms.subject | animal diseases | en_US |
| dcterms.subject | leptospirosis | en_US |
| dcterms.subject | foot-and-mouth disease | en_US |
| dcterms.subject | brucellosis | en_US |
| dcterms.subject | q fever | en_US |
| dcterms.type | Journal Article | en_US |
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ILRI articles in journals
Co-infection with Rift Valley fever virus, Brucella spp. and Coxiella burnetii in humans and animals in Kenya: Disease burden and ecological factors
ILRI animal and human health program outputs (2017-2024)
Linking biodiversity, ecosystem functions and services in the Serengeti-Mara region, East Africa: Drivers of change, causalities and sustainable management strategies (AfricanBioServices)
Co-infection with Rift Valley fever virus, Brucella spp. and Coxiella burnetii in humans and animals in Kenya: Disease burden and ecological factors
ILRI animal and human health program outputs (2017-2024)
Linking biodiversity, ecosystem functions and services in the Serengeti-Mara region, East Africa: Drivers of change, causalities and sustainable management strategies (AfricanBioServices)